Results 221 to 230 of about 1,158,325 (299)

The Fanconi anemia pathway repairs colibactin-induced DNA interstrand cross-links. [PDF]

Nat Commun
Altshuller M, He X, MacKrell EJ, Wernke KM, Airan Y, Wong JWH, Sellés-Baiget S, Wang TY, Chou TF, Duxin JP, Balskus EP, Herzon SB, Semlow DR.   +12 more
europepmc   +1 more source

The effect of salubrinal on the endoplasmic reticulum stress pathway in heat‐stressed spermatogonial cells in vitro

FEBS Open Bio, EarlyView.
This study investigates the protective role of salubrinal against heat‐induced endoplasmic reticulum (ER) stress in mouse spermatogenic cells (GC1 and GC2). By modulating the ER stress pathway, salubrinal alleviates cellular stress and supports spermatogenic cell survival, suggesting its potential as a therapeutic candidate for heat‐related infertility.
Suna Karadeniz Saygili, Mustafa Oztatlici, Mahmut Kemal Ozbilgin   +2 more
wiley   +1 more source

Replicon-based genome-wide CRISPR knockout screening for the identification of host factors involved in viral replication. [PDF]

Nat Commun
Cheng KW, Bhave M, Markhard AL, Peng D, Bhatt KD, Travisano KA, Medicielo JV, Anaya A, Lembirik S, Njoya L, Anantpadma M, Kuhn JH, Puschnik AS, Kistler AL.   +13 more
europepmc   +1 more source

Evaluation of in vitro toxicity of common phytochemicals included in weight loss supplements using 1H NMR spectroscopy

FEBS Open Bio, EarlyView.
We investigated the toxicity of 12 active compounds commonly found in herbal weight loss supplements (WLS) using human liver and colon cell models. Epigallocatechin‐3‐gallate was the only compound showing significant toxicity. Metabolic profiling revealed protein degradation, disrupted energy and lipid metabolism suggesting that the inclusion of EGCG ...
Emily C. Davies, Garth L. Maker, Ian F. Musgrave, Samantha Lodge   +3 more
wiley   +1 more source

Autophagy and ubiquitination in important swine viral infections: Host defense and viral antagonism. [PDF]

Virulence
He Z, Liu M, Xie Q, Lu H, Guo C.
europepmc   +1 more source

KLK7 overexpression promotes an aggressive phenotype and facilitates peritoneal dissemination in colorectal cancer cells

FEBS Open Bio, EarlyView.
KLK7, a tissue kallikrein‐related peptidase, is elevated in advanced colorectal cancer and associated with shorter survival. High KLK7 levels in ascites correlate with peritoneal metastasis. In mice, KLK7 overexpression increases metastasis. In vitro, KLK7 enhances cancer cell proliferation, migration, adhesion, and spheroid formation, driving ...
Yosr Z. Haffani, Tobias Dreyer, Meriem Naim, Rea Lo Dico, Natalia A. Ignatenko, Viktor Magdolen, Dalila Darmoul   +6 more
wiley   +1 more source

The need for speed: drivers and consequences of accelerated replication forks. [PDF]

Commun Biol
Lukáč D, Chromá K, Moudrý P.
europepmc   +1 more source

Cytology of DNA Replication Reveals Dynamic Plasticity of Large-Scale Chromatin Fibers

, 2016
Xiang Deng, Oxana A. Zhironkina, Varvara D. Cherepanynets, Olga Strelkova, Igor I. Kireev, Andrew S. Belmont   +5 more
openalex   +2 more sources

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

FEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point, Wafaa Achache, Janïs Laudouze, Eliana Sepulveda Ramos, Mickaël Maziero, Céline Crauste, Stéphane Canaan, Pierre Santucci   +7 more
wiley   +1 more source

Alkaline Bromodeoxyuridine (BrdU) Comet Assay to Detect Replication-Associated DNA Damage. [PDF]

Curr Protoc
Ribeiro DL, Londero JEL, Martins DJ, Menck CFM.   +3 more
europepmc   +1 more source