Results 1 to 10 of about 36,670 (261)

H2BK120ub and its reader RNF169 sequentially regulate replication fork remodeling and stability [PDF]

The EMBO Journal
Ubiquitination of the C-terminus of histone H2B (H2BK120ub) is a key histone modification with functions in a wide array of DNA-related processes, best characterized in gene transcription and repair.
Filip D Duzanic, Vaishnavi Mohana-Natarajan, Samuele Fisicaro, Collin Bakker, Moses Aouami, Gabriel Amaral, Massimo Lopes, Nitika Taneja, Lorenza Penengo   +8 more
doaj   +2 more sources

Mechanisms and regulation of replication fork reversal. [PDF]

DNA Repair (Amst)
DNA replication is remarkably accurate with estimates of only a handful of mutations per human genome per cell division cycle. Replication stress caused by DNA lesions, transcription-replication conflicts, and other obstacles to the replication machinery must be efficiently overcome in ways that minimize errors and maximize completion of DNA synthesis.
Adolph MB, Cortez D.
europepmc   +3 more sources

An additional replication origin causes cell cycle specific DNA replication fork speed [PDF]

Frontiers in Microbiology
Replication fork speed (RFS) in Escherichia coli has long been considered constant throughout the replication and cell cycles. In wild-type cells, the circular chromosome is duplicated bidirectionally from oriC, yielding two replication forks that ...
Ole Skovgaard
doaj   +2 more sources

Automated mapping of DNA replication fork progression in human cells with ForkML [PDF]

Nature Communications
Current approaches to mapping fork progression in the human genome suffer from drastically low throughput. Here, we introduce ForkML, a nanopore sequencing-based method automatically positioning thousands of individual fork velocities by tracking BrdU ...
Victoria Rojat, Diletta Ciardo, Alan Tourancheau, Florence Proux, Etienne Jean, Jean-Michel Arbona, Benjamin Audit, Gael A. Millot, Frédéric Bonhomme, Paola B. Arimondo, Olivier Hyrien, Benoît Le Tallec   +11 more
doaj   +2 more sources

Replication-Fork Dynamics [PDF]

Cold Spring Harbor Perspectives in Biology, 2013
The proliferation of all organisms depends on the coordination of enzymatic events within large multiprotein replisomes that duplicate chromosomes. Whereas the structure and function of many core replisome components have been clarified, the timing and order of molecular events during replication remains obscure.
Duderstadt, Karl E, Reyes-Lamothe, Rodrigo, van Oijen, Antoine M, Sherratt, David J   +3 more
openaire   +4 more sources

Gene duplication and deletion caused by over-replication at a fork barrier

Nature Communications, 2023
Replication fork stalling can provoke fork reversal to form a four-way DNA junction. This remodelling of the replication fork can facilitate repair, aid bypass of DNA lesions, and enable replication restart, but may also pose a risk of over-replication ...
Judith Oehler, Carl A. Morrow, Matthew C. Whitby   +2 more
doaj   +1 more source

The linker histone H1–BRCA1 axis is a crucial mediator of replication fork stability

Life Science Alliance, 2023
The replication-dependent histones H1 interact with BRCA1 upon replication stress. Cells deficient for H1 fail to recruit BRCA1 to stalled replication forks and undergo fork resection and collapse.
Meryem Ozgencil, Arlinda Dullovi, Romane Catherine Christiane Higos, Zuzana Hořejší, Roberto Bellelli   +4 more
doaj   +1 more source

Chl1 helicase controls replication fork progression by regulating dNTP pools

Life Science Alliance, 2022
Chl1 helicase affects RPA-dependent checkpoint activation after replication fork arrest by ensuring proper dNTP levels, thereby controlling replication fork progression under stress conditions.
Amandine Batté, Sophie C van der Horst, Mireille Tittel-Elmer, Su Ming Sun, Sushma Sharma, Jolanda van Leeuwen, Andrei Chabes, Haico van Attikum   +7 more
doaj   +1 more source

PCNA, the Maestro of the Replication Fork [PDF]

Cell, 2007
Inheritance requires genome duplication, reproduction of chromatin and its epigenetic information, mechanisms to ensure genome integrity, and faithful transmission of the information to progeny. Proliferating cell nuclear antigen (PCNA)-a cofactor of DNA polymerases that encircles DNA-orchestrates several of these functions by recruiting crucial ...
Moldovan, G., Pfander, B., Jentsch, S.
openaire   +3 more sources

Replication Fork Reversal and Protection [PDF]

Frontiers in Cell and Developmental Biology, 2021
During genome replication, replication forks often encounter obstacles that impede their progression. Arrested forks are unstable structures that can give rise to collapse and rearrange if they are not properly processed and restarted. Replication fork reversal is a critical protective mechanism in higher eukaryotic cells in response to replication ...
Shan Qiu, Shan Qiu, Shan Qiu, Guixing Jiang, Liping Cao, Jun Huang, Jun Huang   +6 more
openaire   +3 more sources