Results 81 to 90 of about 3,009,431 (281)
β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1
Molecular Oncology, EarlyView.Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero +8 more
wiley +1 more source
Stem Cell Research in : Sources, Geopolitical Influence, and Transplantation
Cell Transplantation, 2010 If the rapidly progressing field of stem cell research reaches its full potential, successful treatments and enhanced understanding of many diseases are the likely results.
David J. Eve +3 more
doaj +1 more source
Effect of DNA repair deficiencies on the cytotoxicity of resveratrol [PDF]
, 2015 Numerous preclinical studies have shown that the naturally-occurring polyphenol resveratrol may produce health-beneficial effects in a variety of disorders, including cancer, diabetes, Alzheimer, and cardiovascular diseases.
Burgos Morón, Estefanía +5 more
core
Molecular Oncology, EarlyView.AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou +5 more
wiley +1 more source
Celiac Disease and Skin Diseases: A Bidirectional Mendelian Randomization Study
Clinical, Cosmetic and Investigational DermatologyChenyang Ge,1 Yizheng Wang,2 Xuegang Zhao,1 Jiawen Hao,1 Jing Zhang,1 Mengyuan Lu,1 Congying Li,1 Jianke Feng,1 Qingfu Zhang1 1Burn and Wound Repair Center, Hebei Medical University Third Hospital, Shijiazhuang, Hebei, 050000, People’s Republic of China;
Ge C +8 more
doaj
Molecular Oncology, EarlyView.PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham +21 more
wiley +1 more source
Stem cell therapy for neurological disorders: A focus on aging
Neurobiology of Disease, 2019 Age-related neurological disorders continue to pose a significant societal and economic burden. Aging is a complex phenomenon that affects many aspects of the human body.
Hung Nguyen +8 more
doaj +1 more source
Community Repair Project: Strategic Social Skill Mobilization For Sustainable Fashion [PDF]
, 2011 As an effort towards sustainability, fashion needs to embrace repair as a designed feature for everyday clothes. Normally we think of repair as merely fixing a broken object, making it functional again. But repair can be so much more. It can be an update
Williams, Dilys
core
Molecular Oncology, EarlyView.This study explores salivary RNA for breast cancer (BC) diagnosis, prognosis, and follow‐up. High‐throughput RNA sequencing identified distinct salivary RNA signatures, including novel transcripts, that differentiate BC from healthy controls, characterize histological and molecular subtypes, and indicate lymph node involvement.
Nicholas Rajan +9 more
wiley +1 more source
The Error and Repair Catastrophes: A Two-Dimensional Phase Diagram in the Quasispecies Model
, 2003 This paper develops a two gene, single fitness peak model for determining the equilibrium distribution of genotypes in a unicellular population which is capable of genetic damage repair.
A. Giraud +29 more
core +1 more source