Results 51 to 60 of about 508,345 (256)

Checkpoint-dependent and -independent roles of Swi3 in replication fork recovery and sister chromatid cohesion in fission yeast.

PLoS ONE, 2010
Multiple genome maintenance processes are coordinated at the replication fork to preserve genomic integrity. How eukaryotic cells accomplish such a coordination is unknown.
Jordan B Rapp, Chiaki Noguchi, Mukund M Das, Lisa K Wong, Alison B Ansbach, Allyson M Holmes, Benoit Arcangioli, Eishi Noguchi   +7 more
doaj   +1 more source

A new role for Rrm3 in repair of replication-born DNA breakage by sister chromatid recombination. [PDF]

PLoS Genetics, 2017
Replication forks stall at different DNA obstacles such as those originated by transcription. Fork stalling can lead to DNA double-strand breaks (DSBs) that will be preferentially repaired by homologous recombination when the sister chromatid is ...
Sandra Muñoz-Galván, María García-Rubio, Pedro Ortega, Jose F Ruiz, Sonia Jimeno, Benjamin Pardo, Belén Gómez-González, Andrés Aguilera   +7 more
doaj   +1 more source

RNA‐related functions of BRCA2 in transcription, replication, and genome stability

FEBS Letters, EarlyView.
Beyond its role in homologous recombination, BRCA2 regulates R‐loop homeostasis, DNA–RNA hybrid resolution, RNA polymerase II dynamics, and transcriptional activation. Disruption of any of these functions can contribute to genome instability, inflammatory signaling, and tumorigenesis. BRCA2 is a central tumor suppressor protein best known for its roles
Lucia Alvaro‐Aranda, Sreerama Chaitanya Sridhara, Aura Carreira   +2 more
wiley   +1 more source

Embryonic stem cells maintain high origin activity and slow forks to coordinate replication with cell cycle progression

EMBO Reports
Embryonic stem (ES) cells are pluripotent stem cells that can produce all cell types of an organism. ES cells proliferate rapidly and are thought to experience high levels of intrinsic replication stress.
Kiminori Kurashima, Yasunao Kamikawa, Tomomi Tsubouchi   +2 more
doaj   +1 more source

ATP Binding to Rad5 Initiates Replication Fork Reversal by Inducing the Unwinding of the Leading Arm and the Formation of the Holliday Junction

Cell Reports, 2018
Summary: Replication fork reversal is one of the major pathways for reactivating stalled DNA replication. Many enzymes with replication fork reversal activity have DNA-unwinding activity as well, but none of the fork reversal enzymes in the SWI/SNF ...
Soochul Shin, Kwangbeom Hyun, Jaehoon Kim, Sungchul Hohng   +3 more
doaj   +1 more source

The ubiquitin system in normal and infected germinal center B cells

FEBS Letters, EarlyView.
The ubiquitin system plays a central role in germinal center (GC) B cells, influencing differentiation to long‐lived memory B cells. Oncogenic gammaherpesviruses gain access to memory B cells by establishing latency in GC B cells. Mapping ubiquitin mechanisms in normal and infected GC B cells will define specific molecular circuits in B cells germane ...
Destiny Davis, Lesly Mejia, Emily K Moser   +2 more
wiley   +1 more source

High-Resolution Replication Profiles Define the Stochastic Nature of Genome Replication Initiation and Termination [PDF]

, 2013
Copyright © 2013 The Authors. Published by Elsevier Inc.
Nieduszynski, Conrad A, Tanaka, Tomoyuki U.; id_orcid, de Moura, Alessandro P. S., Tanaka, Tomoyuki U., Saner, Nazan, de Moura, Alessandro P S, Nieduszynski, Conrad A., deMoura, Alessandro P. S., Hawkins, Michelle, Renata Retkute, Müller, Carolin A, Tanaka, Tomoyuki U, Alessandro P.S. de Moura, Tomoyuki U. Tanaka, Michelle Hawkins, M�ller, Carolin A., Müller, Carolin A., de Moura, Alessandro P.S., Carolin A. Müller, Nazan Saner, Retkute, Renata, Conrad A. Nieduszynski   +21 more
core   +1 more source

Membrane composition and thermodynamic identity as boundaries of life for synthetic cell research

FEBS Letters, EarlyView.
What makes a cell a cell? The boundary of a living cell is not just a wall. Read as a Markov blanket, the membrane separates internal from external states, generating identity and non‐equilibrium order. Can this identity be rebuilt from scratch in a synthetic cell?
Caterina Presutti, Bert Poolman
wiley   +1 more source

Identification of replication fork-associated proteins in Drosophila embryos and cultured cells using iPOND coupled to quantitative mass spectrometry

Scientific Reports, 2022
Replication of the eukaryotic genome requires the formation of thousands of replication forks that must work in concert to accurately replicate the genetic and epigenetic information.
Alexander Munden, Madison T. Wright, Dongsheng Han, Reyhaneh Tirgar, Lars Plate, Jared T. Nordman   +5 more
doaj   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source