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Estimated glomerular filtration rate correlates poorly with four-hour creatinine clearance in critically ill patients with acute kidney injury. [PDF]
, 2013 Introduction. RIFLE and AKIN provide a standardised classification of acute kidney injury (AKI), but their categorical rather than continuous nature restricts their use to a research tool. A more accurate real-time description of renal function in AKI is
Iain A. M. MacPhee +5 more
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Prediction of human drug clearance and anticipation of clinical drug-drug interaction potential from in vitro drug transport studies [PDF]
, 2014 A major concern in drug development is the characterization of new molecular entities (NMEs) with respect to their safety and efficacy. Both factors are determined by the drug’s exposure within the body which itself is affected by drug clearance ...
Kunze, Annett
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ALTEX: Alternatives to Animal Experimentation, 2023 Accurate prediction of pharmacokinetic parameters, such as renal clearance, is fundamental to the development of effective and safe new treatments for patients. However, conventional renal models have a limited ability to predict renal drug secretion, a
Pedro Caetano-Pinto +5 more
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Ornipressin in the treatment of functional renal failure in decompensated liver cirrhosis [PDF]
, 1991 In 11 patients with decompensated cirrhosis and deteriorating renal function, the effect of the vasoconstrictor substance 8-ornithin vasopressin (ornipressin; POR 8; Sandoz, Basel, Switzerland) on renal function, hemodynamic parameters, and humoral ...
Reither, H. +8 more
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Journal of Intensive Care, 2019 Background The majority of patients with hemorrhagic stroke experience enhanced renal clearance or augmented renal clearance (ARC). The purpose of this study was to determine the impact of enhanced renal clearance or ARC on vancomycin pharmacokinetic (PK)
Kathryn A. Morbitzer +3 more
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Experimental Biology and Medicine, 1964 ConclusionThe renal clearance of oxacillin has been determined in normal males and found to be approximately 45% that of penicillin G. Implications regarding protein binding of oxacillin are discussed.
R J, VALENTINE, H J, SIMON, L A, RANTZ
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Renal Clearance of Ribonuclease
Experimental Biology and Medicine, 1958 Summary(1) The magnitude of the renal clearance of RNAase and its failure to change during loading suggests filtration of an unbound fraction of enzyme as the mode of excretion. (2) The arterial and renal vein concentrations of RNAase across the kidney were identical under the conditions of these experiments.
L B, BERMAN, J C, HOUCK
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Renal effects of the new calcium channel blocking drug isradipine [PDF]
, 1990 The acute effect of a single oral dose of isradipine 5 mg on blood pressure, renal haemodynamics, electrolyte excretion and plasma renin activity was studied in 10 healthy males.
Ress, K. M. +5 more
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APL Materials, 2017 Efficient renal clearance has been observed from ultrasmall zwitterionic glutathione-coated gold nanoparticles (GS-AuNPs), which have broad preclinical applications in cancer diagnosis and kidney ...
Xuhui Ning +6 more
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Contribution of Renal and Non‐Renal Clearance on Increased Total Clearance of Adalimumab in Glomerular Disease [PDF]
, 2013 The contribution of renal and non‐renal clearance toward targeted concentrations and/or effects of therapeutic proteins in nephrotic patients are unknown.
Debbie S. Gipson +9 more
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