Results 11 to 20 of about 76,259 (304)
Replication-Fork Dynamics [PDF]
Cold Spring Harbor Perspectives in Biology, 2013 The proliferation of all organisms depends on the coordination of enzymatic events within large multiprotein replisomes that duplicate chromosomes. Whereas the structure and function of many core replisome components have been clarified, the timing and order of molecular events during replication remains obscure.
Duderstadt, Karl E +3 more
openaire +4 more sources
Replication Fork Reversal and Protection [PDF]
Frontiers in Cell and Developmental Biology, 2021 During genome replication, replication forks often encounter obstacles that impede their progression. Arrested forks are unstable structures that can give rise to collapse and rearrange if they are not properly processed and restarted. Replication fork reversal is a critical protective mechanism in higher eukaryotic cells in response to replication ...
Shan Qiu +6 more
openaire +3 more sources
Separase prevents genomic instability by controlling replication fork speed [PDF]
, 2016 Proper chromosome segregation is crucial for preserving genomic integrity, and errors in this process cause chromosome mis-segregation, which may contribute to cancer development.
Cucco, Francesco +11 more
core +6 more sources
Nature Communications, 2023 Cells rapidly respond to replication stress actively slowing fork progression and inducing fork reversal. How replication fork plasticity is achieved in the context of nuclear organization is currently unknown.
Maria Dilia Palumbieri +14 more
doaj +1 more source
PCNA, the Maestro of the Replication Fork [PDF]
Cell, 2007 Inheritance requires genome duplication, reproduction of chromatin and its epigenetic information, mechanisms to ensure genome integrity, and faithful transmission of the information to progeny. Proliferating cell nuclear antigen (PCNA)-a cofactor of DNA polymerases that encircles DNA-orchestrates several of these functions by recruiting crucial ...
Moldovan, G., Pfander, B., Jentsch, S.
openaire +3 more sources
Cell Reports, 2018 Summary: Interstrand cross-links (ICLs) are toxic DNA lesions interfering with DNA metabolism that are induced by widely used anticancer drugs. They have long been considered absolute roadblocks for replication forks, implicating complex DNA repair ...
Karun Mutreja +9 more
doaj +1 more source
Fork rotation and DNA precatenation are restricted during DNA replication to prevent chromosomal instability [PDF]
, 2015 Faithful genome duplication and inheritance require the complete resolution of all intertwines within the parental DNA duplex. This is achieved by topoisomerase action ahead of the replication fork or by fork rotation and subsequent resolution of the DNA
Anna L. Chambers +5 more
core +3 more sources
Avoiding chromosome pathology when replication forks collide [PDF]
, 2013 This is the author's accepted manuscript. The final published article is available from the link below. Copyright @ 2013 Macmillan Publishers Limited.Chromosome duplication normally initiates through the assembly of replication fork complexes at defined ...
Lloyd, RG +3 more
core +1 more source
Nucleosome positioning at the replication fork [PDF]
The EMBO Journal, 2001 In order to determine the time required for nucleosomes assembled on the daughter strands of replication forks to assume favoured positions with respect to DNA sequence, psoralen cross-linked replication intermediates purified from preparative two-dimensional agarose gels were analysed by exonuclease digestion or primer extension.
Lucchini R, Wellinger RE, Sogo JM
openaire +3 more sources
eLife, 2015 The completion of genome duplication during the cell cycle is threatened by the presence of replication fork barriers (RFBs). Following collision with a RFB, replication proteins can dissociate from the stalled fork (fork collapse) rendering it incapable
Michael O Nguyen +4 more
doaj +1 more source