Differential Requirements for MCM Proteins in DNA Replication in Drosophila S2 Cells. [PDF]
, 2007 BACKGROUND: The MCM2-7 proteins are crucial components of the pre replication complex (preRC) in eukaryotes. Since they are significantly more abundant than other preRC components, we were interested in determining whether the entire cellular content was
Reina Hashimoto +30 more
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Epigenetics & Chromatin, 2019 Background Histone acetylation plays an important role in DNA replication and repair because replicating chromatin is subject to dynamic changes in its structures. However, its precise mechanism remains elusive.
Chiaki Noguchi +7 more
doaj +1 more source
Cellular location and activity of Escherichia coli RecG proteins shed light on the function of its structurally unresolved C-terminus [PDF]
, 2014 RecG is a DNA translocase encoded by most species of bacteria. The Escherichia coli protein targets branched DNA substrates and drives the unwinding and rewinding of DNA strands.
Briggs, Geoffrey S. +13 more
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SDE2 integrates into the TIMELESS-TIPIN complex to protect stalled replication forks
Nature Communications, 2020 The fork protection complex (FPC), including the proteins TIMELESS and TIPIN, stabilizes the replisome to ensure unperturbed fork progression during DNA replication.
Julie Rageul +10 more
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Localization of an accessory helicase at the replisome is critical in sustaining efficient genome duplication [PDF]
, 2010 © The Author(s) 2010. Published by Oxford University PressGenome duplication requires accessory helicases to displace proteins ahead of advancing replication forks.
Lloyd, RG +11 more
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Topoisomerase II Is Crucial for Fork Convergence during Vertebrate Replication Termination
Cell Reports, 2019 Summary: Termination of DNA replication occurs when two replication forks converge upon the same stretch of DNA. Resolution of topological stress by topoisomerases is crucial for fork convergence in bacteria and viruses, but it is unclear whether similar
Darren R. Heintzman +4 more
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The contribution of dormant origins to genome stability:from cell biology to human genetics [PDF]
, 2014 The ability of a eukaryotic cell to precisely and accurately replicate its DNA is crucial to maintain genome stability. Here we describe our current understanding of the process by which origins are licensed for DNA replication and review recent work ...
Blow, J. Julian; id_orcid +3 more
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RAD51 is a druggable target that sustains replication fork progression upon DNA replication stress.
PLoS ONE, 2022 Solving the problems that replication forks encounter when synthesizing DNA is essential to prevent genomic instability. Besides their role in DNA repair in the G2 phase, several homologous recombination proteins, specifically RAD51, have prominent roles
Sonia Feu +5 more
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MCM-GINS and MCM-MCM interactions in vivo visualised by bimolecular fluorescence complementation in fission yeast [PDF]
, 2009 Background: Each of the three individual components of the CMG complex (Cdc45, MCM and GINS) is essential for chromosomal DNA replication in eukaryotic cells, both for the initiation of replication at origins and also for normal replication fork ...
Gökhan Akman +5 more
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A game of substrates: replication fork remodeling and its roles in genome stability and chemo-resistance [PDF]
, 2017 During the hours that human cells spend in the DNA synthesis (S) phase of the cell cycle, they may encounter adversities such as DNA damage or shortage of nucleotides.
Julia Sidorova
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