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Urinary Biomarkers of Renal Fibrosis
2019Renal fibrosis is the common pathological pathway of progressive CKD. The commonly used biomarkers in clinical practice are not optimal to detect injury or predict prognosis. Therefore, it is crucial to develop novel biomarkers to allow prompt intervention. Urine serves as a valuable resource of biomarker discovery for kidney diseases.
Le-Ting, Zhou, Lin-Li, Lv, Bi-Cheng, Liu
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Molecular basis of renal fibrosis
Pediatric Nephrology, 2000All progressive renal diseases are the consequence of a process of destructive fibrosis. This review will focus on tubulointerstitial fibrosis, the pathophysiology of which will be divided into four arbitrary phases. First is the cellular activation and injury phase. The tubules are activated, the peritubular capillary endothelium facilitates migration
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Animal Models of Renal Fibrosis
2005Most of the present knowledge on pathomechanism of renal fibrosis is based on experimental studies with laboratory animals. Today, a variety of genetic and inducible animal models that mimic primary causes of human disease such as diabetes mellitus, glomerulonephritis, or lupus erythematodes are available.
Michael, Zeisberg +2 more
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Inflammatory Mediators and Renal Fibrosis
2019Renal inflammation is the initial, healthy response to renal injury. However, prolonged inflammation promotes the fibrosis process, which leads to chronic pathology and eventually end-stage kidney disease. There are two major sources of inflammatory cells: first, bone marrow-derived leukocytes that include neutrophils, macrophages, fibrocytes and mast ...
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Treatment of renal cell carcinoma: Current status and future directions
Ca-A Cancer Journal for Clinicians, 2017Pedro Coelho Barata, Brian I Rini
exaly