Results 111 to 120 of about 1,779,695 (298)

The replication crisis has led to positive structural, procedural, and community changes. [PDF]

Commun Psychol, 2023
Korbmacher M, Azevedo F, Pennington CR, Hartmann H, Pownall M, Schmidt K, Elsherif M, Breznau N, Robertson O, Kalandadze T, Yu S, Baker BJ, O'Mahony A, Olsnes JØ, Shaw JJ, Gjoneska B, Yamada Y, Röer JP, Murphy J, Alzahawi S, Grinschgl S, Oliveira CM, Wingen T, Yeung SK, Liu M, König LM, Albayrak-Aydemir N, Lecuona O, Micheli L, Evans T.   +29 more
europepmc   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

A Systematic Review on the Evolution of Power Analysis Practices in Psychological Research

Psychologica Belgica
Performing hypothesis tests with adequate statistical power is indispensable for psychological research. In response to several large-scale replication projects following the replication crisis, concerns about the root causes of this crisis – such as ...
Lara Vankelecom, Ole Schacht, Nathan Laroy, Tom Loeys, Beatrijs Moerkerke   +4 more
doaj   +1 more source

Is the replication crisis a base-rate fallacy? [PDF]

Theor Med Bioeth, 2021
Autzen B.
europepmc   +1 more source

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

Molecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang, Hyung Seok Kim, Geum Ok Baek, Moon Gyeong Yoon, Su In Lee, Jee‐Yeong Jeong, Ji Eun Han, Soon Sun Kim, Jae Youn Cheong, Jung Woo Eun   +9 more
wiley   +1 more source

The Replication Crisis in Psychology

International Review of Theoretical Psychologies
The replication crisis in psychology is often framed as a methodological failure—an issue of flawed statistical practices, publication bias, and poor experimental design. While these factors undoubtedly play a role, this article argues that the replication crisis is much more than a methodological problem.
openaire   +1 more source

Translating whole‐genome doubling into precision medicine in cancer

Molecular Oncology, EarlyView.
Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley   +1 more source

Rape Crisis Centre July '97 to June '98 statistics and financial summary.

, 1998
I have audited the financial statements above and opposite in accordance with Auditing Standards. In my opinion, the financial statements give a true and fair view of the statement of the company's affairs at 31 5t December 1997, and of its results ...
Rape Crisis Centre.
core  

Central Asia: Crisis Conditions in Three States

, 2000
This is an ICG Asia Report titled Central Asia: Crisis Conditions in Three States: It analyzes the political and social crises facing three Central Asian countries, examining the factors contributing to instability, such as authoritarian governance ...
International Crisis Group
core   +1 more source

How failure to falsify in high-volume science contributes to the replication crisis. [PDF]

Elife, 2022
Rajtmajer SM, Errington TM, Hillary FG.
europepmc   +1 more source