Results 31 to 40 of about 468,820 (359)

Clinical expression of plakophilin-2 mutations in familial arrhythmogenic right ventricular cardiomyopathy [PDF]

, 2006
Background - Arrhythmogenic right ventricular cardiomyopathy (ARVC) is an inherited cardiac disorder characterized by loss of cardiomyocytes and their replacement by adipose and fibrous tissue.
Asimaki, A, Ebrahim, HY, Elliott, PM, Evans, A, Hitomi, N, McKenna, WJ, Norman, M, Pantazis, A, Sen-Chowdhry, S, Shaw, AL, Syrris, P, Ward, D   +11 more
core   +1 more source

Human macrophages differentially produce specific resolvin or leukotriene signals that depend on bacterial pathogenicity

Nature Communications, 2018
Proinflammatory eicosanoids (prostaglandins and leukotrienes) and specialized pro-resolving mediators (SPM) are temporally regulated during infections.
Oliver Werz, Jana Gerstmeier, Stephania Libreros, Xavier De la Rosa, Markus Werner, Paul C. Norris, Nan Chiang, Charles N. Serhan   +7 more
doaj   +1 more source

Animal models of ischaemic stroke and characterisation of the ischaemic penumbra [PDF]

, 2018
Over the past forty years, animal models of focal cerebral ischaemia have allowed us to identify the critical cerebral blood flow thresholds responsible for irreversible cell death, electrical failure, inhibition of protein synthesis, energy depletion ...
Arroja, Mariana M., Macrae, I. Mhairi, McCabe, Christopher, Reid, Emma   +3 more
core   +1 more source

Predictors of clinical outcomes after cardiac resynchronization therapy in patients ≥75 years of age: a retrospective cohort study

BMC Geriatrics, 2019
Background Cardiac resynchronization therapy has been shown to benefit selected patients with heart failure and reduced ejection fraction. Older patients have been underrepresented in randomized trials.
Laure Champ-Rigot, Anne-Laure Cornille, Pierre Ollitrault, Arnaud Pellissier, Mathieu Chequel, Damien Legallois, Paul Milliez   +6 more
doaj   +1 more source

Fortelyzin® in the treatment of ischemic stroke. Case report

Consilium Medicum, 2023
Given the current high incidence of cerebral circulatory disorders and the challenging treatment of such patients, developing therapies and medications for these conditions is urgent.
Sarbinaz T. Ubushieva, Dmitry N. Kazakov, Anastasiya Yu. Lebedeva   +2 more
doaj   +1 more source

Endothelin and the ischaemic heart [PDF]

, 2005
Soon after its identification as a powerful vasoconstrictor peptide, endothelin (ET-1) was implicated as a detrimental agent involved in determining the outcome of myocardial ischaemia and reperfusion.
Kane, K.A., McCabe, C., Wainwright, C.L.
core   +1 more source

The P2X4 purinergic receptor controls the autophagy-related release of small extracellular vesicles from mammary cancer cells under hypoxia

Cell Communication and Signaling
Background Small extracellular vesicles (sEVs) are critical mediators of cell communications and are influenced by cellular stress. This study investigates the role of P2X4 and P2X7 purinoreceptors in the biogenesis and release of sEVs from triple ...
Thomas Duret, Mohammed Elmallah, Audrey Heraud-Meley, Cloé Tessier, Ana Valeria Vinhais Da Silva, Stéphanie Chadet, Roxane Lemoine, Justine Gainche, Valérie Labas, Ana-Paula Teixeira-Gomes, Daniel Tomas, Vesna Cuplov, Lin-Hua Jiang, Lili Fan, Gang Yin, Christophe Baron, Sébastien Roger   +16 more
doaj   +1 more source

Left ventricular function assessment using 123I/99mTc dual-isotope acquisition with two semi-conductor cadmium–zinc–telluride (CZT) cameras: a gated cardiac phantom study

EJNMMI Physics, 2016
Background The impact of increased energy resolution of cadmium–zinc–telluride (CZT) cameras on the assessment of left ventricular function under dual-isotope conditions (99mTc and 123I) remains unknown. The Amsterdam-gated dynamic cardiac phantom (AGATE,
Tanguy Blaire, Alban Bailliez, Fayçal Ben Bouallegue, Dimitri Bellevre, Denis Agostini, Alain Manrique   +5 more
doaj   +1 more source

Reperfusion injury

Clinical Cardiology, 1990
AbstractThis article reviews the early and late morphologic changes associated with reperfusion of ischemic myocardium. If instituted within minutes of coronary artery occlusion, all reversibly injured myocardium is salvaged. Once some irreversibly injured myocardium is present, the usually bland region of coagulation necrosis is transformed into an ...
openaire   +2 more sources

Recanalization and reperfusion in acute ischemic stroke. [PDF]

, 2010
Revascularization remains the most intuitive strategy to reverse ischemic injury associated with arterial occlusion in acute stroke. Revascularization may lead to opening of an occluded artery, or recanalization, yet restoration of downstream flow, or ...
Liebeskind, David S
core   +2 more sources