Results 121 to 130 of about 98,465 (163)
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Medical Clinics of North America, 1987
The renin-angiotensin systems are important regulators of cardiovascular homeostasis and participate in a variety of pathological conditions. Recent advances have not only clarified the functioning of the systemic renin cascade but have also indicated the importance of the generation of angiotensin in tissues.
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The renin-angiotensin systems are important regulators of cardiovascular homeostasis and participate in a variety of pathological conditions. Recent advances have not only clarified the functioning of the systemic renin cascade but have also indicated the importance of the generation of angiotensin in tissues.
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The renin-angiotensin system and atherosclerosis
Current Hypertension Reports, 2006Atherosclerosis is an insidious and complex disease of large- and medium-sized arteries. The primum movens of the disease is characterized by co-localization of lipids, inflammatory cells, and fibrous elements within the intima of vessels. Starting as a "fatty streak," the disease evolves over decades into complex lesions that can progress toward a ...
Mazzolai L, Hayoz D
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C. The renin-angiotensin system. A history and review of the renin-angiotensin system
Proceedings of the Royal Society of London. Series B. Biological Sciences, 1969Abstract An outline of the development of knowledge of the renin-angiotensin system is given, and the nature of the enzyme renin, its site within the kidney as well as in other organs, and its action on plasma substrate to form first the decapeptide which is converted to the biologically active octapeptide, are considered. The methods
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The dynamics of the renin-angiotensin system
Proceedings of the Royal Society of London. Series B. Biological Sciences, 1969Abstract We have used the blood-bathed organ technique (Vane 1964) to study the liberation of renin into the bloodstream and the subsequent formation of angiotensin I and angiotensin II. The rat isolated colon was superfused (Gaddum 1953) continuously with heparinized blood from dogs, to detect changes in angiotensin II concentration ...
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The CNS renin-angiotensin system
Cell and Tissue Research, 2006The renin-angiotensin system (RAS) is one of the best-studied enzyme-neuropeptide systems in the brain and can serve as a model for the action of peptides on neuronal function in general. It is now well established that the brain has its own intrinsic RAS with all its components present in the central nervous system.
O, von Bohlen und Halbach, D, Albrecht
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[The tissue renin-angiotensin systems].
Annali italiani di medicina interna : organo ufficiale della Societa italiana di medicina interna, 1993Over the past 10 years, our understanding of the renin-angiotensin system has changed greatly, reflecting significant advances in this field. Studies in cell biology, the application of molecular biological techniques, and studies of angiotensin kinetics have provided evidence for the existence in various sites (cardiac, cerebral, renal, vascular and ...
Neri Serneri GG +3 more
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Renin angiotensin system and ASCVD
Current Opinion in Cardiology, 2000The renin angiotensin system was first described over 100 years ago and is still the focus of intense clinical and basic science investigation. The renin angiotensin system was demonstrated to play a major pathogenetic role in hypertension. The development of inhibitors of angiotensin-converting enzyme and specific receptor blockers for angiotensin-II ...
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Renin-Angiotensin System in Sepsis
Clinical and Experimental Hypertension. Part A: Theory and Practice, 1987The time course of the components of the renin-angiotensin system was investigated in the plasma of three patients on the intensive care unit. Two of them, which were both polytraumatized, suffered from adult respiratory distress syndrome (ARDS). All patients had sepsis and impaired pulmonary and renal function.
U, Hilgenfeldt +4 more
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Reproduction and the renin-angiotensin system
Neuroscience & Biobehavioral Reviews, 1995A unique aspect of the circulating renin-angiotensin system and the many independent tissue renin-angiotensin systems is their interactions at multiple levels with reproduction. These interactions, which have received relatively little attention, include effects of estrogens and possibly androgens on hepatic and renal angiotensinogen mRNA; effects of ...
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The Pulmonary Renin-Angiotensin System
Current Pharmaceutical Design, 2003The circulating renin-angiotensin system (RAS) has a well-described role in circulatory homeostasis. Recently, local tissue-based RAS have also been described which appear to play a key role in the injury/repair response. The expression of RAS components and the elevation of angiotensin converting enzyme in a number of interstitial lung diseases ...
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