Results 31 to 40 of about 419 (189)
Delineation of individual human chromosomes in metaphase and interphase cells by in situ suppression hybridization using recombinant DNA libraries [PDF]
, 1988 A method of in situ hybridization for visualizing individual human chromosomes from pter to qter, both in metaphase spreads and interphase nuclei, is reported.Cremer, Thomas, Manuelidis, L., Lichter, Peter, Borden, J., Ward, D. C. +4 morecore +1 more sourceSomatic mutational landscape in von Hippel–Lindau familial hemangioblastoma
Molecular Oncology, EarlyView.The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen +5 morewiley +1 more sourceUnique and conserved MicroRNAs in wheat chromosome 5D revealed by next-generation sequencing [PDF]
, 2013 MicroRNAs are a class of short, non-coding, single-stranded RNAs that act as post-transcriptional regulators in gene expression. miRNA analysis of Triticum aestivum chromosome 5D was performed on 454 GS FLX Titanium sequences of flow sorted chromosome 5D Hikmet Budak (150694), Melda Kantar, Kurtoglu Kuaybe Yucebilgili, Lucas, Stuart J., Stuart J. Lucas (150688), Stuart J Lucas, Budak, Hikmet, Yucebilgili, Kuaybe, Melda Kantar (402943), Kuaybe Yucebilgili Kurtoglu (436352), Lucas Stuart J., Kantar Melda, Hikmet Budak, Budak Hikmet, Kantar, Melda, Kuaybe Yucebilgili Kurtoglu +15 morecore +1 more sourceHippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer
Molecular Oncology, EarlyView.Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà +11 morewiley +1 more sourceTwo new rapid SNP-typing methods for classifying Mycobacterium tuberculosis complex into the main phylogenetic lineages [PDF]
, 2012 There is increasing evidence that strain variation in Mycobacterium tuberculosis complex (MTBC) might influence the outcome of tuberculosis infection and disease.Coscollà Mireia, David Stucki, Feldmann, Julia, Yeboah-Manu, D., Comas Iñaki, Gagneux, Sebastien, Hostettler Simon, Simon Hostettler, Thembela Huna (149818), Huna, Thembela, Huna Thembela, Malla Bijaya, Mireia Coscollà, Julia Feldmann (149820), Feldmann Julia, Stucki, David, Iñaki Comas (57109), Thembela Huna, Hostettler, S., Comas, Iñaki, Malla, Bijaya, Stucki David, Dorothy Yeboah-Manu, Sonia Borrell, David Stucki (149811), Huna, T., Gagneux, S., Yeboah-Manu, Dorothy, Fenner, Lukas, Borrell, Sonia, Dorothy Yeboah-Manu (120059), Comas, I., Bijaya Malla, Gagneux Sebastien, Fenner, L., Borrell Sonia, Hostettler, Simon, Lukas Fenner, Fenner Lukas, Bijaya Malla (149813), Sebastien Gagneux (149824), Mireia Coscollà (149823), Coscollà, Mireia, Sebastien Gagneux, Malla, B., Simon Hostettler (149816), Sonia Borrell (149821), Borrell, S., Julia Feldmann, Coscolla, M., Yeboah-Manu Dorothy, Lukas Fenner (149822), Iñaki Comas, Feldmann, J., Stucki, D. +54 morecore +1 more sourceTranscriptional profiling of circulating extracellular vesicles from prebiopsy prostate cancer patients
Molecular Oncology, EarlyView.RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...Stefan Werner, Pierre Tennstedt, Randi C. Pose, Christian Müller, Katharina Besler, Svenja Schneegans, Malik Alawi, Marie C. Roesch, Sven Peine, Desiree Bonci, Joanna Budna‐Tukan, Evi Lianidou, Catherine Alix‐Panabières, Derya Tilki, Klaus Pantel +14 morewiley +1 more sourceLongitudinal circulating tumor DNA profiling in patients with advanced endometrial cancer using an off‐the‐shelf targeted NGS panel
Molecular Oncology, EarlyView.Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...Carlos Casas‐Arozamena, Karin Teien Lande, Eva Diaz, Ana Vilar, Juan Cueva, Efigenia Arias, Victoria Sampayo, Alicia Abalo, Nerea González, Eva Colás, Antonio Gil‐Moreno, Miguel Abal, Gema Moreno‐Bueno, Therese Sørlie, Kristina Lindemann, Laura Muinelo‐Romay +15 morewiley +1 more sourceClinical performance of the urine‐based TERT promoter AbsoluteQ Digital PCR for non‐invasive detection of bladder cancer
