Results 1 to 10 of about 432,839 (343)

Ischemia/Reperfusion

Comprehensive Physiology, 2017
ABSTRACTIschemic disorders, such as myocardial infarction, stroke, and peripheral vascular disease, are the most common causes of debilitating disease and death in westernized cultures. The extent of tissue injury relates directly to the extent of blood flow reduction and to the length of the ischemic period, which influence the levels to which ...
Theodore, Kalogeris, Christopher P, Baines, Maike, Krenz, Ronald J, Korthuis   +3 more
openaire   +3 more sources

Ischemia/reperfusion-activated ferroptosis in the early stage triggers excessive inflammation to aggregate lung injury in rats

Frontiers in Medicine, 2023
ObjectiveLung ischemia/reperfusion injury (LIRI) is a clinical syndrome of acute lung injury that occurs after lung transplantation or remote organ ischemia.
Xiujie Liu, Xiujie Liu, Binhui Pan, Xiaoting Wang, Xiaoting Wang, Junpeng Xu, Junpeng Xu, Xinyu Wang, Xinyu Wang, Zhengyang Song, Zhengyang Song, Eryao Zhang, Fangyan Wang, Fangyan Wang, Wantie Wang, Wantie Wang   +15 more
doaj   +1 more source

Alox15/15-HpETE Aggravates Myocardial Ischemia-Reperfusion Injury by Promoting Cardiomyocyte Ferroptosis

Circulation, 2023
Background: Myocardial ischemia-reperfusion (I/R) injury causes cardiac dysfunction to myocardial cell loss and fibrosis. Prevention of cell death is important to protect cardiac function after I/R injury.
Wenbin Cai, Le Liu, Xuelian Shi, Yanan Liu, Jin Wang, Xuan Fang, Zhipeng Chen, Ding Ai, Yi Zhu, Xu Zhang   +9 more
semanticscholar   +1 more source

TRPM4 Participates in Aldosterone-Salt-Induced Electrical Atrial Remodeling in Mice

Cells, 2021
Aldosterone plays a major role in atrial structural and electrical remodeling, in particular through Ca2+-transient perturbations and shortening of the action potential.
Christophe Simard, Virginie Ferchaud, Laurent Sallé, Paul Milliez, Alain Manrique, Joachim Alexandre, Romain Guinamard   +6 more
doaj   +1 more source

Kinetic and mechanistic diversity of intestinal immune homeostasis characterized by rapid removal of gut bacteria

Gut Microbes, 2023
Symbiotic microbiota critically contribute to host immune homeostasis in effector cell-specific manner. For exclusion of microbial component, germ-free animals have been the gold standard method.
Da-Jung Jung, Ledia Gebremedhin, Byoungsook Goh, Ji-Sun Yoo, Francesca Gazzaniga, Dennis L. Kasper, Sungwhan F. Oh   +6 more
doaj   +1 more source

Early activation and recruitment of invariant natural killer T cells during liver ischemia-reperfusion: the major role of the alarmin interleukin-33

Frontiers in Immunology, 2023
Over the past thirty years, the complexity of the αβ-T cell compartment has been enriched by the identification of innate-like T cells (ITCs), which are composed mainly of invariant natural killer T (iNKT) cells and mucosal-associated invariant T (MAIT ...
Aurélie Robin, Claire Mackowiak, Romain Bost, Fanny Dujardin, Alice Barbarin, Antoine Thierry, Thierry Hauet, Luc Pellerin, Jean-Marc Gombert, Ephrem Salamé, André Herbelin, Louise Barbier   +11 more
doaj   +1 more source

Unconventional immune cells in the gut mucosal barrier: regulation by symbiotic microbiota

Experimental and Molecular Medicine, 2023
The mammalian gut is the most densely colonized organ by microbial species, which are in constant contact with the host throughout life. Hosts have developed multifaceted cellular and molecular mechanisms to distinguish and respond to benign and ...
Ji-Sun Yoo, Sungwhan F. Oh
doaj   +1 more source

Role of Oxidative Stress in Reperfusion following Myocardial Ischemia and Its Treatments

Oxidative Medicine and Cellular Longevity, 2021
Myocardial ischemia is a disease with high morbidity and mortality, for which reperfusion is currently the standard intervention. However, the reperfusion may lead to further myocardial damage, known as myocardial ischemia/reperfusion injury (MI/RI ...
M. Xiang, Yingdong Lu, Laiyun Xin, Jialiang Gao, Chang Shang, Zhilin Jiang, Hongchen Lin, Xuqin Fang, Yi Qu, Yuling Wang, Zihuan Shen, Mingjing Zhao, Xiangning Cui   +12 more
semanticscholar   +1 more source

Pharmacological brain cytoprotection in acute ischaemic stroke — renewed hope in the reperfusion era

Nature Reviews Neurology, 2022
For over 40 years, attempts to develop treatments that protect neurons and other brain cells against the cellular and biochemical consequences of cerebral ischaemia in acute ischaemic stroke (AIS) have been unsuccessful.
M. Fisher, S. Savitz
semanticscholar   +1 more source

Reactive Oxygen Species Induce Fatty Liver and Ischemia-Reperfusion Injury by Promoting Inflammation and Cell Death

Frontiers in Immunology, 2022
Liver transplantation is the ultimate method for treating end-stage liver disease. With the increasing prevalence of obesity, the number of patients with non-alcoholic fatty liver, a common cause of chronic liver disease, is on the rise and may become ...
S. Tang, Xinli Mao, Ya-Hong Chen, Ling-Ling Yan, Li-Ping Ye, Shao-wei Li   +5 more
semanticscholar   +1 more source