Results 51 to 60 of about 76,259 (304)
RuvAB Acts at Arrested Replication Forks [PDF]
Cell, 1998 Replication arrest leads to the occurrence of DNA double-stranded breaks (DSB). We studied the mechanism of DSB formation by direct measure of the amount of in vivo linear DNA in Escherichia coli cells that lack the RecBCD recombination complex and by genetic means.
Seigneur, Marie +3 more
openaire +3 more sources
Rif1 inhibits replication fork progression and controls DNA copy number in Drosophila
eLife, 2018 Control of DNA copy number is essential to maintain genome stability and ensure proper cell and tissue function. In Drosophila polyploid cells, the SNF2-domain-containing SUUR protein inhibits replication fork progression within specific regions of the ...
Alexander Munden +5 more
doaj +1 more source
Proficient replication of the yeast genome by a viral DNA polymerase [PDF]
, 2016 DNA replication in eukaryotic cells requires minimally three B-family DNA polymerases: Pol α, Pol δ, and Pol ϵ. Pol δ replicates and matures Okazaki fragments on the lagging strand of the replication fork.
Burgers, Peter M +2 more
core +2 more sources
Naked Replication Forks Break apRPArt [PDF]
Cell, 2013 Stalled replication forks occasionally collapse, leading to potentially catastrophic DNA double-strand breaks. Now, Toledo et al. (2013) reveal that fork breakage occurs when the pool of the single-strand DNA-binding protein RPA becomes exhausted.
Fernandez-Capetillo O, Nussenzweig A
openaire +2 more sources
ATAD5 promotes replication restart by regulating RAD51 and PCNA in response to replication stress [PDF]
, 2019 Maintaining stability of replication forks is important for genomic integrity. However, it is not clear how replisome proteins contribute to fork stability under replication stress. Here, we report that ATAD5, a PCNA unloader, plays multiple functions at
A Ciccia +42 more
core +2 more sources
FBH1 Catalyzes Regression of Stalled Replication Forks
Cell Reports, 2015 DNA replication fork perturbation is a major challenge to the maintenance of genome integrity. It has been suggested that processing of stalled forks might involve fork regression, in which the fork reverses and the two nascent DNA strands anneal.
Kasper Fugger +11 more
doaj +1 more source
FORK-seq: replication landscape of the Saccharomyces cerevisiae genome by nanopore sequencing
Genome Biology, 2020 Genome replication mapping methods profile cell populations, masking cell-to-cell heterogeneity. Here, we describe FORK-seq, a nanopore sequencing method to map replication of single DNA molecules at 200-nucleotide resolution.
Magali Hennion +12 more
doaj +1 more source
Interplay between chromosomal architecture and termination of DNA replication in bacteria
Frontiers in Microbiology, 2023 Faithful transmission of the genome from one generation to the next is key to life in all cellular organisms. In the majority of bacteria, the genome is comprised of a single circular chromosome that is normally replicated from a single origin, though ...
Daniel J. Goodall +3 more
doaj +1 more source
PLoS ONE, 2010 Multiple genome maintenance processes are coordinated at the replication fork to preserve genomic integrity. How eukaryotic cells accomplish such a coordination is unknown.
Jordan B Rapp +7 more
doaj +1 more source
Recovery of arrested replication forks by homologous recombination is error-prone. [PDF]
PLoS Genetics, 2012 Homologous recombination is a universal mechanism that allows repair of DNA and provides support for DNA replication. Homologous recombination is therefore a major pathway that suppresses non-homology-mediated genome instability.
Ismail Iraqui +6 more
doaj +1 more source