Results 61 to 70 of about 1,779,695 (298)
FEBS Letters, EarlyView.Cancer progression is regulated by the dynamic matrix code of the tumor microenvironment, which influences cellular behavior and disease development. Importantly, matrix remodeling in three‐dimensional cancer models more accurately reflects in vivo conditions compared to conventional two‐dimensional systems.
Sylvia Mangani +3 more
wiley +1 more source
Replication factory activation can be decoupled from the replication timing program by modulating Cdk levels [PDF]
, 2010 In the metazoan replication timing program, clusters of replication origins located in different subchromosomal domains fire at different times during S phase. We have used Xenopus laevis egg extracts to drive an accelerated replication timing program in
Blow, J. Julian; id_orcid +6 more
core +1 more source
European Journal of Psychotraumatology, 2019 Adopting Registered Reports is an important step for the European Journal of Psychotraumatology to promote open science practices in the field of psychotrauma research. However, adopting these practices requires us as individual researchers to change our
Ineke Wessel, Helen Niemeyer
doaj +1 more source
A survey on how preregistration affects the research workflow: better science but more work
Royal Society Open Science, 2022 The preregistration of research protocols and analysis plans is a main reform innovation to counteract confirmation bias in the social and behavioural sciences.
Alexandra Sarafoglou +4 more
doaj +1 more source
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
The Understanding on How to Determine Sample Size in Psychological Science: Data and Simulation
Jurnal Psikologi, 2019 The lack of knowledge on how to determine sample sizes in experiments is arguably one of the main reasons underlying the replication crisis in psychological science. A survey distributed among Indonesian students and researchers concerning 1) familiarity
Wisnu Wiradhany +3 more
doaj +1 more source
Metascience could rescue the ‘replication crisis’ [PDF]
Nature, 2014 Independent replication of studies before publication may reveal sources of unreliable results, says Jonathan W. Schooler.
openaire +2 more sources
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
Epigenetic reprogramming of lineage switching in cancer
FEBS Letters, EarlyView.Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı +4 more
wiley +1 more source
Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network
FEBS Letters, EarlyView.Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley +1 more source