Results 81 to 90 of about 22,320,192 (343)

Postural Changes in Blood Pressure Associated with Interactions between Candidate Genes for Chronic Respiratory Diseases and Exposure to Particulate Matter [PDF]

, 2009
BACKGROUND. Fine particulate matter [aerodynamic diameter ≤ 2.5 μm (PM2.5)] has been associated with autonomic dysregulation. OBJECTIVE. We hypothesized that PM2.5 influences postural changes in systolic blood pressure (ΔSBP) and in diastolic blood ...
Andrea Baccarelli, Audrey Poon, Augusto A. Litonjua, Benjamini Y, David Sparrow, Elissa Wilker, Ferris BG, Helen Suh, Joel Schwartz, Murray A. Mittleman, Pantel Vokonas, Poon AH, Poon AH, Robert O. Wright   +13 more
core   +3 more sources

Adaptive Antioxidant Nanomedicines Inhibit Ferroptosis in Renal Tubular Epithelial Cells to Alleviate Diabetic Kidney Disease

Advanced Science, EarlyView.
In this study, an adaptive antioxidant nanodrug (AAN) is developed through the self‐polymerization of L‐selenocysteine. The AAN exhibits dual functionalities: antioxidant activity (scavenging reactive oxygen species) and mitochondrial targeting. Moreover, the released selenium (Se) participates in the synthesis of glutathione peroxidase 4 (GPX4), which
Zerun Liu, Ting Huang, Ying Hong, Yuqi Yang, Wensheng Chen, Qingtao Zeng, Qiaohui Chen, Yongqi Yang, Xiaohong Ying, Wan Zeng, Ziyu Wu, Tianjiao Zhao, Xuesi Wan, Jianlin Chen, Kelong Ai, Qiong Huang   +15 more
wiley   +1 more source

THE INFLUENCE OF TISSUE ANGIOTENSINS ON ELEMENTS OF THE CARDIOVASCULAR SYSTEM (LECTURE 2)

Байкальский медицинский журнал
Relevance. One of the main causes of death according to the World Health Organization is cardiovascular diseases. It is well known that dysregulation and/or overexpression of elements of the renin-angiotensin system leads to many negative vascular ...
Liudmila O Gutsol, Irina E Egorova
doaj   +1 more source

The Impact of the Renin-Angiotensin-Aldosterone System on Inflammation, Coagulation, and Atherothrombotic Complications, and to Aggravated COVID-19

Frontiers in Pharmacology, 2021
Atherosclerosis is considered a disease caused by a chronic inflammation, associated with endothelial dysfunction, and several mediators of inflammation are up-regulated in subjects with atherosclerotic disease.
M. Ekholm, T. Kahan
doaj   +1 more source

An Update on the Tissue Renin Angiotensin System and Its Role in Physiology and Pathology

Journal of Cardiovascular Development and Disease, 2019
In its classical view, the renin angiotensin system (RAS) was defined as an endocrine system involved in blood pressure regulation and body electrolyte balance.
A. Nehme, Fouad A. Zouein, Z. Zayeri, K. Zibara   +3 more
semanticscholar   +1 more source

Drugs and the renin-angiotensin system in covid-19

British medical journal, 2020
Clinical effects are unpredictable, so treatment decisions must be tailored and ...
J. Aronson, R. Ferner
semanticscholar   +1 more source

Inhibition of AMPKα Pathway by Podocyte GOLM1 Exacerbates Diabetic Nephrology in Mice

Advanced Science, EarlyView.
Podocyte Golgi membrane protein 1 interacts with epidermal growth factor receptor to inhibit peroxisome proliferator activated receptor γ, and then inactivates adenosine monophosphate activated protein kinase α pathway, which facilitates diabetes‐related inflammation, oxidative damage, apoptosis, and renal dysfunction.
Peng Xu, Kaiqiang Li, Huasong Liu, Aibo Xu, Zhewei Zhang, Yimin Yang, Xiaobo Lai, Ke Hao, Kui Fang, Zeyu Lai, Xiping Ou, Yuqun Cai, Zhen Wang, Keda Lu, Wanli Jiang   +14 more
wiley   +1 more source

Within the Brain: The Renin Angiotensin System

International Journal of Molecular Sciences, 2018
For many years, modulators of the renin angiotensin system (RAS) have been trusted by clinicians for the control of essential hypertension. It was recently demonstrated that these modulators have other pleiotropic properties independent of their ...
L. Jackson, Wael Eldahshan, S. Fagan, A. Ergul   +3 more
semanticscholar   +1 more source

Loss of Hepatic Angiotensinogen Attenuates Diastolic Dysfunction in Heart Failure with Preserved Ejection Fraction

Advanced Science, EarlyView.
Increased hepatic angiotensinogen (AGT) abundance leads to cardiac diastolic dysfunction via the AngII‐independent pathway. Liver‐derived AGT is internalized by LRP2 in cardiac endothelial cells, subsequently contributing to myocardial diastolic dysfunction by suppressing microvascular angiogenesis via inhibiting the GATA2/Pim3 pathway.
Zetao Heng, Min Hong, Zhaocai Zhang, Ximing Ye, Jianan Zhou, Wentao Wu, Jiabing Rong, Yinchuan Xu   +7 more
wiley   +1 more source

Impaired angiotensin II signaling in septic shock

Annals of Intensive Care
Recent years have seen a resurgence of interest for the renin–angiotensin–aldosterone system in critically ill patients. Emerging data suggest that this vital homeostatic system, which plays a crucial role in maintaining systemic and renal hemodynamics ...
Adrien Picod, Bruno Garcia, Dirk Van Lier, Peter Pickkers, Antoine Herpain, Alexandre Mebazaa, Feriel Azibani   +6 more
doaj   +1 more source