Results 71 to 80 of about 868,934 (253)
, 2020 Background and Objectives Blood safety and sufficiency are major challenges in Kenya and other sub-Saharan African countries forcing many countries to rely on family replacement donors (FRD).
R Kaiser +11 more
core
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
Journal of Aziz Fatimah Medical and Dental College, 2019 Background: Blood transfusion saves millions of lives worldwide each year and reduces morbidity but at the same time is a source for potentially life threatening transfusion transmissible infections (TTIs).
Sarwat Jahan +2 more
doaj +1 more source
Liver organoids: modelling complexity in homeostasis and disease
FEBS Letters, EarlyView.Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley +1 more source
Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry
FEBS Letters, EarlyView.EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri +5 more
wiley +1 more source
This dataset supports a research that seeks to determine the seroprevalence, trend, and risk factors of hepatitides among family replacement blood ...
Osei-Boakye, Felix
core +1 more source
Structural and biochemical analysis of a B12 superbinder
FEBS Letters, EarlyView.BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices +3 more
wiley +1 more source
Brave New World: A Literature Review of Emerging Donors and the Changing Nature of Foreign Assistanc- Working Paper 273 [PDF]
In this paper, we look at the scale and scope of emerging donors, many of which are developing economies themselves. On the basis of a survey of the literature, we find that estimates of annual aid flows from new donors (so-called non-DAC donors) vary ...
Vijaya Ramachandran, Julie Walz
core
Khyber Medical University Journal, 2017 OBJECTIVE: to determine iron deficiency in first time, replacement, voluntary and regular male blood donors and to detect pre-clinical iron deficiency in blood donors at tertiary care hospitals of Peshawar, Pakistan by assessing serum ferritin levels ...
Khadija Habib +4 more
doaj
Asian Journal of Medical Sciences, 2014 Objectives: To determine the seroprevalence of HBsAg in the prevalence of HBsAg positivity among male and female blood donors. Materials and Methods: A retrospective study was conducted in blood bank.
Prakash Murigeppa Patil
doaj +1 more source