eLife, 2017 Some RNAs in mammalian cells can help to silence the DNA they are transcribed from.
Nahid Iglesias, Danesh Moazed
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Interstrand crosslinking oligonucleotides elucidate the effect of metal ions on the methylation status of repetitive DNA elements [PDF]
Frontiers in Chemistry, 2023 DNA methylation plays an important physiological function in cells, and environmental changes result in fluctuations in DNA methylation levels. Metal ions have become both environmental and health concerns, as they have the potential to disrupt the ...
Shan Liu +4 more
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Homologous recombination within repetitive DNA. [PDF]
Curr Opin Genet Dev, 2021 Many microsatellite DNA sequences are able to form non-B form DNA secondary structures, such as hairpin loops, cruciforms, triplex DNA or G-quadruplexes. These DNA structures can form a significant impediment to DNA replication and repair, leading to DNA nicks, gaps, and breaks, which can be repaired by homologous recombination (HR).
Polleys EJ, Freudenreich CH.
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Challenges and Approaches to Genotyping Repetitive DNA [PDF]
G3: Genes, Genomes, Genetics, 2020 Individuals within a species can exhibit vast variation in copy number of repetitive DNA elements. This variation may contribute to complex traits such as lifespan and disease, yet it is only infrequently considered in genotype-phenotype associations ...
Elizabeth A. Morton +9 more
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Substantial structural variation and repetitive DNA content contribute to intraspecific plastid genome evolution [PDF]
BMC GenomicsBackground Plastids have highly conserved genomes in most land plants. However, in several families, plastid genomes exhibit high rates of nucleotide substitution and structural rearrangements among species.
Alfredo López-Caamal +3 more
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Impact of Repetitive DNA Elements on Snake Genome Biology and Evolution [PDF]
Cells, 2021 The distinctive biology and unique evolutionary features of snakes make them fascinating model systems to elucidate how genomes evolve and how variation at the genomic level is interlinked with phenotypic-level evolution.
Syed Farhan Ahmad +3 more
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The mechanism of replication stalling and recovery within repetitive DNA [PDF]
Nature Communications, 2022 DNA replication of repetitive sequences was recreated in a test tube using purified components. DNA alone was sufficient to induce stalling. Both stalling and recovery were dictated by the capacity of DNA to fold into unusual secondary structures.
Corella S. Casas-Delucchi +3 more
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Cloning and physical localization of male-biased repetitive DNA sequences in Spinacia oleracea (Amaranthaceae) [PDF]
Comparative Cytogenetics, 2021 Spinach (Spinacia oleracea Linnaeus, 1753) is an ideal material for studying molecular mechanisms of early-stage sex chromosome evolution in dioecious plants. Degenerate oligonucleotide-primed polymerase chain reaction (DOP-PCR) technique facilitates the
Jian Zhou +8 more
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Tigerfish designs oligonucleotide-based in situ hybridization probes targeting intervals of highly repetitive DNA at the scale of genomes [PDF]
Nature CommunicationsFluorescent in situ hybridization (FISH) is a powerful method for the targeted visualization of nucleic acids in their native contexts. Recent technological advances have leveraged computationally designed oligonucleotide (oligo) probes to interrogate ...
Robin Aguilar +5 more
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Repetitive DNA profile of the amphibian mitogenome [PDF]
BMC Bioinformatics, 2020 Background Repetitive DNA elements such as direct and inverted repeat sequences are present in every genome, playing numerous biological roles. In amphibians, the functions and effects of the repeat sequences have not been extensively explored.
Noel Cabañas +5 more
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