Results 111 to 120 of about 3,207,924 (350)
Molecular Oncology, EarlyView.Loss of primary cilia in endothelial cells promotes EndMT and vascular abnormalities in the ovarian tumor microenvironment through EphA2 activation. Using human samples, in vitro models, and endothelial‐specific Kif3a‐knockout mice, we show that primary cilia loss drives the acquisition of cancer‐associated fibroblast‐like phenotypes, thereby ...
Jin Gu Cho +11 more
wiley +1 more source
A nucleotide‐independent, pan‐RAS‐targeted DARPin elicits anti‐tumor activity in a multimodal manner
Molecular Oncology, EarlyView.We report a Designed Ankyrin Repeat Protein that binds and inhibits RAS proteins, which serve as central cell signaling hubs and are essential for the progression of many cancers. Its unique feature is that it does not discriminate between different RAS isoforms or mutations and is capable of binding to RAS in both its active (GTP‐bound) and inactive ...
Jonas N. Kapp +13 more
wiley +1 more source
TRAUMATIC SHOCK. X. THE TREATMENT OF HEMORRHAGIC SHOCK IRREVERSIBLE TO REPLACEMENT OF BLOOD VOLUME DEFICIENCY 1 [PDF]
, 1945 Howard A. Frank +2 more
openalex +1 more source
To Replace or Not to Replace? Replacing Short Peripheral Catheters Based on Clinical Indication
Journal of Infusion Nursing, 2019 Short peripheral catheters (SPCs) are the most frequently used medical devices in hospital settings. Many hospital policies state that SPCs be replaced at 96 hours, which can be unnecessary and costly. A pre-post quality improvement initiative was implemented following complications surrounding removal of timed SPC catheters compared with those removed
openaire +5 more sources
Molecular Oncology, EarlyView.C–C chemokine receptor type 9 (CCR9) is an immune checkpoint in pancreatic ductal adenocarcinoma (PDAC). Novel anti‐CCR9 antibody SRB2 was evaluated in combination with cytotoxic chemotherapy in PDAC cells, patient‐derived organoids, patient‐derived xenografts, and humanized mouse models.
Hannah G. McDonald +18 more
wiley +1 more source
Anterior Subluxation after Total Hip Replacement Confirmed by Radiographs: Report of Two Cases
Advances in Orthopedics, 2011 Demonstrable anterior subluxation of the femoral head after a total hip arthroplasty is a rare complication and is usually transient. Both a case of recurrent subluxation and a case of chronic subluxation are described in this paper, each one presenting ...
Conor P. McGrory, Brian J. McGrory
doaj +1 more source
The Behaviour of Finely Ground Bottom Ash in Portland Cement
, 2009 The aim of this project was to assess the effects of finely ground MSWI bottom ash in Portland cement. Mortar mixes were prepared with 10% and 40% replacement of cement by ground IBA and then tested with regards to their material composition and ...
Black, L +4 more
core
The opportunistic replacement and inspection problem for components with a stochastic life time [PDF]
, 2011 The problem of finding efficient maintenance and inspection schemes in the case of components with a stochastic life time is studied and a mixed integer programming solution is proposed.
Bohlin, Markus +2 more
core +1 more source
British Labour: Replacement and Conciliation, 1914-21. [PDF]
, 1922 C. K. H., A. W. Kirkaldy
openalex +1 more source
Unraveling LINE‐1 retrotransposition in head and neck squamous cell carcinoma
Molecular Oncology, EarlyView.The novel RetroTest method allows the detection of L1 activation in clinical samples with low DNA input, providing global L1 activity and the identification of the L1 source element. We applied RetroTest to a real‐world cohort of HNSCC patients where we reported an early L1 activation, with more than 60% of T1 patients showing L1 activity.
Jenifer Brea‐Iglesias +12 more
wiley +1 more source