Results 91 to 100 of about 108,626 (229)

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source

A successful intervention program for high ability minority students [PDF]

Among professional occupations in the United States, non-Asian minorities are least represented in science and engineering fields. The Bureau of Labor Statistics predicts that over the next decade, civilian employment of scientists and engineers has the ...
Coleman, Winson R.
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Inductions of physical education teachers in Europe

Revista da Educação Física, 2019
The purpose of this research was to explore the similarities and differences of existing induction systems for physical education (PE) teachers in Europe.
Deniz Hunuk, Zuleyha Avsar, Jaroslav Kupr, Erica Gobbi   +3 more
doaj  

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

Priorities for a New Decade: Making (More) Social Programs Work (Better) [PDF]

, 2011
In this whitepaper, P/PV proposes a comprehensive and bold re-thinking of how nonprofits are evaluated. Priorities for a New Decade puts forward an approach that fully engages practitioners as partners in evaluation efforts, reflects a deep understanding

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Crucial parameters for precise copy number variation detection in formalin‐fixed paraffin‐embedded solid cancer samples

Molecular Oncology, EarlyView.
This study shows that copy number variations (CNVs) can be reliably detected in formalin‐fixed paraffin‐embedded (FFPE) solid cancer samples using ultra‐low‐pass whole‐genome sequencing, provided that key (pre)‐analytical parameters are optimized.
Hanne Goris, Vasiliki Siozopoulou, Léon C van Kempen, Anne Sieben, Ella Roelant, Stig Hellemans, Elyne Backx, Laure Sorber, Koen De Winne, Senada Koljenović, Karen Zwaenepoel   +10 more
wiley   +1 more source

The Chelsea Foyer at the Christopher at Five Years: Lessons in Developing Stable Housing and Self-Sufficiency For Homeless Youth and Youth Exiting Foster Care [PDF]

, 2009
The Chelsea Foyer at the Christopher is a transitional housing program for youth aging out of foster care and youth who are homeless or at risk of becoming homeless.

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Acceptability, feasibility, and program outcomes of an equity-focused, adapted community-based healthy lifestyle program for children, young people, and their families in Perth, Western Australia: an implementation hybrid research protocol

Frontiers in Health Services
BackgroundInternational guidelines recommend multidisciplinary intervention programs for addressing childhood obesity. In Western Australia, community-based healthy lifestyle programs for children and young people are insufficient for demand, especially ...
Stephanie Smith, Stephanie Smith, Stephanie Smith, Stephen Paull, Stephen Paull, Stephen Paull, Katie M. Iwanowski, Katie M. Iwanowski, Katie M. Iwanowski, Tania Harris, Joanna C. Moullin, Monica Jane, Jordan Bill, Deborah A. Kerr, Christina M. Pollard, Glenn Pearson, Melanie Robinson, Bonnie Furzer, Bonnie Furzer, Bonnie Furzer, Natasha Bear, Ben Jackson, Ben Jackson, Robyn Mildon, Nick Sevdalis, Richard Norman, Jacqueline A. Curran, Jacqueline A. Curran, Cameron C. Grant, Sarah C. Armstrong, Sarah C. Armstrong, Yvonne C. Anderson, Yvonne C. Anderson, Yvonne C. Anderson, Yvonne C. Anderson   +34 more
doaj   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Efficient Task Replication for Fast Response Times in Parallel Computation [PDF]

, 2014
One typical use case of large-scale distributed computing in data centers is to decompose a computation job into many independent tasks and run them in parallel on different machines, sometimes known as the "embarrassingly parallel" computation. For this
Joshi, Gauri, Wang, Da, Wornell, Gregory
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