Results 51 to 60 of about 2,176,828 (392)

Heat Shock Protein 70 Protects the Heart from Ischemia/Reperfusion Injury through Inhibition of p38 MAPK Signaling. [PDF]

, 2020
BackgroundHeat shock protein 70 (Hsp70) has been shown to exert cardioprotection. Intracellular calcium ([Ca2+]i) overload induced by p38 mitogen-activated protein kinase (p38 MAPK) activation contributes to cardiac ischemia/reperfusion (I/R) injury ...
Chen, Qing-Cai, Ji, Fu-Hai, Liu, Hong, Liu, Hua-Yue, Ma, Jiao, Meng, Xiao-Wen, Peng, Ke, Song, Nan, Song, Shao-Yong, Wang, Hui, Zhang, Juan   +10 more
core   +1 more source

Ischemia/Reperfusion Injury Revisited: An Overview of the Latest Pharmacological Strategies

International Journal of Molecular Sciences, 2019
Ischemia/reperfusion injury (IRI) permeates a variety of diseases and is a ubiquitous concern in every transplantation proceeding, from whole organs to modest grafts.
Ricardo O S Soares, D. M. Losada, M. C. Jordani, P. Évora, O. Castro-e-Silva   +4 more
semanticscholar   +1 more source

Ceramide and Ischemia/Reperfusion Injury [PDF]

Journal of Lipids, 2018
Ceramide, a bioactive membrane sphingolipid, functions as an important second messenger in apoptosis and cell signaling. In response to stresses, it may be generated by de novo synthesis, sphingomyelin hydrolysis, and/or recycling of complex sphingolipids.
Xingxuan He, Edward H. Schuchman
openaire   +3 more sources

A feedback mechanism between PLD and deadenylase PARN for the shortening of eukaryotic poly(A) mRNA tails that is deregulated in cancer cells

Biology Open, 2017
The removal of mRNA transcript poly(A) tails by 3′→5′ exonucleases is the rate-limiting step in mRNA decay in eukaryotes. Known cellular deadenylases are the CCR4-NOT and PAN complexes, and poly(A)-specific ribonuclease (PARN).
Taylor E. Miller, Julian Gomez-Cambronero   +1 more
doaj   +1 more source

Blocking neutrophil integrin activation prevents ischemia-reperfusion injury. [PDF]

, 2015
Neutrophil recruitment, mediated by β2 integrins, combats pyogenic infections but also plays a key role in ischemia-reperfusion injury and other inflammatory disorders.
Ginsberg, Mark H, Liu, Zhenghui, McEver, Rodger P, Petrich, Brian G, Shao, Bojing, Yago, Tadayuki, Zhang, Nan   +6 more
core   +2 more sources

Myocardial ischemia-reperfusion injury: a neglected therapeutic target.

Journal of Clinical Investigation, 2013
Acute myocardial infarction (MI) is a major cause of death and disability worldwide. In patients with MI, the treatment of choice for reducing acute myocardial ischemic injury and limiting MI size is timely and effective myocardial reperfusion using ...
D. Hausenloy, D. Yellon
semanticscholar   +1 more source

Hypertension, hypertrophy, and reperfusion injury [PDF]

Journal of Cardiovascular Medicine, 2017
The heart of patients with hypertension and cardiac hypertrophy is more vulnerable to ischemia-reperfusion injury (IRI). Here we discuss the main mechanisms of IRI and possible targets for cardioprotection. In particular, we consider the viewpoint that hypertension and cardiac hypertrophy may act synergistically in increasing the predisposition to ...
PAGLIARO, Pasquale, PENNA, Claudia
openaire   +3 more sources

Postconditioning protects against endothelial ischemia-reperfusion injury in the human forearm [PDF]

, 2006
Background: Hypoxic cell death follows interruption of blood supply to tissues. Although successful restoration of blood flow is mandatory for salvage of ischemic tissues, reperfusion can paradoxically place tissues at risk of further injury.
Deanfield, J.E., Loukogeorgakis, S.P., MacAllister, R.J., Panagiotido, A.T., Yellon, D.M.   +4 more
core  

Does reperfusion injury still cause significant mortality after lung transplantation? [PDF]

, 2009
ObjectivesSevere reperfusion injury after lung transplantation has mortality rates approaching 40%. The purpose of this investigation was to identify whether our improved 1-year survival after lung transplantation is related to a change in reperfusion ...
Ailawadi, Gorav, Fedoruk, Lynn M., Hennessy, Sara A., Jones, David R., Kozower, Benjamin D., Kron, Irving L., Kuhn, Courtney J., Lau, Christine L., Smith, Philip W., Swenson, Brian R.   +9 more
core   +1 more source

Detecting rs‐fMRI Networks in Disorders of Consciousness: Improving Clinical Interpretability

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Preserved resting‐state functional MRI (rs‐fMRI) networks are typically observed in Disorders of Consciousness (DOC). Despite the widespread use of rs‐fMRI in DOC, a systematic assessment of networks is needed to improve the interpretability of data in clinical practice.
Jean Paul Medina Carrion, Mario Stanziano, Ludovico D'Incerti, Davide Sattin, Stefania Ferraro, Davide Rossi Sebastiano, Francesca Giulia Magnani, Alice Deruti, Davide Fedeli, Ludovico Minati, Francesca Epifani, Marina Grisoli, Matilde Leonardi, Maria Grazia Bruzzone, Anna Nigri, Cristina Rosazza   +15 more
wiley   +1 more source