Molecular Oncology, EarlyView.A urine‐based digital PCR assay targeting two hotspot TERT promoter variants detected bladder cancer with high sensitivity and no false positives in this case–control cohort. The streamlined AbsoluteQ workflow outperformed Sanger sequencing and supports non‐invasive molecular testing for bladder cancer detection.Anna Nykel, Izabela Kubiak, Lena Rutkowska, Żaneta Kasprzyk, Łukasz Kępczyński, Michał Bednarek, Dariusz Sobieraj, Jacek Wilkosz, Piotr Kania, Adam Jędrzejczyk, Bogdan Kałużewski, Agnieszka Gach, Tadeusz Kałużewski +12 morewiley +1 more sourceAlu sequences
, 1997 Alu sequences are frequently encountered during study of human genomic nucleic acid and form a major component of repetitive DNA. This review describes the origin of Alu sequences and their subsequent amplification and evolution into distinct subfamilies.A.J. Mighell, A.F. Markham, P.A. Robinson, Robinson, P.A., Mighell, A.J., Markham, A.F. +5 morecore +1 more sourceGenomic and genetic analyses of diversity and plant interactions of Pseudomonas fluorescens [PDF]
, 2009 Background: Pseudomonas fluorescens are common soil bacteria that can improve plant health through nutrient cycling, pathogen antagonism and induction of plant defenses. The genome sequences of strains SBW25 and Pf0-1 were determined and compared to each Mavromatis, K, Zhang, Xue-Xian, Giddens, Stephen R, Preston, Gail, Yaxley, Alice M., Yaxley, A. M., Hothersall, Joanne, Christopher G Knight, Christina D Moon, Jackson, RW, Gregory L Challis, Ana M Cerdeño-Tárraga, Robert W Jackson, Godfrey, Scott A. C., Murphy, Lee, Seeger, K, Spiers, AJ, Levy, SB, Preston, G. M., Godfrey, Scott A C, Rainey, PB, Cerdeño-Tárraga, Ana M, Gehrig, Stefanie M, Jacob G Malone, Gehrig, S. M., Paul B Rainey, Silby, M. W., Challis, GL, Thomson, N. R., Challis, Gregory L, Hothersall, J, Stephens, E, Andrew J Spiers, Zhang, Xue Xian, Elton Stephens, Gehrig, Stefanie M., Thomas, C. M., Nicholas R Thomson, Lee Murphy, Parkhill, J., Gehrig, SM, Spiers, A. J., Godfrey, Scott AC, Squares, Rob, Robinson, Z., Levy, S. B., Malone, Jacob G., Harris, S., Vernikos, Georgios S., Mavromatis, Konstantinos, Giddens, SR, Yaxley, AM, Quail, Michael A., Stephen R Giddens, Silby, Mark W, Quail, M. A., Stephen D Bentley, Brettin, T. S., Brettin, TS, Cerdeño-Tárraga, AM, Vernikos, GS, Challis, G. L., Seeger, K., Julian Parkhill, Saunders, E., Vernikos, G. S., Knight, C. G., Moon, C. D., Quail, Michael A, Georgios S Vernikos, Spiers, Andrew J., Parkhill, Julian, Moon, CD, Kathy Seeger, Preston, Gail M., Mavromatis, K., Joanne Hothersall, Giddens, Stephen R., Murphy, L, Jackson, Robert W, Godfrey, S. A. C., Mark W Silby, Zhang, XX, Knight, Christopher G, Thomas S Brettin, Levy, Stuart B., Thomas, CM, Thomson, NR, Murphy, L., Zhang, X. X., Harris, D., Jackson, Robert W., Murphy, L., Malone, J. G., Quail, MA, Konstantinos Mavromatis, Stuart B Levy, Knight, Christopher G., Silby, MW, Parkhill, J, Moon, Christina D, Rutter, S, Rutter, Simon, Christopher M Thomas, Xue-Xian Zhang, Stephens, E., Bentley, Stephen D, Harris, D., Thomas, Christopher M., Bentley, Stephen D., Zena Robinson, Alice M Yaxley, Stephens, Elton, Vernikos, Georgios S, Knight, C. G., Harris, Simon, David Harris, Robinson, Z., Knight, Christopher G.; id_orcid, Hothersall, J., Bentley, S. D., Scott AC Godfrey, Giddens, S. R., Thomson, Nicholas R, Thomson, Nicholas R., Stefanie M Gehrig, Moon, Christina D., Robinson, Z, Squares, R, Saunders, Elizabeth, Simon Harris, Elizabeth Saunders, Gail M Preston, Godfrey, SA, Bentley, SD, Jackson, R. W., Rainey, Paul B., Rob Squares, Rainey, Paul B, Rainey, P. B., Knight, CG, Cerdeno-Tarraga, A. M., Cerdeño-Tárraga, Ana M., Seeger, Kathy, Harris, S, Preston, Gail M, Rutter, S., Thomas, Christopher; id_orcid, Thomas, Christopher M, Brettin, Thomas S, Thomson, Nicholas Robert, Michael A Quail, Silby, Mark W., Spiers, Andrew J, Squares, R., Saunders, E, Challis, Gregory L., Simon Rutter, Malone, JG, Preston, GM, Harris, D, Robinson, Zena, Saunders, E., Malone, Jacob G, Yaxley, Alice M, Levy, Stuart B, Harris, David, Brettin, Thomas S. +167 morecore +1 more source
