Results 131 to 140 of about 3,159,718 (373)
American Statistician, 2018 Statistical inference often fails to replicate. One reason is that many results may be selected for drawing inference because some threshold of a statistic like the P-value was crossed, leading to biased reported effect sizes.
Valentin Amrhein +2 more
semanticscholar +1 more source
Inhibitor of DNA binding‐1 is a key regulator of cancer cell vasculogenic mimicry
Molecular Oncology, EarlyView.Elevated expression of transcriptional regulator inhibitor of DNA binding 1 (ID1) promoted cancer cell‐mediated vasculogenic mimicry (VM) through regulation of pro‐angiogenic and pro‐cancerous genes (e.g. VE‐cadherin (CDH5), TIE2, MMP9, DKK1). Higher ID1 expression also increased metastases to the lung and the liver.
Emma J. Thompson +11 more
wiley +1 more source
Does replication groups scoring reduce false positive rate in SNP interaction discovery? [PDF]
, 2010 BACKGROUNG. Computational methods that infer single nucleotide polymorphism (SNP) interactions from phenotype data may uncover new biological mechanisms in non-Mendelian diseases. However, practical aspects of such analysis face many problems.
Curk, Tomaz +3 more
core
Intragenic origins due to short G1 phases underlie oncogene-induced DNA replication stress
Nature, 2018 Oncogene-induced DNA replication stress contributes critically to the genomic instability that is present in cancer. However, elucidating how oncogenes deregulate DNA replication has been impeded by difficulty in mapping replication initiation sites on ...
Morgane Macheret, T. Halazonetis
semanticscholar +1 more source
Molecular Oncology, EarlyView.This study used longitudinal transcriptomics and gene‐pattern classification to uncover patient‐specific mechanisms of chemotherapy resistance in breast cancer. Findings reveal preexisting drug‐tolerant states in primary tumors and diverse gene rewiring patterns across patients, converging on a few dysregulated functional modules. Despite receiving the
Maya Dadiani +14 more
wiley +1 more source
Dissection of specific binding of HIV-1 Gag to the 'packaging signal' in viral RNA
eLife, 2017 Selective packaging of HIV-1 genomic RNA (gRNA) requires the presence of a cis-acting RNA element called the ‘packaging signal’ (Ψ). However, the mechanism by which Ψ promotes selective packaging of the gRNA is not well understood.
Mauricio Comas-Garcia +5 more
doaj +1 more source
THE FRACTIONAL REPLICATION OF FACTORIAL EXPERIMENTS‐A CORRECTION [PDF]
, 1949 D. J. Finney
openalex +1 more source
Mechanisms of Oncogene-Induced Replication Stress: Jigsaw Falling into Place.
Cancer Discovery, 2018 Oncogene activation disturbs cellular processes and accommodates a complex landscape of changes in the genome that contribute to genomic instability, which accelerates mutation rates and promotes tumorigenesis.
P. Kotsantis, E. Petermann, S. Boulton
semanticscholar +1 more source
Molecular Oncology, EarlyView.B‐cell chronic lymphocytic leukemia (B‐CLL) and monoclonal B‐cell lymphocytosis (MBL) show altered proteomes and phosphoproteomes, analyzed using mass spectrometry, protein microarrays, and western blotting. Identifying 2970 proteins and 316 phosphoproteins, including 55 novel phosphopeptides, we reveal BCR and NF‐kβ/STAT3 signaling in disease ...
Paula Díez +17 more
wiley +1 more source
Testing Quantum Dynamics in Genetic Information Processing [PDF]
, 2001 Does quantum dynamics play a role in DNA replication? What type of tests would reveal that? Some statistical checks that distinguish classical and quantum dynamics in DNA replication are proposed.Comment: 4 pages, latex.
Patel, Apoorva
core +1 more source