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Renin, Prorenin, and the (Pro)Renin Receptor [PDF]
, 2009 The discovery of a receptor for renin and for its inactive precursor prorenin, and the introduction of renin inhibitors in therapeutic, has renewed the interest for the physiology of the renin angiotensin system (RAS) and has brought prorenin back in the spotlight.
Aurélie Contrepas, Genevieve Nguyen
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Is Angiotensinogen a Renin Inhibitor and Not the Substrate for Renin?
Journal of Hypertension, 1986The cleavage of the angiotensinogen molecule by renin is slow. The rate constant for cleavage of the enzyme-substrate complex, Kcat (turnover number) is lower than usual for enzymes (0.6/s for the homologous human renin reactions and 0.15/s for the homologous mouse renin reaction).
Knud Poulsen, Jørgen Jacobsen
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Inactive Renin — A Renin Proenzyme?
1977Human plasma contains an inactive form of renin with a m.w. of 55,000, as against around 40,000 for active human renin. After acidification to pH 3.0 or incubation with trypsin, the inactive renin becomes more active and the molecular weight falls to that of active renin.
A. McConnell, B. J. Leckie, J. Jordan
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The Journal of Clinical Endocrinology & Metabolism, 1977
Renin activity, concentration, substrate and reactivity were determined in normal subjects as well as in hypertensive subjects with suppressed and normal plasma renin activity. Renin substrate measurements were similar in all groups. Renin reactivity, a measure of circulating modifiers of the renin reaction, was significantly increased in both ...
Edwin L. Cohen +2 more
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Renin activity, concentration, substrate and reactivity were determined in normal subjects as well as in hypertensive subjects with suppressed and normal plasma renin activity. Renin substrate measurements were similar in all groups. Renin reactivity, a measure of circulating modifiers of the renin reaction, was significantly increased in both ...
Edwin L. Cohen +2 more
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Biochemical Society Transactions, 1984
Biochemical features of renin have been studied. Determination of the amino acid sequence and catalytically essential groups in the active sites of mouse submandibular gland revealed the similarity of renin with acid proteases. Yet stringent substrate specificity, neutral pH optimum of its enzyme activity and the unique structure of the activation ...
Tadashi Inagami +3 more
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Biochemical features of renin have been studied. Determination of the amino acid sequence and catalytically essential groups in the active sites of mouse submandibular gland revealed the similarity of renin with acid proteases. Yet stringent substrate specificity, neutral pH optimum of its enzyme activity and the unique structure of the activation ...
Tadashi Inagami +3 more
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Ergebnisse der Physiologie Biologischen Chemie und Experimentellen Pharmakologie, 1959
The reviewer of this subject can approach his task in two ways; he can attempt to be exhaustive and include all the references to all the literature on the subject, or he can be selective and consider only that which has thrown new light in recent years. I propose to take the latter course.
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The reviewer of this subject can approach his task in two ways; he can attempt to be exhaustive and include all the references to all the literature on the subject, or he can be selective and consider only that which has thrown new light in recent years. I propose to take the latter course.
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Archives of Internal Medicine, 1973
Renin plays a significant role in normal and pathophysiologic states. Among the various factors affecting renin secretion are the afferent arteriole acting as a baroreceptor, the macula densa as a sensor of sodium delivery to the distal tubule, and the adrenergic nervous system.
Jay H. Stein, Thomas F. Ferris
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Renin plays a significant role in normal and pathophysiologic states. Among the various factors affecting renin secretion are the afferent arteriole acting as a baroreceptor, the macula densa as a sensor of sodium delivery to the distal tubule, and the adrenergic nervous system.
Jay H. Stein, Thomas F. Ferris
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Clinical and Experimental Pharmacology and Physiology, 1986
SUMMARY1. New gene data for three aspartyl proteases (human renin, mouse renin and human pepsin) permitted closer analysis of the gene duplication and fusion hypothesis for the evolution of this family of enzymes.2. Alignment of sequences in the hemilobes of human pepsin revealed only weak homology in amino acid sequences.
Brain J. Morris, Daniel F. Catanzaro
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SUMMARY1. New gene data for three aspartyl proteases (human renin, mouse renin and human pepsin) permitted closer analysis of the gene duplication and fusion hypothesis for the evolution of this family of enzymes.2. Alignment of sequences in the hemilobes of human pepsin revealed only weak homology in amino acid sequences.
Brain J. Morris, Daniel F. Catanzaro
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Renin, (pro)renin and receptor: an update
Clinical Science, 2010PRR [(pro)renin receptor] was named after its biological characteristics, namely the binding of renin and of its inactive precursor prorenin, that triggers intracellular signalling involving ERK (extracellular-signal-regulated kinase) 1/2. However the gene encoding for PRR is named ATP6ap2 (ATPase 6 accessory protein 2) because PRR was initially found ...
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Nephron, 1975
The factors involved in renin release have been extensively evaluated. The primary determinants are the transmural pressure at the afferent arteriole, sodium delivery to the macula densa, and the activity of the adrenergic nervous system. Other possible factors include circulating catecholamines, the serum and cerebrospinal fluid sodium concentration ...
Jay H. Stein +2 more
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The factors involved in renin release have been extensively evaluated. The primary determinants are the transmural pressure at the afferent arteriole, sodium delivery to the macula densa, and the activity of the adrenergic nervous system. Other possible factors include circulating catecholamines, the serum and cerebrospinal fluid sodium concentration ...
Jay H. Stein +2 more
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