Results 21 to 30 of about 152,959 (253)

Directed PCR-free engineering of highly repetitive DNA sequences

BMC Biotechnology, 2011
Background Highly repetitive nucleotide sequences are commonly found in nature e.g. in telomeres, microsatellite DNA, polyadenine (poly(A)) tails of eukaryotic messenger RNA as well as in several inherited human disorders linked to trinucleotide repeat ...
Preissler Steffen, Scior Annika, Koch Miriam, Deuerling Elke   +3 more
doaj   +1 more source

DeepGRP: engineering a software tool for predicting genomic repetitive elements using Recurrent Neural Networks with attention

Algorithms for Molecular Biology, 2021
Background Repetitive elements contribute a large part of eukaryotic genomes. For example, about 40 to 50% of human, mouse and rat genomes are repetitive. So identifying and classifying repeats is an important step in genome annotation.
Fabian Hausmann, Stefan Kurtz
doaj   +1 more source

Evolutionary rates and patterns for human transcription factor binding sites derived from repetitive DNA

BMC Genomics, 2008
Background The majority of human non-protein-coding DNA is made up of repetitive sequences, mainly transposable elements (TEs). It is becoming increasingly apparent that many of these repetitive DNA sequence elements encode gene regulatory functions ...
McDonald John F, Landsman David, Mariño-Ramírez Leonardo, Polavarapu Nalini, Jordan I King   +4 more
doaj   +1 more source

Analysis of repeat elements in the Pristionchus pacificus genome reveals an ancient invasion by horizontally transferred transposons

BMC Genomics, 2022
Background Repetitive sequences and mobile elements make up considerable fractions of individual genomes. While transposition events can be detrimental for organismal fitness, repetitive sequences form an enormous reservoir for molecular innovation.
Marina Athanasouli, Christian Rödelsperger   +1 more
doaj   +1 more source

Normalization of genomic DNA using duplex-specific nuclease

BioTechniques, 2010
An application of duplex-specific nuclease (DSN) normalization technology to whole-genome shotgun sequencing of genomes with a large proportion of repetitive DNA is described.
Irina Shagina, Ekaterina Bogdanova, Ilgar Z. Mamedov, Yury Lebedev, Sergey Lukyanov, Dmitry Shagin   +5 more
doaj   +1 more source

Chromosomal Differentiation of Deschampsia (Poaceae) Based on Four Satellite DNA Families

Frontiers in Genetics, 2021
Diverse families of satellite DNA (satDNA) were detected in heterochromatin regions of Deschampsia. This kind of repetitive DNA consists of tandem repeat sequences forming big arrays in genomes, and can contribute to lineages differentiation.
María Laura González, Jorge Oscar Chiapella, Juan Domingo Urdampilleta   +2 more
doaj   +1 more source

Epigenetics and triplet repeat neurological diseases

Frontiers in Neurology, 2015
The term ‘junk DNA’ has been reconsidered following the delineation of the functional significance of repetitive DNA regions. Typically associated with centromeres and telomeres, DNA repeats are found in nearly all organisms throughout their genomes ...
Sathiji eNageshwaran, Richard eFestenstein   +1 more
doaj   +1 more source

Contrasting the Chromosomal Organization of Repetitive DNAs in Two Gryllidae Crickets with Highly Divergent Karyotypes. [PDF]

PLoS ONE, 2015
A large percentage of eukaryotic genomes consist of repetitive DNA that plays an important role in the organization, size and evolution. In the case of crickets, chromosomal variability has been found using classical cytogenetics, but almost no ...
Octavio M Palacios-Gimenez, Carlos Roberto Carvalho, Fernanda Aparecida Ferrari Soares, Diogo C Cabral-de-Mello   +3 more
doaj   +1 more source

The genome organization of repetitive sequences in the Golden Damselfish, Amblyglyphidodon aureus (Cuvier, 1830) (Family Pomacentridae): insights from extensive pericentric inversions

Caryologia
The genus Amblyglyphidodon (damselfishes) is one of the most distinctive fish groups in the Indo-Pacific coral reef ecosystem. It consists of 11 recognized species, which display complex taxonomic relationships and cryptic lineages across their extensive
Nuntaporn Getlekha, Kamika Sribenja
doaj   +1 more source

Neutral mutations and repetitive DNA

Bioscience Reports, 1987
We have previously shown that computer simulations of processes that generate selectively advantageous changes together with random duplications and deletions give rise to genomes with many different genes embedded in a large amount of dispensable DNA sequence. We now explore the consequences of neutral changes on the evolution of genomes.
W F, Loomis, M E, Gilpin
openaire   +2 more sources