Results 61 to 70 of about 2,816,049 (194)

Quality of life in patients with hypothyroidism

Клиническая и экспериментальная тиреоидология, 2010
To assess the quality of life of patients with hypothyroidism and to compare with the QoL of patients with nodular goiter and people without thyroid disease.

doaj   +1 more source

Antithrombotic therapy for coronary artery disease: the Seventh ACCP Conference on Antithrombotic and Thrombolytic Therapy.

, 2004
This chapter about antithrombotic therapy for coronary artery disease (CAD) is part of the Seventh ACCP Conference on Antithrombotic and Thrombolytic Therapy: Evidence Based Guidelines. Grade 1 recommendations are strong and indicate that the benefits do,
Christopher M. O'Connor, O'Connor, Christopher M, Meade, Thomas W, Guyatt, Gordon H, Becker, Richard C, David A. Vorchheimer, Harrington, Robert A, Michael Ezekowitz, Ezekowitz, Michael, Thomas W. Meade, Vorchheimer, David A, Gordon H. Guyatt, Robert A. Harrington, Richard C. Becker   +13 more
core   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Profiling mortality patterns and place of death in patients on maintenance hemodialysis: a retrospective study in a tertiary care academic hospital in India

BMC Palliative Care
Background End-stage kidney disease (ESKD) significantly burdens healthcare systems and increases mortality. In India, approximately 175,000 individuals are relying on maintenance hemodialysis (mHD).
Surya Gayathri M, Bharathi Naik, Arun Ghoshal, Anuja Damani, Shankar Prasad Nagaraju   +4 more
doaj   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Serum nicotine level among various tobacco users: A study

Journal of Indian Academy of Oral Medicine and Radiology, 2016
Introduction: The use of tobacco and its products has increased in the population over the past two decades, resulting in considerable systemic exposure to nicotine. Aims and Objectives: To estimate and compare the serum nicotine levels among smokers and
Dayanandam Mala, Pushpanjali, Venkateshwarlu Nallapu, Madhavi Ambati, Jitendar Reddy Kubbi, Jaya Krishna Bairi   +5 more
doaj   +1 more source

Transdermal testosterone replacement therapy in men [PDF]

, 2014
M Iftekhar Ullah,1 Daniel M Riche,1,2 Christian A Koch1,31Department of Medicine, University of Mississippi Medical Center, 2Department of Pharmacy Practice, The University of Mississippi, 3GV (Sonny) Montgomery VA Medical Center, Jackson, MS ...
Koch CA, Ullah MI, Riche DM
core  

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

Prospecting the protein design landscape

FEBS Letters, EarlyView.
This review outlines the current state of various protein design approaches. We discuss the current possibilities enabled by recently released tools, highlight future avenues to pursue in protein design, and underscore the crucial role of key databases and resources for successful protein design workflows.
Jakob R. Riccabona, Katharina T. Stonig, Jens Meiler, Clara T. Schoeder, Monica L. Fernández‐Quintero   +4 more
wiley   +1 more source

Ductal carcinoma In-Situ in turner syndrome patient undergoing hormone replacement therapy: A case report [PDF]

, 2016
Turner’s syndrome is a rare congenital disease which affects about 1 in every 2500-3000 live-born females. This happens due to chromosomal abnormalities in a phenotypic female, causing increased gonadotropin concentrations and low concentrations of ...
Matemavi, Praise; Department of Surgery, New York Presbyterian Queens Hospital/Weill Cornell Medical College, New York, Maizlin, Ilan; Department of Surgery, New York Presbyterian Queens Hospital/Weill Cornell Medical College, New York, Bawa, Rashmi; Department of Surgery, Pine Health Services, Maine, Sung, Kap-Jae; Department of Surgery, New York Presbyterian Queens Hospital/Weill Cornell Medical College, New York   +3 more
core   +3 more sources