Results 21 to 30 of about 3,522,596 (141)

The ALS/FTD-related C9orf72 hexanucleotide repeat expansion forms RNA condensates through multimolecular G-quadruplexes

open access: yesNature Communications, 2023
Amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) are neurodegenerative diseases that exist on a clinico-pathogenetic spectrum, designated ALS/FTD.
Federica Raguseo   +15 more
doaj   +1 more source

RNA-dependent stabilization of SUV39H1 at constitutive heterochromatin

open access: yeseLife, 2017
Heterochromatin formed by the SUV39 histone methyltransferases represses transcription from repetitive DNA sequences and ensures genomic stability. How SUV39 enzymes localize to their target genomic loci remains unclear.
Whitney L Johnson   +7 more
doaj   +1 more source

Dual‐mode biosensing platform for ultrasensitive Salmonella detection based on cascaded signal amplification coupled with DNA‐functionalized Ag2S NPs@PB

open access: yesFood Frontiers, 2023
Salmonella is one of the most common zoonotic foodborne pathogens and can cause serious threats to public health and global economy. A dual‐mode biosensing platform was demonstrated based on cascaded signal amplification coupled with DNA‐functionalized ...
Jing‐bo Jiao   +9 more
doaj   +1 more source

Molecular cytogenetic mapping of Cucumis sativus and C. melo using highly repetitive DNA sequences [PDF]

open access: yes, 2010
Chromosomes often serve as one of the most important molecular aspects of studying the evolution of species. Indeed, most of the crucial mutations that led to differentiation of species during the evolution have occurred at the chromosomal level ...
Jong, J.H.S.G.M., de   +6 more
core   +1 more source

STR technique for the detection of contamination by exogenous DNA in paraffin blocks and histological slides

open access: yesSurgical and Experimental Pathology, 2019
Gastrointestinal Stromal Tumors (GIST) present different types of mutations that may or may not be sensitive to specific target therapy. The laboratory procedure required to prepare histological sections traditionally demands multiple steps, making the ...
Denise Barcelos   +4 more
doaj   +1 more source

The mitochondrial genomes of sponges provide evidence for multiple invasions by Repetitive Hairpin-forming Elements (RHE) [PDF]

open access: yes, 2009
Background: The mitochondrial (mt) genomes of sponges possess a variety of features, which appear to be intermediate between those of Eumetazoa and non-metazoan opisthokonts.
Lavrov Dennis V   +11 more
core   +1 more source

Rapid capture of DNA targets

open access: yesBioTechniques, 2008
A rapid capture technique was developed to efficiently isolate specific DNA targets from a variety of genomes. The specificity can be easily adapted to any target for which partial sequence is known, allowing for the isolation of a wide set of target ...
Judy St. John, Thomas W. Quinn
doaj   +1 more source

Analysis of a c0t-1 library enables the targeted identification of minisatellite and satellite families in Beta vulgaris [PDF]

open access: yes, 2010
Zakrzewski F, Wenke T, Holtgräwe D, Weisshaar B, Schmidt T. Analysis of a c0t-1 library enables the targeted identification of minisatellite and satellite families in Beta vulgaris. BMC Plant Biology.
Zakrzewski, Falk   +14 more
core   +1 more source

The challenge of small-scale repeats for indel discovery

open access: yesFrontiers in Bioengineering and Biotechnology, 2015
Repetitive sequences are abundant in the human genome. Different classes of repetitive DNA sequences, including simple repeats, tandem repeats, segmental duplications, interspersed repeats and other elements, collectively span more than 50% of the genome.
Giuseppe eNarzisi, Michael C Schatz
doaj   +1 more source

General cell-binding activity of intramolecular G-quadruplexes with parallel structure.

open access: yesPLoS ONE, 2013
G-quadruplexes (G4s) are four-stranded nucleic acid structures adopted by some repetitive guanine-rich sequences. Putative G-quadruplex-forming sequences (PQSs) are highly prevalent in human genome.
Tianjun Chang   +7 more
doaj   +1 more source

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