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The aspartyl-protease renin is the key regulator of the renin-angiotensin-aldosterone system, which is critically involved in salt, volume, and blood pressure homeostasis of the body. Renin is mainly produced and released into circulation by the so-called juxtaglomerular epithelioid cells, located in the walls of renal afferent arterioles at the ...
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Renin Tachyphylaxis and ‘Renin Hypertension’ in the Rabbit
American Journal of Physiology-Legacy Content, 1956A ‘renin hypertension’ was produced by means of a constant intravenous infusion of a carefully quantitated renin solution. Renin injections were then superimposed to the point of tachyphylaxis. In all cases when tachyphylaxis was established, the blood pressure gradually returned to preinfusion levels.
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