Results 41 to 50 of about 614,145 (271)

Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids

Molecular Oncology, EarlyView.
This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici, Soheil Akbari, Ceyda Caliskan, Canan Celiker, Ozden Oz, Leman Binokay, Gökhan Karakulah, Serif Senturk, Esra Erdal   +8 more
wiley   +1 more source

Constraint Reorganization Consistent with the Dirac Procedure [PDF]

, 2001
The way of finding all the constraints in the Hamiltonian formulation of singular (in particular, gauge) theories is called the Dirac procedure. The constraints are naturally classified according to the correspondig stages of this procedure. On the other
Gitman, D. M., Tyutin, I. V.
core   +2 more sources

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source

Power Inside the Firm and the Market: A General Equilibrium Approach [PDF]

, 2006
Recent years have witnessed an enormous amount of reorganization of the corporate sector in the US and in Europe. This paper examines the role of market competition for this trend in corporate reorganization.
Marin, Dalia, Verdier, Thierry
core   +2 more sources

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source

THE DEVELOPMENT OF THE PLEKHANOV RUSSIAN ACADEMY OF ECONOMICS IN THE LATE 1980s – EARLY 2000s

Вестник Российского экономического университета имени Г. В. Плеханова, 2018
The article describes key problems, which the Russian Plekhanov Academy of Economics faced during the years of reforms and steps  taken by the Academy administration in the late 1980s – early 2000s in order to overcome them and reorganize the Academy ...
Irina M. Kornilova, Mikhail V. Sokolov
doaj   +1 more source

ATG4B is required for mTORC1‐mediated anabolic activity and is associated with clinical outcomes in non‐small cell lung cancer

FEBS Open Bio, EarlyView.
The relationship between anabolic and catabolic processes governing lung cancer cell growth is nuanced. We show that ATG4B, an autophagy regulator, is elevated in lung cancer and that high ATG4B is associated with worse patient outcomes. Targeting ATG4B in cells reduces growth, protein synthesis, and mTORC1 activity, demonstrating a new relationship ...
Patrick J. Ryan, Bethany C. Guerra, Selina Uranga, Jessica M. Cardin, Steven E. Riechman, Mariana Janini Gomes, James D. Fluckey   +6 more
wiley   +1 more source

LEGAL BASIS AND SPECIFIC FEATURES OF FEDERAL INSTITUTIONS OF PUBLIC HEALTH REORGANIZATION ACCORDING TO RUSSIAN CIVIL LEGISLATION

Вестник Российского экономического университета имени Г. В. Плеханова, 2018
The development of the Public Health system as a field of public health reproduction is a priority objective of any social state and the Russian Federation according to Article 7 of the Constitution is a social state.
Oleg E. Karpov, Irina V. Fadeeva, Dmitriy N. Nikitenko, Victor V. Tretyakov, Ekaterina M. Nushtaeva   +4 more
doaj   +1 more source

Motor Functional Reorganization Is Triggered by Tumor Infiltration Into the Primary Motor Area and Repeated Surgery

Frontiers in Human Neuroscience, 2020
In patients with gliomas, motor deficits are not always observed, even though tumor cells infiltrate into the motor area. Currently, it is recognized that this phenomenon can occur through the neuroplasticity potential.
Riho Nakajima, Masashi Kinoshita, Mitsutoshi Nakada   +2 more
doaj   +1 more source

A New Paradigm for the Integrated Sustainability and Management of the Tehran Metropolis: Capital City Reorganization or Relocation [PDF]

برنامه‌ریزی توسعه شهری و منطقه‌ای, 2018
It seems that we are not in harmony with the changes of the Tehran metropolis as the capital city of Iran. We often encounter what Cowell and Owens call an implementation deficit.
Mahmood Jomehpour
doaj   +1 more source