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Renal medullary fibrosis in hypertension
Human Pathology, 1971Abstract The degree of fibrosis in both the inner and outer medullae of the kidney was semiquantitated in 100 unselected autopsies in a blind study. A statistically significant relationship between renal medullary fibrosis in both zones, hypertension, and renal arterio- and arteriolar sclerosis was observed.
R C, Haggitt +2 more
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Cystic fibrosis and renal disease
Paediatric Respiratory Reviews, 2002Renal disease is relatively rare in cystic fibrosis even though the cystic fibrosis transmembrane regulator (CFTR) protein is expressed in abundance in the kidney. Aberrant CFTR expression probably explains the subtle abnormalities in renal concentrating and diluting ability described in cystic fibrosis and possibly the increased incidence of ...
S E, Stephens, S P A, Rigden
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Annual Review of Physiology, 2018
Tubulointerstitial fibrosis is a chronic and progressive process affecting kidneys during aging and in chronic kidney disease (CKD), regardless of cause. CKD and renal fibrosis affect half of adults above age 70 and 10% of the world's population. Although no targeted therapy yet exists to slow renal fibrosis, a number of important recent advances have
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Tubulointerstitial fibrosis is a chronic and progressive process affecting kidneys during aging and in chronic kidney disease (CKD), regardless of cause. CKD and renal fibrosis affect half of adults above age 70 and 10% of the world's population. Although no targeted therapy yet exists to slow renal fibrosis, a number of important recent advances have
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Renal Function in Cystic Fibrosis
Annals of the New York Academy of Sciences, 1986The effect of saline extracellular volume expansion (4 ml/min/10 kg b.w. X 60 min) on renal function has been studied in patients with cystic fibrosis (CF) and in normal age-matched controls. Basal values for glomerular filtration rate (GFR), renal plasma flow (RPF), tubular sodium and chloride (Na, Cl) handling were similar in both groups.
B M, Assael +7 more
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Renal Interstitial Lymphangiogenesis in Renal Fibrosis
2019The basic physiological functions of the lymphatic system include absorption of water and macromolecular substances in the interstitial fluid to maintain the fluid homeostasis, promoting the intestinal absorption of nutrients such as lipids and vitamins from food.
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Chronic Deteriorating Renal Function and Renal Fibrosis
2008Chronic deteriorating renal function and renal fibrosis are common features in progressive renal diseases. Renal fibrosis may determine the degree of impairment of renal function and predict long-term prognosis. Advances in cell biology have provided a new understanding of the molecular events underlying renal fibrosis. A central event in tissue repair
Yoshitaka, Isaka +2 more
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Renal fibrosis: Recent translational aspects
Matrix Biology, 2018Renal fibrogenesis is the common final pathway to all renal injuries that consequently leads to Chronic Kidney Disease (CKD). Renal fibrogenesis corresponds to the replacement of renal functional tissue by extra-cellular matrix proteins, mainly collagens, that ultimately impairs kidney function.
Hélène, François +1 more
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Novel insights into renal fibrosis
Current Opinion in Nephrology and Hypertension, 2003Renal fibrosis characterizes a common endpoint of diverse renal diseases which leads to functional impairment ultimately resulting in terminal renal failure.Recent advances in this field led to the discovery of several novel mediators as well as novel aspects of known mediators.
Frank, Eitner, Jürgen, Floege
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Renal Autotransplantation for Retroperitoneal Fibrosis
Journal of Urology, 1981Idiopathic retroperitoneal fibrosis is a disease of unknown etiology characterized by a dense rubbery retroperitoneal plaque that encases 1 or both ureters, causing hydronephrosis and impairing renal function. Primary or recurrent disease may result in extensive ureteral damage, leaving the urologist with limited surgical options.
J, Palleschi, J W, McAninch
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Hypoxia and Renal Tubulointerstitial Fibrosis
2019Hypoxia, one of the most common causes of kidney injury, is a key pathological condition in various kidney diseases. Renal fibrosis is the terminal pathway involved in the continuous progression of chronic kidney disease (CKD), characterized by glomerulosclerosis and tubulointerstitial fibrosis (TIF).
Zuo-Lin, Li, Bi-Cheng, Liu
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