Results 61 to 70 of about 3,009,431 (281)

Annexin-A5 assembled into two-dimensional arrays promotes cell membrane repair [PDF]

, 2011
Eukaryotic cells possess a universal repair machinery that ensures rapid resealing of plasma membrane disruptions. Before resealing, the torn membrane is submitted to considerable tension, which functions to expand the disruption.
A Brisson, A Brisson, AK McNeil, B Brachvogel, B Brachvogel, B Brachvogel, B Jeppesen, C Cai, C Cai, C Pigault, C Vénien-Bryan, CE Creutz, CJ Merrifield, D Bansal, D Bansal, D Voges, EB Babiychuk, F D'Acquisto, F Oling, F Oling, G Mosser, GQ Bi, HA Andree, I Reviakine, J Liu, JH Rand, K Balasubramanian, K Monastyrskaya, L Glover, M Menke, M Rodahl, MA Kaetzel, MA Swairjo, MP Sheetz, NJ Lennon, NO Concha, NO Concha, O Lambert, O Saurel, PL McNeil, PL McNeil, PL McNeil, Q Ling, R Bérat, R Huber, R Huber, R Langen, R Richter, RA Steinhardt, RP Richter, S Yasuda, SE Moss, T Skrahina, T Togo, T Yeung, V Gerke, Y Mo   +56 more
core   +2 more sources

Time after time – circadian clocks through the lens of oscillator theory

FEBS Letters, EarlyView.
Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo, Carolin Ector, Hanspeter Herzel   +2 more
wiley   +1 more source

Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions

FEBS Letters, EarlyView.
Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf, Nicholas F. Downing, Kaitlyn M. Mills, Samuel C. Metcalfe, Alexander E. Kritzer, Lindsey D. Mayo, Peter C. Hollenhorst   +6 more
wiley   +1 more source

MintHint: Automated Synthesis of Repair Hints

, 2013
Being able to automatically repair programs is an extremely challenging task. In this paper, we present MintHint, a novel technique for program repair that is a departure from most of today's approaches. Instead of trying to fully automate program repair,
Cadar C., Chandola V., Cramér H., Groce A., Jin G., Kendall M., Konighofer R., Vessey I.   +7 more
core   +1 more source

The newfound relationship between extrachromosomal DNAs and excised signal circles

FEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

TET knockout cells transit between pluripotent states and exhibit precocious germline entry

The EMBO Journal
TET1, TET2 and TET3 are DNA demethylases with important roles in development and differentiation. To assess the contributions of TET proteins to cell function during early development, single and compound knockouts of Tet genes in mouse pluripotent ...
Raphaël Pantier, Elisa Barbieri, Sara Gonzalez Brito, Ella Thomson, Tülin Tatar, Douglas Colby, Man Zhang, Ian Chambers   +7 more
doaj   +1 more source

Human stem cells transplanted into the rat stroke brain migrate to the spleen via lymphatic and inflammation pathways

Haematologica, 2019
Despite mounting evidence of a massive peripheral inflammatory response accompanying stroke, the ability of intracerebrally transplanted cells to migrate to the periphery and sequester systemic inflammation remains unexamined.
Kaya Xu, Jea-Young Lee, Yuji Kaneko, Julian P. Tuazon, Fernando Vale, Harry van Loveren, Cesario V. Borlongan   +6 more
doaj   +1 more source

Feasibility study on pre or postoperative accelerated radiotherapy (POP-ART) in breast cancer patients

Pilot and Feasibility Studies, 2020
Background In early-stage breast cancer, the cornerstone of treatment is surgery. After breast-conserving surgery, adjuvant radiotherapy has shown to improve locoregional control and overall survival rates.
Hans Van Hulle, Vincent Vakaet, Giselle Post, Annick Van Greveling, Chris Monten, An Hendrix, Koen Van de Vijver, Jo Van Dorpe, Pieter De Visschere, Geert Braems, Katrien Vandecasteele, Hannelore Denys, Wilfried De Neve, Liv Veldeman   +13 more
doaj   +1 more source

Repair Matters [PDF]

, 2016
Repair has visibly come to the fore in recent academic and policy debates, to the point that 'repair studies' is now emerging as a novel focus of research. Through the lens of repair, scholars with diverse backgrounds are coming together to rethink our relationships with the human-made matters, tools and objects that are the material mesh in which ...
Graziano, Valeria, Trogal, Kim
openaire   +1 more source

Conserved structural motifs in PAS, LOV, and CRY proteins regulate circadian rhythms and are therapeutic targets

FEBS Letters, EarlyView.
Cryptochrome and PAS/LOV proteins play intricate roles in circadian clocks where they act as both sensors and mediators of protein–protein interactions. Their ubiquitous presence in signaling networks has positioned them as targets for small‐molecule therapeutics. This review provides a structural introduction to these protein families.
Eric D. Brinckman, Anna E. Lester, Brian D. Zoltowski   +2 more
wiley   +1 more source