Cetuximab Prevents Methotrexate-Induced Cytotoxicity in Vitro through Epidermal Growth Factor Dependent Regulation of Renal Drug Transporters. [PDF]
Mol Pharm, 2017 Caetano-Pinto P +13 more
europepmc +1 more source
Developing Micro/Nanostructured Fluidic Mixing Technology for Biomedical Applications
Advanced Science, EarlyView.This review critically evaluates how micro/nanostructured mixing technologies are redefining biomedical research. By synergizing fundamental analysis, numerical modeling, structural design, and external field manipulation, these systems attain unprecedented control over mass transport.
Junkai Wang +3 more
wiley +1 more source
Changes in Protein Expression of Renal Drug Transporters and Drug-Metabolizing Enzymes in Autosomal Dominant Polycystic Kidney Disease Patients. [PDF]
Clin Pharmacol TherTillmann AC +6 more
europepmc +1 more source
Uncertainty‐Guided Selective Adaptation Enables Cross‐Platform Predictive Fluorescence Microscopy
Advanced Intelligent Discovery, EarlyView.Deep learning models often fail when transferred to new microscopes. A novel framework overcomes this by selectively adapting the early layers governing low‐level image statistics, while freezing deep layers that encode morphology. This uncertainty‐guided approach enables robust, label‐free virtual staining across diverse systems, democratizing ...
Kai‐Wen K. Yang +9 more
wiley +1 more source
Interaction of the Atypical Tetracyclines Chelocardin and Amidochelocardin with Renal Drug Transporters. [PDF]
ACS Pharmacol Transl SciRox K +10 more
europepmc +1 more source
Renal Transport and Drug Interactions of Immunosuppressants. [PDF]
, 2008 Immunosuppressants are drugs that are used to treat inflammatory diseases, organ transplantation rejection, and cancer. These drugs are given to patients as single drugs, in combination, or together with other medications to treat accompanying diseases. Several severe side effects may result due to drug-drug interactions.
openaire
Natural History of Chronic Kidney Disease in Sickle Cell Disease
American Journal of Hematology, EarlyView.ABSTRACT Kidney complications, referred to as nephropathy, develop early in sickle cell disease (SCD). In addition to its known morbidity, abundant data show that chronic kidney disease (CKD) is associated with an increased mortality risk in SCD. Increasing evidence suggests that the natural history of SCD nephropathy is progressive. Initial glomerular
Kenneth I. Ataga
wiley +1 more source
Recent Trends in Metabolomics by NMR Spectroscopy
Angewandte Chemie, EarlyView.AI tools were applied to analyze more than 5 000 publications indexed in Scopus (2018–2025), identifying key trends and research directions in NMR‐based metabolomics. The artificial intelligence‐assisted workflow classified papers into six main fields of application, human health, food and nutrition, veterinary science, plants, environment, and ...
Giorgio Di Paco +6 more
wiley +2 more sources
American Journal of Medical Genetics Part A, EarlyView.ABSTRACT Multiple Acyl‐CoA Dehydrogenase Deficiency (MADD) is an autosomal recessive inborn error of metabolism caused by biallelic pathogenic variants in one of three known genes: ETFA, ETFB, and ETFDH. It can cause multisystem dysfunction, including cardiomyopathy in severe cases.
Yutaka Furuta +17 more
wiley +1 more source
Endothelin signaling in renal drug transport and toxicity. [PDF]
, 2005 RU Radboud Universiteit Nijmegen, 22 december ...
openaire