Results 21 to 30 of about 76,259 (304)
Genome-wide analysis of DNA replication and DNA double-strand breaks using TrAEL-seq.
PLoS Biology, 2021 Faithful replication of the entire genome requires replication forks to copy large contiguous tracts of DNA, and sites of persistent replication fork stalling present a major threat to genome stability.
Neesha Kara +3 more
doaj +1 more source
Homologous Recombination: To Fork and Beyond [PDF]
, 2018 Accurate completion of genome duplication is threatened by multiple factors that hamper the advance and stability of the replication forks. Cells need to tolerate many of these blocking lesions to timely complete DNA replication, postponing their repair ...
Prado Velasco, José Félix
core +1 more source
Eukaryotic DNA Replication Fork [PDF]
Annual Review of Biochemistry, 2017 This review focuses on the biogenesis and composition of the eukaryotic DNA replication fork, with an emphasis on the enzymes that synthesize DNA and repair discontinuities on the lagging strand of the replication fork. Physical and genetic methodologies aimed at understanding these processes are discussed.
Peter M J, Burgers, Thomas A, Kunkel
openaire +2 more sources
Top2 and Sgs1-Top3 Act Redundantly to Ensure rDNA Replication Termination. [PDF]
PLoS Genetics, 2015 Faithful DNA replication with correct termination is essential for genome stability and transmission of genetic information. Here we have investigated the potential roles of Topoisomerase II (Top2) and the RecQ helicase Sgs1 during late stages of ...
Kamilla Mundbjerg +8 more
doaj +1 more source
A requirement for STAG2 in replication fork progression creates a targetable synthetic lethality in cohesin-mutant cancers. [PDF]
, 2019 Cohesin is a multiprotein ring that is responsible for cohesion of sister chromatids and formation of DNA loops to regulate gene expression. Genomic analyses have identified that the cohesin subunit STAG2 is frequently inactivated by mutations in cancer.
Ashworth, Alan +4 more
core +2 more sources
Replisome Dynamics and Their Functional Relevance upon DNA Damage through the PCNA Interactome
Cell Reports, 2018 Summary: Eukaryotic cells use copious measures to ensure accurate duplication of the genome. Various genotoxic agents pose threats to the ongoing replication fork that, if not efficiently dealt with, can result in replication fork collapse. It is unknown
Mrinal Srivastava +6 more
doaj +1 more source
Gaps and forks in DNA replication: Rediscovering old models [PDF]
, 2006 Most current models for replication past damaged lesions envisage that translesion synthesis occurs at the replication fork. However older models suggested that gaps were left opposite lesions to allow the replication fork to proceed, and these gaps were
Alan R. Lehmann +18 more
core +1 more source
Replication dynamics of recombination-dependent replication forks [PDF]
Nature Communications, 2020 Abstract Replication forks restarted by homologous recombination are error prone and replicate both strands semi-conservatively using Pol δ. Here, we use polymerase usage sequencing to visualize in vivo replication dynamics of HR-restarted forks at an S.
Karel Naiman +5 more
openaire +6 more sources
ATPase cycle and DNA unwinding kinetics of RecG helicase [PDF]
, 2012 The superfamily 2 bacterial helicase, RecG, is a monomeric enzyme with a role in DNA repair by reversing stalled replication forks. The helicase must act specifically and rapidly to prevent replication fork collapse. We have shown that RecG binds tightly
Powell, Ben +2 more
core +7 more sources
Rad53 regulates replication fork restart after DNA damage in Saccharomyces cerevisiae [PDF]
, 2008 Replication fork stalling at a DNA lesion generates a damage signal that activates the Rad53 kinase, which plays a vital role in survival by stabilizing stalled replication forks.
Szyjka, S. J. +6 more
core +1 more source