Results 71 to 80 of about 1,779,695 (298)
Psychologica Belgica, 2019 A crescendo of incidents have raised concerns about whether scientific practices in psychology may be suboptimal, sometimes leading to the publication, dissemination, and application of unreliable or misinterpreted findings.
Lee Jussim +3 more
doaj +1 more source
Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry
FEBS Letters, EarlyView.EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri +5 more
wiley +1 more source
Critical EducationThe epistemological commitments of any scientific discipline are reflected in the changing beliefs and identities of its students. Challenges to psychology’s scientific legitimacy presented by the recent replication crisis have underscored the need for ...
James Y. Yuan, Romin W. Tafarodi
doaj +1 more source
Psychology’s Replication Crisis and Clinical Psychological Science
Annual Review of Clinical Psychology, 2018 Despite increasing interest in issues of replicability, open science, research transparency, and improving methods and practices in psychological science, the clinical psychology community has been slow to engage. This has been slowly shifting, and the authors of the present article hope to facilitate this emerging dialogue.
Jennifer L Tackett +3 more
openaire +3 more sources
Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding
FEBS Letters, EarlyView.In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança +2 more
wiley +1 more source
Mathematical modelling of whole chromosome replication [PDF]
, 2010 All chromosomes must be completely replicated prior to cell division, a requirement that demands the activation of a sufficient number of appropriately distributed DNA replication origins.
de Moura, Alessandro P.S. +4 more
core +1 more source
Behavioral Sciences, 2017 Virtually everybody would agree that life satisfaction is of immense importance in everyday life. Thus, it is not surprising that a considerable amount of research using many different methodological approaches has investigated what the best predictors ...
Bernd Lachmann +10 more
doaj +1 more source
Calenda, 2020 The results of good science are supposed to be true everywhere and at any time: replicability is traditionally considered a ground of the epistemic authority of modern science. However, in somecases (especially in biomedical, social and psychological studies), important published scientific findings have failed to replicate.
openaire +1 more source
‘Guide and Prejudice’— How Argonautes recognize targets across domains of life
FEBS Letters, EarlyView.Argonaute proteins use short nucleic‐acid guides to locate and regulate specific targets across all domains of life. Despite striking diversity—from human gene silencing to bacterial immune defence—all Argonautes share a conserved three‐stage recognition logic: guide‐directed sampling, progressive target pairing with a conformational checkpoint and ...
Jack P. K. Bravo
wiley +1 more source