Results 161 to 170 of about 3,159,718 (373)
Genomics‐led approach to drug testing in models of undifferentiated pleomorphic sarcoma
Molecular Oncology, EarlyView.GA text Genomic data from undifferentiated pleomorphic sarcoma patients and preclinical models were used to inform a targeted drug screen. Selected compounds were tested in 2D and 3D cultures of UPS cell lines. A combination of trametinib and infigratinib was synergistic in the majority of UPS cell lines tested, which was further confirmed in an ex ...
Piotr J. Manasterski +19 more
wiley +1 more source
HIV-1 RNA genome packaging: it’s G-rated
mBioA member of the Retroviridae, human immunodeficiency virus type 1 (HIV-1), uses the RNA genome packaged into nascent virions to transfer genetic information to its progeny.
Alice Duchon, Wei-Shau Hu
doaj +1 more source
The FDA-approved drug ivermectin inhibits the replication of SARS-CoV-2 in vitro
Antiviral Research, 2020 L. Caly +4 more
semanticscholar +1 more source
A nucleotide‐independent, pan‐RAS‐targeted DARPin elicits anti‐tumor activity in a multimodal manner
Molecular Oncology, EarlyView.We report a Designed Ankyrin Repeat Protein that binds and inhibits RAS proteins, which serve as central cell signaling hubs and are essential for the progression of many cancers. Its unique feature is that it does not discriminate between different RAS isoforms or mutations and is capable of binding to RAS in both its active (GTP‐bound) and inactive ...
Jonas N. Kapp +13 more
wiley +1 more source
Molecular Oncology, EarlyView.C–C chemokine receptor type 9 (CCR9) is an immune checkpoint in pancreatic ductal adenocarcinoma (PDAC). Novel anti‐CCR9 antibody SRB2 was evaluated in combination with cytotoxic chemotherapy in PDAC cells, patient‐derived organoids, patient‐derived xenografts, and humanized mouse models.
Hannah G. McDonald +18 more
wiley +1 more source
Essential functions of inositol hexakisphosphate (IP6) in murine leukemia virus replication
mBioWe have investigated the function of inositol hexakisphosphate (IP6) and inositol pentakisphosphate (IP5) in the replication of murine leukemia virus (MLV).
Banhi Biswas +7 more
doaj +1 more source
PROPERTIES OF A TEMPERATURE-SENSITIVE, RADIATION-SENSITIVE MUTANT OF Escherichia coli , II. DNA REPLICATION [PDF]
, 1969 Crellin Pauling, Lyla Hamm
openalex +1 more source
Philosophy of Science, 2019 This article develops a new, general account of replication (the Resampling Account of replication). I argue that a replication is an experiment that resamples the experimental components of an original experiment that are treated as random factors and that the function of replications is, narrowly, to assess the reliability of the replicated ...
openaire +2 more sources