Results 81 to 90 of about 108,626 (229)

The promise and perils of asynchronous learning: how faculty, students, and administrators can collaboratively increase retention and satisfaction in the online classroom [PDF]

open access: yes, 2017
This paper explores some of the major challenges faced by faculty, students, administrators, and support staff in retaining online students, and doing so while earning high marks for the quality of each course.
Bissonette, Devan
core  

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

open access: yesMolecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon   +13 more
wiley   +1 more source

LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro

open access: yesMolecular Oncology, EarlyView.
Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix   +13 more
wiley   +1 more source

Self-Management Education Through mHealth: Review of Strategies and Structures

open access: yesJMIR mHealth and uHealth, 2018
BackgroundDespite the plethora of evidence on mHealth interventions for patient education, there is a lack of information regarding their structures and delivery strategies.
Bashi, Nazli   +4 more
doaj   +1 more source

Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition

open access: yesMolecular Oncology, EarlyView.
We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li   +10 more
wiley   +1 more source

Public Sector Climate Leadership In Boston [PDF]

open access: yes, 2015
The report discusses the important role the public sector is playing in achieving Boston's greenhouse gas emissions reduction targets. City, state, and federal agencies together own a large portion (more than 11%) of the city's building stock, and each ...

core  

Infrared laser sampling of low volumes combined with shotgun lipidomics reveals lipid markers in palatine tonsil carcinoma

open access: yesMolecular Oncology, EarlyView.
Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff   +11 more
wiley   +1 more source

Industrializing the near-earth asteroids: Speculations on human activities in space in the latter half of the 21st century [PDF]

open access: yes
The use of solar system resources for human industry can be viewed as a natural extension of the continual growth of our species' habitat. Motivations for human activities in space can be discussed in terms of five distinct areas: (1) information ...
Sercel, Joel C.
core   +1 more source

Pathways to Grow Impact: Philanthropy's Role in the Journey [PDF]

open access: yes, 2013
Since 2010, through the "Scaling What Works" initiative, GEO has fostered a conversation about scale that considers a variety of ways nonprofits are creating more value for communities and how funders are supporting their work. GEO's newest publication, "
Kathleen Enright
core  

Empowerment as a key mechanism for supporting changes in eating behaviors among disadvantaged immigrant women living with diabetes, obesity or hypertension: a realistic evaluation

open access: yesArchives of Public Health
Background While interventions aimed at improving the food habits of people living with diabetes, obesity or hypertension have been implemented and proven effective, we know little about how they produce effects.
Julia Eïd   +7 more
doaj   +1 more source

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