Results 11 to 20 of about 1,047,595 (303)

Development of a Dynamic Physiologically Based Mechanistic Kidney Model to Predict Renal Clearance

CPT: Pharmacometrics & Systems Pharmacology, 2018
Renal clearance is usually predicted via empirical approaches including quantitative structure activity relationship and allometric scaling. Recently, mechanistic prediction approaches using in silico kidney models have been proposed.
Weize Huang, Nina Isoherranen
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Renal nitrate clearance in chronic kidney disease [PDF]

, 2020
Background Nitric oxide (NO) is rapidly oxidised in humans to nitrite and nitrate, with nitrate being present in much greater abundance. These oxidation products can be recycled back into nitric oxide via a complex entero-salivary pathway, thus ...
MJ Smallwood (21829553), N Benjamin (21825605), M Gilchrist (16723017), PG Winyard (21825524), AC Shore (16295798), JK Williams (14511497), RJ D'Souza (21913247)   +6 more
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Residual Renal Phosphate Clearance in Patients Receiving Hemodialysis or Hemodiafiltration

, 2023
Objectives: Substantial levels of residual renal clearance and urine output may occur in patients treated with hemodialysis or hemodiafiltration. However, the relationships among residual renal urea, creatinine, and phosphate clearances, respectively ...
Gaspar, Mariano, Gaspar, Mariano,, Jarava, Carlos, Daugirdas, John T., Bernat, Amparo,, Caparros, Sonia, Daugirdas, John T.,, Hegbrant, Jörgen,, Pizarro, Jose Luis,, Jarava, Carlos,, Bernat, Amparo, Del Castillo, Domingo, Pizarro, Jose Luis, Hegbrant, Jörgen, Strippoli, Giovanni F.M.,, Lund University., Caparros, Sonia,, Del Castillo, Domingo,, Strippoli, Giovanni F.M.   +18 more
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Creatinine clearance versus serum creatinine as a risk factor in cardiac surgery [PDF]

, 2003
Walter JA, Mortasawi A, Arnrich B, et al. Creatinine clearance versus serum creatinine as a risk factor in cardiac surgery. BMC Surgery. 2003;3(1): 4.BACKGROUND: Renal impairment is one of the predictors of mortality in cardiac surgery.
Mortasawi, Amir, Inez Frerichs, Albert, Alexander, Mortasawi Amir, Rosendahl Ulrich, Frerichs, Inez, Alexander Albert, Ulrich Rosendahl, Jürgen Ennker, Amir Mortasawi, Walter, Jörg, Arnrich, Bert, Rosendahl, Ulrich, Frerichs Inez, Albert Alexander, Arnrich Bert, Ennker Jürgen, Jörg Walter, Bert Arnrich, Walter, Jörg A., Walter Jörg, Ennker, Jürgen   +21 more
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The contribution of apixaban renal clearance to total clearance [PDF]

Journal of Thrombosis and Thrombolysis, 2015
To the Editor, Kreutz [1] reported that the renal clearance of absorbed active apixaban was 50 %. From the references cited, it is assumed that this value was obtained using the reported absolute oral bioavailability of 50 % [2] and data from a human absorption, distribution, metabolism, excretion (ADME) study, in which ~23 % of the radiolabeled ...
Frost, Charles, Boyd, Rebecca A.
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The Insulin Receptor Mediates Insulin’s Early Plasma Clearance by Liver, Muscle, and Kidney

Biomedicines, 2021
The role of the insulin receptor in mediating tissue-specific insulin clearance in vivo has not been reported. Using physiologic insulin doses, we measured the initial clearance rate (first 5 min) of intravenously injected ([125I]TyrA14)-insulin by ...
Rick I. Meijer, Eugene J. Barrett
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Renal Clearance of Fluoride.

Experimental Biology and Medicine, 1956
SummaryFluoride in dog plasma was completely ultrafilterable through visking membranes when tested using the centrifuge type apparatus. In dogs with a normal water load, the average normal renal fluoride clearance was 2.7 ml/min.; the fluoride : chloride clearance ratio, 19; and the fluoride : creatin-ine clearance ratio, 0.077.
P S, CHEN, D E, GARDNER, H C, HODGE, J A, O'BRIEN, F A, SMITH   +4 more
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Single-dose pharmacokinetics of recombinant human erythropoietin in patients with various degrees of renal failure [PDF]

, 1989
The pharmacokinetic profile of recombinant human erythropoietin (rHuEpo) was studied after a single intravenous dose of 150 U/kg in ten patients with various degrees of renal function: group I, creatinine clearance greater than 80 ml/min, n = 2; group II,
K. Jandeleit, Eckardt, K. U., A. Kurtz, B. Ehmer, A. Schreiber, Sieberth, H. G., Kindler, J., Jandeleit, K., Schreiber, A., Ehmer, B., Kurtz, Armin, Sieberth, H.-G., K.-U. Eckardt, Kurtz, A., H.-G. Sieberth, P. Scigalla, Scigalla, P., Eckardt, Kai-Uwe, J. Kindler   +18 more
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The Renal Clearable Magnetic Resonance Imaging Contrast Agents: State of the Art and Recent Advances

Molecules, 2020
The advancements of magnetic resonance imaging contrast agents (MRCAs) are continuously driven by the critical needs for early detection and diagnosis of diseases, especially for cancer, because MRCAs improve diagnostic accuracy significantly.
Xiaodong Li, Yanhong Sun, Lina Ma, Guifeng Liu, Zhenxin Wang   +4 more
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Renal Clearance of Erythromycin.

Experimental Biology and Medicine, 1955
SummaryThe renal clearance of erythromycin is slightly less than the glomerular filtration rate in dogs. Benemid appears to inhibit the reabsorption of erythromycin by the renal tubules.
C C, LEE, R C, ANDERSON, K K, CHEN
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