Results 131 to 140 of about 28,497 (308)
ABSTRACT Introduction Major depressive disorder (MDD) affects 11%–19% of adolescents globally. Early treatment is vital, but the risk of relapse is high, with 46% relapse within 5 years, which threatens a chronic course. Hence, better solutions are needed.
Lidija Rakic +8 more
wiley +1 more source
Jakub Antczak,1 Katarzyna Kowalska,1 Aleksandra Klimkowicz-Mrowiec,1 Barbara Wach,2 Katarzyna Kasprzyk,1 Marta Banach,1 Karolina Rzeźnicka-Brzegowy,3 Jadwiga Kubica,3 Agnieszka Słowik1 1Department of Neurology, Jagiellonian University Medical College ...
Banach M +8 more
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Novel approaches for drug development against chronic primary pain: A systematic review
Abstract Chronic primary pain (CPP) persisting for more than 3 months, associated with significant emotional distress without any known underlying cause, is an unmet medical need. Traditional or adjuvant analgesics do not provide satisfactory pain relief for a great proportion of these patients.
Valéria Tékus +5 more
wiley +1 more source
Electrophysiological biomarkers in genetic movement disorders
BACKGROUND. Neurodegenerative diseases are diseases of the nervous system with progressive course leading to death. Treatment remains symptomatic. Development of neuroprotective agents has been hampered for various reasons. This includes the inability of
Schneider, K.S.A.I.M
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The aim of the study was to examine the effect of low-frequency repetitive transcranial magnetic stimulation on saccade triggering. In five participants, a train of 600 pulses with a frequency of 1 Hz was applied over the right frontal eye field and--as ...
von Wartburg, Roman +6 more
core +1 more source
Abstract Background and Purpose Chemotherapy‐induced peripheral neuropathy (CIPN) is a prevalent and treatment‐resistant side effect of platinum‐based chemotherapy, characterised by mechanical allodynia. Cannabigerol (CBG), a non‐psychoactive cannabinoid, has shown antinociceptive potential, but its site and mechanism of action remain unclear.
Quinn W. Wade +7 more
wiley +1 more source
Pengfei Cao,1,2,* Jun Xing,1,* Yin Cao,3 Qi Cheng,1 Xiaojing Sun,1 Qi Kang,1 Libin Dai,1 Xianju Zhou,3 Zixiang Song1 1Psychological Centre for Adolescents and Children, The Affiliated 102nd Hospital of The Second Military Medical University of People ...
Xing J +8 more
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Transcranial magnetic stimulation has evolved into a powerful neuroscientific tool allowing to interfere transiently with specific brain functions. In addition, repetitive TMS (rTMS) has long-term effects (e.g.
Schlaepfer, Thomas E +4 more
core +1 more source
Novel therapeutic targets for chronic visceral pain in gastrointestinal disorders
Chronic visceral pain imposes a major clinical challenge in gastroenterology and beyond, profoundly impacting patients' quality of life. However, limited understanding of its complex, multifaceted pathophysiology, encompassing both peripheral and central mechanisms, continues to impede the development of effective management strategies.
Fleur Veldman +3 more
wiley +1 more source
We investigated the effects of combined transcranial direct current stimulation (tDCS) and oral capsaicinoids on swallowing function in 21 healthy young adults. The combined cortical and peripheral sensory intervention could potentially facilitate swallowing.
Ivy Cheng, Sonja Suntrup‐Krüger
wiley +1 more source

