Results 71 to 80 of about 3,010,841 (282)

The Error and Repair Catastrophes: A Two-Dimensional Phase Diagram in the Quasispecies Model

, 2003
This paper develops a two gene, single fitness peak model for determining the equilibrium distribution of genotypes in a unicellular population which is capable of genetic damage repair.
A. Giraud, A. Sasaki, C.O. Wilke, C.O. Wilke, C.O. Wilke, C.O. Wilke, D. Alves, E. Tannenbaum, E. van Nimwegen, F. Taddei, I. Matic, J. LeClerc, J. Swetina, K. Negishi, M. Eigen, M. Eigen, M. Kolar, M. Nilsson, M. Nilsson, O. Tenaillon, P. Schuster, P. Tarazona, P.D. Sniegowski, P.D. Sniegowski, P.R.A. Campos, R. Pastor-Satorras, S. Altmeyer, S. Crotty, S. Franz, S. Galluccio   +29 more
core   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

Squamous Cell Carcinoma of the Bulbar Urethra Accompanied by Lichen Sclerosus: A Case Report

American Journal of Men's Health, 2018
Squamous cell carcinoma (SCC) of the bulbar urethra accompanied by lichen sclerosus (LS) is rarely reported. This study reports the case of a 56-year-old man with urethral squamous cell carcinoma (USCC) accompanied by a long history of genital LS.
Xufeng Peng, Hailin Guo, Chongrui Jin, Lin Wang, Yinglong Sa   +4 more
doaj   +1 more source

Warranty Cost Analysis with an Alternating Geometric Process

, 2018
In this study we model the warranty claims process and evaluate the warranty servicing costs under non-renewing and renewing free repair warranties. We assume that the repair time for rectifying the claims is non-zero and the repair cost is a function of
Arnold, Richard, Chukova, Stefanka, Hayakawa, Yu, Marshall, Sarah   +3 more
core  

Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway

Molecular Oncology, EarlyView.
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed, Kerstin Huebner, Katharina Erlenbach‐Wuensch, Chuanpit Hampel, Daniela Thalheim, Adriana Vial‐Roehe, Bodee Nutho, Susanne Merkel, Arndt Hartmann, Pithi Chanvorachote, Regine Schneider‐Stock   +10 more
wiley   +1 more source

Foundations for Teleoperation and Motion Planning Towards Robot-Assisted Aircraft Fuel Tank Inspection

Aerospace
The aviation industry relies on continuous inspections to ensure infrastructure safety, particularly in confined spaces like aircraft fuel tanks, where human inspections are labor-intensive, risky, and expose workers to hazardous exposures.
Adrián Ricárdez Ortigosa, Marc Bestmann, Florian Heilemann, Johannes Halbe, Lewe Christiansen, Rebecca Rodeck, Gerko Wende   +6 more
doaj   +1 more source

Human stem cells transplanted into the rat stroke brain migrate to the spleen via lymphatic and inflammation pathways

Haematologica, 2019
Despite mounting evidence of a massive peripheral inflammatory response accompanying stroke, the ability of intracerebrally transplanted cells to migrate to the periphery and sequester systemic inflammation remains unexamined.
Kaya Xu, Jea-Young Lee, Yuji Kaneko, Julian P. Tuazon, Fernando Vale, Harry van Loveren, Cesario V. Borlongan   +6 more
doaj   +1 more source

An Explicit Construction of Systematic MDS Codes with Small Sub-packetization for All-Node Repair

, 2018
An explicit construction of systematic MDS codes, called HashTag+ codes, with arbitrary sub-packetization level for all-node repair is proposed. It is shown that even for small sub-packetization levels, HashTag+ codes achieve the optimal MSR point for ...
Gligoroski, Danilo, Kralevska, Katina
core   +1 more source

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source

Cis‐regulatory and long noncoding RNA alterations in breast cancer – current insights, biomarker utility, and the critical need for functional validation

Molecular Oncology, EarlyView.
The noncoding region of the genome plays a key role in regulating gene expression, and mutations within these regions are capable of altering it. Researchers have identified multiple functional noncoding mutations associated with increased cancer risk in the genome of breast cancer patients.
Arnau Cuy Saqués, Aracele Martinez‐Mendez, John Crown, Alex Eustace   +3 more
wiley   +1 more source