Results 61 to 70 of about 3,010,841 (282)
, 2016 This paper reports on EPSRC-funded research that explores the role of repair in creating new models of sustainable business. In the lifecycle stage of repair we explore what 'broken' means and uncover the nature of local and dispersed repair activities ...
Charter, M. +6 more
core +1 more source
FEBS Letters, EarlyView.In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai +9 more
wiley +1 more source
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
Locally Repairable Codes with Multiple Repair Alternatives
, 2013 Distributed storage systems need to store data redundantly in order to provide some fault-tolerance and guarantee system reliability. Different coding techniques have been proposed to provide the required redundancy more efficiently than traditional ...
Hollmann, Henk D. L. +2 more
core +1 more source
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
TET knockout cells transit between pluripotent states and exhibit precocious germline entry
The EMBO JournalTET1, TET2 and TET3 are DNA demethylases with important roles in development and differentiation. To assess the contributions of TET proteins to cell function during early development, single and compound knockouts of Tet genes in mouse pluripotent ...
Raphaël Pantier +7 more
doaj +1 more source
Pilot and Feasibility Studies, 2020 Background In early-stage breast cancer, the cornerstone of treatment is surgery. After breast-conserving surgery, adjuvant radiotherapy has shown to improve locoregional control and overall survival rates.
Hans Van Hulle +13 more
doaj +1 more source
, 2016 Repair has visibly come to the fore in recent academic and policy debates, to the point that 'repair studies' is now emerging as a novel focus of research. Through the lens of repair, scholars with diverse backgrounds are coming together to rethink our relationships with the human-made matters, tools and objects that are the material mesh in which ...
Graziano, Valeria, Trogal, Kim
openaire +1 more source
FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source
Storage codes -- coding rate and repair locality [PDF]
, 2013 The {\em repair locality} of a distributed storage code is the maximum number of nodes that ever needs to be contacted during the repair of a failed node.
Hollmann, Henk D. L.
core