Results 51 to 60 of about 861,022 (290)

Biomechanical Tolerance of Whole Lumbar Spines in Straightened Posture Subjected to Axial Acceleration [PDF]

, 2017
Quantification of biomechanical tolerance is necessary for injury prediction and protection of vehicular occupants. This study experimentally quantified lumbar spine axial tolerance during accelerative environments simulating a variety of military and ...
Baisden, Jamie L., Chirvi, Sajal, Curry, William H., Doan, Ninh, Maiman, Dennis J., Paskoff, Glenn, Pintar, Frank A., Shender, Barry S., Stemper, Brian D., Yoganandan, Narayan   +9 more
core   +2 more sources

Peptide‐based ligand antagonists block a Vibrio cholerae adhesin

FEBS Letters, EarlyView.
The structure of a peptide‐binding domain of the Vibrio cholerae adhesin FrhA was solved by X‐ray crystallography, revealing how the inhibitory peptide AGYTD binds tightly at its Ca2+‐coordinated pocket. Structure‐guided design incorporating D‐amino acids enhanced binding affinity, providing a foundation for developing anti‐adhesion therapeutics ...
Mingyu Wang, Grace Du, Charity Yongo‐Luwawa, Angelina Lu, Brett Kinrade, Kim Munro, Karl E. Klose, William D. Lubell, Peter Davies, Shuaiqi Guo   +9 more
wiley   +1 more source

A repeated strike loading organ culture model for studying compression-associated chronic disc degeneration

Biomolecules & Biomedicine
Mechanical stress has been viewed as one of the key risk factors in accelerating the intervertebral disc degeneration process. The goal of the present study was to employ a repeated strike loading bovine caudal disc system to elucidate the ...
Baoliang Li, Xu Chen, Hongkun Chen, Fu Zhang, Jianfeng Li, Zhengya Zhu, Tao Tang, Manman Gao, Nianhu Li, Liang Ma, Zhiyu Zhou   +10 more
doaj   +1 more source

Real‐time assay of ribonucleotide reductase activity with a fluorescent RNA aptamer

FEBS Letters, EarlyView.
Ribonucleotide reductases (RNR) synthesize DNA building blocks de novo, making them crucial in DNA replication and drug targeting. FLARE introduces the first single‐tube real‐time coupled RNR assay, which enables isothermal tracking of RNR activity at nanomolar enzyme levels and allows the reconstruction of allosteric regulatory patterns and rapid ...
Jacopo De Capitani, Noemi E. Nwosu, Viktoria Gocke, Müge Kasanmascheff, Hannes Mutschler   +4 more
wiley   +1 more source

A study of repeated impact loading on a symmetrical carbon fibre laminate [PDF]

, 2007
The behaviour of a symmetric laminate under repeated low energy hits of a 12.1mm hemispheric impactor was evaluated. The laminate was able to endure 20 collisions with the striker before perforation. The rate of damage progression was characterised by an
Banks, W.M., David-West, O.S., Nash, D.H.   +2 more
core  

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Substrate specificity of Burkholderia pseudomallei multidrug transporters is influenced by the hydrophilic patch in the substrate‐binding pocket

FEBS Letters, EarlyView.
Multidrug transporters BpeB and BpeF from the Gram‐negative pathogen Burkholderia pseudomallei have a hydrophilic patch in their substrate‐binding pocket. Drug susceptibility tests and growth curve analyses using an Escherichia coli recombinant expression system revealed that the hydrophilic patches of BpeB and BpeF are involved in the substrate ...
Ui Okada, Satoshi Murakami
wiley   +1 more source

A dissipated energy comparison to evaluate fatigue resistance using 2PB [PDF]

, 2012
Flexural fatigue due to repeated traffic loading is a process of cumulative damage and one of the main failure modes of flexible pavement structures. Typically, micro-cracks originate at the bottom of an asphalt concrete layer due to horizontal tensile ...
AIREY G, DI MINO, Gaetano, GRENFELL J, MAGGIORE C, MARSAC P   +4 more
core  

Strand plasticity governs fatigue in colloidal gels

, 2017
Repeated loading of a solid leads to microstructural damage that ultimately results in catastrophic material failure. While posing a major threat to the stability of virtually all materials, the microscopic origins of fatigue, especially for soft solids,
Sprakel, Joris, van der Gucht, Jasper, van Doorn, Jan Maarten, Verweij, Joanne E.   +3 more
core   +2 more sources

PrasugRel versus adjusted high-dose clopidogrel in patients with high on- clopidogrel platelet reactivity: the PECS-HPR randomized, multicenter study [PDF]

, 2015
background: Repeated loading doses (LD) of clopidogrel were shown to effectively overcome high on-clopidogrel platelet reactivity (HPR); however, comparison to potent P2Y12-inhibitors is lacking.
Aradi, Dániel
core   +1 more source