Results 11 to 20 of about 508,345 (256)

DNA replication is required for the checkpoint response to damaged DNA in Xenopus egg extracts. [PDF]

, 2002
Alkylating agents, such as methyl methanesulfonate (MMS), damage DNA and activate the DNA damage checkpoint. Although many of the checkpoint proteins that transduce damage signals have been identified and characterized, the mechanism that senses the ...
Lindsay, Howard D., Stokes, Matthew P., Van Hatten, Ruth, Howard D. Lindsay (4252681), Howard D. Lindsay, W. Matthew Michael, Ruth Van Hatten (16043837), W. Matthew Michael (3211092), Ruth Van Hatten, Matthew P. Stokes, Matthew P. Stokes (9707794), Michael, W. Matthew   +11 more
core   +5 more sources

Nuclear actin polymerization rapidly mediates replication fork remodeling upon stress by limiting PrimPol activity

Nature Communications, 2023
Cells rapidly respond to replication stress actively slowing fork progression and inducing fork reversal. How replication fork plasticity is achieved in the context of nuclear organization is currently unknown.
Maria Dilia Palumbieri, Chiara Merigliano, Daniel González-Acosta, Danina Kuster, Jana Krietsch, Henriette Stoy, Thomas von Känel, Svenja Ulferts, Bettina Welter, Joël Frey, Cyril Doerdelmann, Andrea Sanchi, Robert Grosse, Irene Chiolo, Massimo Lopes   +14 more
doaj   +1 more source

ATR-Mediated Global Fork Slowing and Reversal Assist Fork Traverse and Prevent Chromosomal Breakage at DNA Interstrand Cross-Links

Cell Reports, 2018
Summary: Interstrand cross-links (ICLs) are toxic DNA lesions interfering with DNA metabolism that are induced by widely used anticancer drugs. They have long been considered absolute roadblocks for replication forks, implicating complex DNA repair ...
Karun Mutreja, Jana Krietsch, Jeannine Hess, Sebastian Ursich, Matteo Berti, Fabienne K. Roessler, Ralph Zellweger, Malay Patra, Gilles Gasser, Massimo Lopes   +9 more
doaj   +1 more source

The DNA helicase Pfh1 promotes fork merging at replication termination sites to ensure genome stability [PDF]

, 2012
Bidirectionally moving DNA replication forks merge at termination sites composed of accidental or programmed DNA-protein barriers. If merging fails, then regions of unreplicated DNA can result in the breakage of DNA during mitosis, which in turn can give
Steinacher, R., Whitby, M. C., Whitby, Matthew C., Steinacher, R, Dalgaard, JZ, Osman, F., Lorenz, Alexander, Whitby, Matthew, Steinacher, Roland, Osman, F, Lorenz, A, Whitby, MC, Lorenz, A., Osman, Fekret, Dalgaard, Jacob Z.   +14 more
core   +1 more source

Ultrafine anaphase bridges, broken DNA and illegitimate recombination induced by a replication fork barrier [PDF]

, 2011
Most DNA double-strand breaks (DSBs) in S- and G2-phase cells are repaired accurately by Rad51-dependent sister chromatid recombination. However, a minority give rise to gross chromosome rearrangements (GCRs), which can result in disease/death.
Ledesma, Jennifer, Whitby, Matthew C., Castagnetti, S, Sofueva, Sevil, Alexander Lorenz, Steinacher, R, Fekret Osman, Lorenz, Alexander, Sofueva, S, Ledesma, J, Castagnetti, Stefania, Whitby, Matthew, Steinacher, Roland, Sevil Sofueva, Stefania Castagnetti, Osman, F, Lorenz, A, Matthew C. Whitby, Whitby, MC, Osman, Fekret, Roland Steinacher, Jennifer Ledesma   +21 more
core   +1 more source

Recombination occurs within minutes of replication blockage by RTS1 producing restarted forks that are prone to collapse

eLife, 2015
The completion of genome duplication during the cell cycle is threatened by the presence of replication fork barriers (RFBs). Following collision with a RFB, replication proteins can dissociate from the stalled fork (fork collapse) rendering it incapable
Michael O Nguyen, Manisha Jalan, Carl A Morrow, Fekret Osman, Matthew C Whitby   +4 more
doaj   +1 more source

Replication fork collisions cause pathological chromosomal amplification in cells lacking RecG DNA translocase [PDF]

, 2009
This is an open access article, shared under a Creative Commons licence. Copyright © 2009 The Authors.Duplication and transmission of chromosomes require precise control of chromosome replication and segregation.
Lloyd, RG, Robert G. Lloyd, Christian J. Rudolph, Amy L. Upton, Upton, AL   +4 more
core   +1 more source

Avoiding chromosome pathology when replication forks collide [PDF]

, 2013
This is the author's accepted manuscript. The final published article is available from the link below. Copyright @ 2013 Macmillan Publishers Limited.Chromosome duplication normally initiates through the assembly of replication fork complexes at defined ...
Lloyd, RG, Stockum, A, Nieduszynski, CA, Upton, AL   +3 more
core   +1 more source

Replisome Dynamics and Their Functional Relevance upon DNA Damage through the PCNA Interactome

Cell Reports, 2018
Summary: Eukaryotic cells use copious measures to ensure accurate duplication of the genome. Various genotoxic agents pose threats to the ongoing replication fork that, if not efficiently dealt with, can result in replication fork collapse. It is unknown
Mrinal Srivastava, Zhen Chen, Huimin Zhang, Mengfan Tang, Chao Wang, Sung Yun Jung, Junjie Chen   +6 more
doaj   +1 more source

Top2 and Sgs1-Top3 Act Redundantly to Ensure rDNA Replication Termination. [PDF]

PLoS Genetics, 2015
Faithful DNA replication with correct termination is essential for genome stability and transmission of genetic information. Here we have investigated the potential roles of Topoisomerase II (Top2) and the RecQ helicase Sgs1 during late stages of ...
Kamilla Mundbjerg, Signe W Jørgensen, Jacob Fredsøe, Ida Nielsen, Jakob Madsen Pedersen, Iben Bach Bentsen, Michael Lisby, Lotte Bjergbaek, Anni H Andersen   +8 more
doaj   +1 more source