Results 71 to 80 of about 819,894 (311)
Diversity and complexity in neural organoids
FEBS Letters, EarlyView.Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley +1 more source
Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation
FEBS Letters, EarlyView.Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz +11 more
wiley +1 more source
Molecular Oncology, EarlyView.Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra +10 more
wiley +1 more source
Molecular Oncology, EarlyView.Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice +16 more
wiley +1 more source
Improved Sliding Mode Control for Permanent Magnet Synchronous Motor Speed Regulation System
Applied Sciences, 2018 Due to advantages such as high speed, high accuracy, low maintenance and high reliability, permanent magnet synchronous motor (PMSM) servo systems have been employed in many fields.
Junbing Qian +3 more
doaj +1 more source
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
Adaptive Feedforward Cancellation for Precise Repetitive Motion in Coarse-Fine Control System
IEEE AccessThis paper introduces a novel control scheme to achieve precise repetitive motion within a dual-input-single-output (DISO) system consisting of course-actuator and fine-actuator.
Shota Yabui +3 more
doaj +1 more source
Phase correction for Learning Feedforward Control [PDF]
, 2003 Intelligent mechatronics makes it possible to compensate for effects that are difficult to compensate for by construction or by linear control, by including some intelligence into the system. The compensation of state dependent effects, e.g.
Kruif, Bas J. de, Vries, Theo J.A. de
core +2 more sources
LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro
Molecular Oncology, EarlyView.Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix +13 more
wiley +1 more source
A Family of Fundamental Positive Sequence Detectors Based on Repetitive Schemes
EnergiesIn electrical power systems, the extraction of the fundamental positive sequence (FPS) is paramount for synchronization, power calculation, and a wide variety of metering and control tasks.
Glendy Anyali Catzin-Contreras +3 more
doaj +1 more source