Results 51 to 60 of about 3,010,841 (282)

Skilled reaching deterioration contralateral to cervical hemicontusion in rats is reversed by pregabalin treatment conditional upon its early administration

PAIN Reports, 2019
. Introduction:. Gabapentinoids are first-line treatments for painful traumatic and nontraumatic central nervous system disorders. Evidence from a large human study suggests that early use of gabapentinoids after spinal cord injury improves motor scores.
Erin L.K.S. Erskine, Brittney D. Smaila, Ward Plunet, Jie Liu, Elizabeth E. Raffaele, Wolfram Tetzlaff, John L.K. Kramer, Matt S. Ramer   +7 more
doaj   +1 more source

The age, NT-proBNP, and Ejection Fraction Score as a Novel Predictor of Clinical Outcomes in CAD Patients After PCI

Clinical and Applied Thrombosis/Hemostasis, 2022
Background Previous evidences have been proved that age, N-terminal pro-B-type natriuretic peptide (NT-proBNP), and ejection fraction are tightly associated with the long-term outcomes in patients suffered from coronary artery disease (CAD).
Lei Fan MD, Zeng-Lei Zhang MD, Jun-Nan Tang PhD, Qian-Qian Guo MD, Jian-Chao Zhang MD, Meng-Die Cheng MD, Feng-Hua Song MD, Zhi-Yu Liu MD, Kai Wang MD, Li-Zhu Jiang MD, Xiao-Ting Yue MD, Yan Bai MD, Xin-Ya Dai MD, Ru-Jie Zheng MD, Ying-Ying Zheng PhD, Jin-Ying Zhang PhD   +15 more
doaj   +1 more source

A novel splice variant of the DNA-PKcs gene is associated with clinical and cellular radiosensivity in a patient with xeroderma pigmentosum [PDF]

, 2010
Background: Radiotherapy-induced DNA double-strand breaks (DSBs) are critical cytotoxic lesions. Inherited defects in DNA DSB repair pathways lead to hypersensitivity to ionising radiation, immunodeficiency and increased cancer incidence.
Abbaszadeh, Fatemah, Arlett, Colin F., Bourton, E.C, Clingen, Peter H., Green, M H, Makarov, E.M., Newbold, R.F, Parris, C.N., Plowman, P.N, Themis, M.   +9 more
core   +1 more source

PICALM::MLLT10 translocated leukemia

FEBS Letters, EarlyView.
This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen, Antonia C. Nakatsugawa, Natalie Barton, Henry Haines, Gary S. Stein, Janet L. Stein, Daniel S. Wechsler, Jessica L. Heath   +7 more
wiley   +1 more source

Community Repair Project: Strategic Social Skill Mobilization For Sustainable Fashion [PDF]

, 2011
As an effort towards sustainability, fashion needs to embrace repair as a designed feature for everyday clothes. Normally we think of repair as merely fixing a broken object, making it functional again. But repair can be so much more. It can be an update
Williams, Dilys
core  

MintHint: Automated Synthesis of Repair Hints

, 2013
Being able to automatically repair programs is an extremely challenging task. In this paper, we present MintHint, a novel technique for program repair that is a departure from most of today's approaches. Instead of trying to fully automate program repair,
Cadar C., Chandola V., Cramér H., Groce A., Jin G., Kendall M., Konighofer R., Vessey I.   +7 more
core   +1 more source

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

Characterization of the gut microbiome in a porcine model of thoracic spinal cord injury

BMC Genomics, 2021
Background The gut microbiome is a diverse network of bacteria which inhabit our digestive tract and is crucial for efficient cellular metabolism, nutrient absorption, and immune system development.
Adam Doelman, Seth Tigchelaar, Brian McConeghy, Sunita Sinha, Martin S. Keung, Neda Manouchehri, Megan Webster, Shera Fisk, Charlotte Morrison, Femke Streijger, Corey Nislow, Brian K. Kwon   +11 more
doaj   +1 more source

Generic Secure Repair for Distributed Storage [PDF]

, 2017
This paper studies the problem of repairing secret sharing schemes, i.e., schemes that encode a message into $n$ shares, assigned to $n$ nodes, so that any $n-r$ nodes can decode the message but any colluding $z$ nodes cannot infer any information about ...
Bruck, Jehoshua, Huang, Wentao
core   +2 more sources

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source