Results 151 to 160 of about 28,497 (308)

Innovations in Obesity Treatment: Beyond Adipose Tissue Dysfunction

Obesity Reviews, EarlyView.
Obesity drives chronic inflammation, insulin resistance, type 2 diabetes, and cancer development through adipocyte dysfunction. Addressing this multisystemic disorder requires integrated strategies beyond diet and exercise, such as thermogenesis activation via menthol or capsinoids and appetite control through GLP‐1/GIP agonists and neuromodulation to ...
Jesica Martínez‐Godfrey, Irene Pomares‐Bri, Paula de Juan‐Maciá, Mariló Olivares‐Vicente, Enrique Barrajón‐Catalán, Vicente Micol, Enrique Roche, María Herranz‐López   +7 more
wiley   +1 more source

Magnetic resonance spectroscopy in the evaluation of treatment efficacy in unipolar major depressive disorder: a review of the literature [PDF]

, 2012
More and more neuroimaging studies are using in vivo proton magnetic resonance spectroscopy (1H-MRS) to explore correlates of response to therapy in major depressive disorder (MDD). Their aim is to further understanding of the effects of neurotransmitter
A. Pichiecchio, F. Barale, M. Pasin, Biondi, Massimo, Palesi, Fulvia, Caverzasi, Edoardo, Pasquini, Massimo, G. Castellazzi, Bastianello, Stefano, A. Calligaro, Barale, Francesco, E. Caverzasi, Pichiecchio, Anna, Pasin, Marino, Castellazzi, Gloria, Calligaro, Alessandro, F. Palesi, Poloni, Guy, G. U. Poloni   +18 more
core  

Acute prefrontal hemodynamic responses to intermittent theta burst stimulation correlate with current depression and episode recurrence: A cross‐sectional study

Psychiatry and Clinical Neurosciences, EarlyView.
Background Mounting evidence has indicated that multiple major depressive disorder (MDD) episodes are correlated with brain morphometric changes that confer an increased recurrence risk. Functional abnormalities underlying this recurrent vulnerability remain underexplored.
Minxia Jin, Adam W.L. Xia, Wanda M.W. Chau, Nancy M.X.Y. Shi, Penny P. Qin, Bella B.B. Zhang, Rebecca L.D. Kan, Alvin H.P. Tang, Tim T.Z. Lin, Sharie X. Wang, Dicky W.S. Chung, Frank Padberg, Georg S. Kranz   +12 more
wiley   +1 more source

1 Hz Low-Frequency Repetitive Transcranial Magnetic Stimulation Ameliorates Epilepsy by Suppressing Interferon-γ Signaling-Dependent Microglial Synaptic Phagocytosis in Mice. [PDF]

CNS Neurosci Ther
In a mouse model of recurrent seizures, 1 Hz rTMS exerted neuroprotective effects by enhancing IFN‐γ‐dependent STAT2 activation in microglia and reducing CADM1/2/3 expression, thereby limiting excessive synaptic phagocytosis. Notably, co‐treatment with a neutralizing antibody against IFN‐γ abolished the 1 Hz rTMS‐induced STAT2 activation and the ...
Lin D, Wang D, Xiao N.
europepmc   +2 more sources

Motor learning and neuroplasticity in humans [PDF]

, 2009
The central nervous system is plastic, in that the number and strength of synaptic connections changes over time. In the adult the most important driver of such changes is experience, in the form of learning and memory. There are thought to be a number
Teo, J.T.H., Teo, J T H
core  

Regional changes in cerebral blood flow between the upright and supine posture and over 3 days of bed rest

Experimental Physiology, EarlyView.
Abstract A reduction in cerebral blood flow (CBF) has been observed during spaceflight and bed rest. We aimed to examine the magnitude and regional heterogeneity of the decrease in CBF during bed rest compared to posture changes on Earth. Seventeen participants (age, 29 ± 9 years, 7 females) were studied in the upright and supine posture and over 3 ...
Carmen Possnig, Kyohei Marume, Gautam Babu, Sylvan L. J. E. Janssen, Christopher M. Hearon Jr, Katrin A. Dias, Satyam Sarma, Justin S. Lawley, Benjamin D. Levine   +8 more
wiley   +1 more source

Cerebral blood flow regulation, central arterial stiffness and traumatic brain injury: Effects of aerobic exercise training

Experimental Physiology, EarlyView.
Abstract Advanced age is the strongest risk factor for Alzheimer's disease and related dementias (ADRDs). Traumatic brain injury (TBI) has also been recognized as a risk factor for ADRD, potentially contributing to an earlier onset of the disease. Thus, elucidating the mechanisms underlying brain ageing and TBI is critical for developing strategies to ...
Tsubasa Tomoto, Kan Ding, C. Munro Cullum, Rong Zhang   +3 more
wiley   +1 more source

Brain strain: Blood flow and metabolism in environmental extremes

Experimental Physiology, EarlyView.
Abstract This narrative review compares and contrasts the most commonly encountered environmental stressors on human cerebrovascular functioning. From high altitude and space, extreme apnoea, heat and cold stress, the impact of these stressors on the regulation of cerebral blood flow (CBF) and oxygen metabolism (CMRO2${\mathrm{CM}}{{\mathrm{R}}_ ...
Dario Vrdoljak, Damian M. Bailey, Travis D. Gibbons, Philip N. Ainslie   +3 more
wiley   +1 more source

Galvanic vestibular stimulation reveals disruption of ipsilesional brainstem pathways in hemiparetic stroke survivors

Experimental Physiology, EarlyView.
Abstract The spatiotemporal structure of muscle coordination emerges from the collaboration and competition among cortical, brainstem and spinal pathways onto motor neuron pools, each continuously shaped by task demands, limb position and descending tract integrity.
Angelo Bartsch‐Jiménez, Hesam Azadjou, Francisco J. Valero‐Cuevas   +2 more
wiley   +1 more source

Translational perspectives on neurophysiological responses and mechanisms in blood flow restriction exercise

Experimental Physiology, EarlyView.
Abstract Maintaining corticospinal tract function is crucial for voluntary movement. Exercise using high external loads/intensities is a promising intervention to promote adaptations to the corticospinal tract and improve physical function; however, such loads/intensities may not be tolerable or safe in populations with neurological disorders, motor ...
Kai T. Fox, Luke Hughes, Brendan R. Scott, Paul S. R. Goods, Shaun YM. Teo, Ann‐Maree Vallence   +5 more
wiley   +1 more source