Results 91 to 100 of about 1,779,695 (298)
KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer
Molecular Oncology, EarlyView.Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan +16 more
wiley +1 more source
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
Financial Crisis Inquiry Commission
, 2011 This website contains the research and final report for the Financial Crisis Inquiry Commission looking at the causes of the economic ...
United States. Financial Crisis Inquiry Commission.
core
Passive investing before and after the crisis: investors' views on exchange-traded funds and competing index products [PDF]
, 2011 Investment in exchange-traded funds (ETFs) has been remarkably robust in the course of the recent financial crisis. This paper analyzes investors' perceptions of ETFs and other indexing products by comparing the answers to two surveys of ETF users ...
Goltz, F., Schröder, David
core
Publication bias is bad for science if not necessarily scientists
Royal Society Open ScienceIt might seem obvious that the scientific process should not be biased. We strive for reliable inference, and systematically skewing the results of inquiry apparently conflicts with this.
Remco Heesen, Liam Kofi Bright
doaj +1 more source
When Null Hypothesis Significance Testing Is Unsuitable for Research: A Reassessment
Frontiers in Human Neuroscience, 2017 Null hypothesis significance testing (NHST) has several shortcomings that are likely contributing factors behind the widely debated replication crisis of (cognitive) neuroscience, psychology, and biomedical science in general.
Denes Szucs, John P. A. Ioannidis
doaj +1 more source
Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source
The Music of Power: a direct replication study [PDF]
, 2022 openIn the last years psychology, alongside many other sciences, has faced a phenomenon known as the replicability crisis. Publications, which formed the theoretical bases for entire generations of psychologists, have undergone replication efforts, in ...
BURATTO, SILVIA
core
Revisiting the Replication Crisis and the Untrustworthiness of Empirical Evidence
StatsThe current replication crisis relating to the non-replicability and the untrustworthiness of published empirical evidence is often viewed through the lens of the Positive Predictive Value (PPV) in the context of the Medical Diagnostic Screening (MDS ...
Aris Spanos
doaj +1 more source