Results 31 to 40 of about 76,259 (304)
Inter-Fork Strand Annealing causes genomic deletions during the termination of DNA replication
eLife, 2017 Problems that arise during DNA replication can drive genomic alterations that are instrumental in the development of cancers and many human genetic disorders. Replication fork barriers are a commonly encountered problem, which can cause fork collapse and
Carl A Morrow +6 more
doaj +1 more source
Dna2 Helicase/Nuclease Causes Replicative Fork Stalling and Double-strand Breaks in the Ribosomal DNA of Saccharomyces cerevisiae [PDF]
, 2003 We have proposed that faulty processing of arrested replication forks leads to increases in recombination and chromosome instability in Saccharomyces cerevisiae and contributes to the shortened lifespan of dna2 mutants. Now we use the ribosomal DNA locus,
Budd, Martin +3 more
core +2 more sources
Nature Communications, 2023 Homologous recombination factors play a crucial role in protecting nascent DNA during DNA replication, but the role of chromatin in this process is largely unknown.
Nagham Ghaddar +5 more
doaj +1 more source
When replication forks stop [PDF]
Molecular Microbiology, 1994 SummaryDNA synthesis is an accurate and very processive phenomenon, yet chromosome replication does not proceed at a constant rate and progression of the replication fork can be impeded. Several structural and functional features of the template can modulate the rate of progress of the replication fork.
Bierne, Hélène, Michel, B.
openaire +3 more sources
Opposing Roles of FANCJ and HLTF Protect Forks and Restrain Replication during Stress
Cell Reports, 2018 Summary: The DNA helicase FANCJ is mutated in hereditary breast and ovarian cancer and Fanconi anemia (FA). Nevertheless, how loss of FANCJ translates to disease pathogenesis remains unclear.
Min Peng +10 more
doaj +1 more source
Translesion synthesis in mammalian cells [PDF]
, 2006 DNA damage blocks the progression of the replication fork. In order to circumvent the damaged bases, cells employ specialized low stringency DNA polymerases, which are able to carry out translesion synthesis (TLS) past different types of damage. The five
Alan R. Lehmann +35 more
core +2 more sources
Replication termination without a replication fork trap [PDF]
Scientific Reports, 2019 Abstract Bacterial chromosomes harbour a unique origin of bidirectional replication, oriC . They are almost always circular, with replication terminating in a region diametrically opposite to oriC , the terminus. The
Galli, Elisa +6 more
openaire +3 more sources
Epigenetics & Chromatin, 2019 Background Histone acetylation plays an important role in DNA replication and repair because replicating chromatin is subject to dynamic changes in its structures. However, its precise mechanism remains elusive.
Chiaki Noguchi +7 more
doaj +1 more source
SDE2 integrates into the TIMELESS-TIPIN complex to protect stalled replication forks
Nature Communications, 2020 The fork protection complex (FPC), including the proteins TIMELESS and TIPIN, stabilizes the replisome to ensure unperturbed fork progression during DNA replication.
Julie Rageul +10 more
doaj +1 more source
Mechanisms and regulation of replication fork reversal. [PDF]
DNA Repair (Amst)DNA replication is remarkably accurate with estimates of only a handful of mutations per human genome per cell division cycle. Replication stress caused by DNA lesions, transcription-replication conflicts, and other obstacles to the replication machinery must be efficiently overcome in ways that minimize errors and maximize completion of DNA synthesis.
Adolph MB, Cortez D.
europepmc +3 more sources