Results 21 to 30 of about 508,345 (256)

Genome-wide analysis of DNA replication and DNA double-strand breaks using TrAEL-seq.

PLoS Biology, 2021
Faithful replication of the entire genome requires replication forks to copy large contiguous tracts of DNA, and sites of persistent replication fork stalling present a major threat to genome stability.
Neesha Kara, Felix Krueger, Peter Rugg-Gunn, Jonathan Houseley   +3 more
doaj   +1 more source

Pathological replication in cells lacking RecG DNA translocase [PDF]

, 2009
This is an open access article, shared under a Creative Commons licence. Copyright © 2009 The Authors.Little is known about what happens when forks meet to complete DNA replication in any organism.
Lloyd, RG, Robert G. Lloyd, Lynda Harris, Harris, L, Christian J. Rudolph, Amy L. Upton, Rudolph, CJ, Upton, AL   +7 more
core   +1 more source

The DNA-binding domain of S. Pombe Mrc1 (Claspin) acts to enhance stalling at replication barriers [PDF]

, 2015
Funding: Marie Curie Cancer Care (J.Z. and J.Z.D.), Biotechnology and Biological Sciences Research Council (J.Z.D.) and Cancer Research UK (E.H.) supported this work.During S-phase replication forks can stall at specific genetic loci.
Dalgaard, J.Z., Emma Louise Godfrey, Zech, Jurgen, Emma Louise Godfrey (774106), Godfrey, E.L., Jacob Zeuthen Dalgaard, Hisao Masai (59105), Edgar Hartsuiker, Zech, J., Juergen Zech (774105), Jacob Zeuthen Dalgaard (774107), Masai, H., Hartsuiker, E., Juergen Zech, Edgar Hartsuiker (254659), Hisao Masai   +15 more
core   +1 more source

Chk1 inhibits replication factory activation but allows dormant origin firing in existing factories [PDF]

, 2010
Replication origins are licensed by loading MCM2-7 hexamers before entry into S phase. However, only similar to 10% of licensed origins are normally used in S phase, with the others remaining dormant.
Blow, J. Julian; id_orcid, Ge, Xin Quan, J. Julian Blow, Xin Quan Ge, Blow, J. Julian   +4 more
core   +1 more source

Inter-Fork Strand Annealing causes genomic deletions during the termination of DNA replication

eLife, 2017
Problems that arise during DNA replication can drive genomic alterations that are instrumental in the development of cancers and many human genetic disorders. Replication fork barriers are a commonly encountered problem, which can cause fork collapse and
Carl A Morrow, Michael O Nguyen, Andrew Fower, Io Nam Wong, Fekret Osman, Claire Bryer, Matthew C Whitby   +6 more
doaj   +1 more source

ruvA Mutants that resolve Holliday junctions but do not reverse replication forks [PDF]

, 2008
RuvAB and RuvABC complexes catalyze branch migration and resolution of Holliday junctions (HJs) respectively. In addition to their action in the last steps of homologous recombination, they process HJs made by replication fork reversal, a reaction which ...
Bradley Alison Sylvia, Tsaneva, I, Tsaneva Irina, Bénédicte Michel, Baharoglu Zeynep, Irina Tsaneva, Zeynep Baharoglu, Marie Le Masson, Michel, B, Bradley, AS, Baharoglu, Z, Le Masson Marie, Michel Bénédicte, Alison Sylvia Bradley, Le Masson, M   +14 more
core   +2 more sources

Molecular Characterization of the Dbf4/Drf1-Dependent Kinase (DDK) and the DNA Replication Checkpoint Mediator Claspin in Xenopus Egg Extracts [PDF]

, 2010
The integrity of DNA replication control and checkpoint mechanisms is essential for preventing tumorigenesis. DNA replication is initiated by the S-CDK and DDK kinases which mediate the unwinding of the replication fork.
Gold, Daniel A.
core   +1 more source

Opposing Roles of FANCJ and HLTF Protect Forks and Restrain Replication during Stress

Cell Reports, 2018
Summary: The DNA helicase FANCJ is mutated in hereditary breast and ovarian cancer and Fanconi anemia (FA). Nevertheless, how loss of FANCJ translates to disease pathogenesis remains unclear.
Min Peng, Ke Cong, Nicholas J. Panzarino, Sumeet Nayak, Jennifer Calvo, Bin Deng, Lihua Julie Zhu, Monika Morocz, Lili Hegedus, Lajos Haracska, Sharon B. Cantor   +10 more
doaj   +1 more source

Dynamics of DNA replication loops reveal temporal control of lagging-strand synthesis [PDF]

, 2009
In all organisms, the protein machinery responsible for the replication of DNA, the replisome, is faced with a directionality problem. The antiparallel nature of duplex DNA permits the leading-strand polymerase to advance in a continuous fashion, but ...
Richardson, Charles C.,, Takahashi, Masateru, Vanoijen, Antoine M., Hamdan, Samir M., Joseph J. Loparo, Loparo, Joseph J., Richardson, Charles C., Takahashi, Masateru,, Oijen, Antoine M. van, Oijen, Antoine M. van,, Loparo, Joseph J.,, Antoine M. van Oijen, Samir M. Hamdan, Masateru Takahashi, Hamdan, Samir M.,, Charles C. Richardson   +15 more
core   +3 more sources

The COMPASS subunit Spp1 protects nascent DNA at the Tus/Ter replication fork barrier by limiting DNA availability to nucleases

Nature Communications, 2023
Homologous recombination factors play a crucial role in protecting nascent DNA during DNA replication, but the role of chromatin in this process is largely unknown.
Nagham Ghaddar, Yves Corda, Pierre Luciano, Martina Galli, Ylli Doksani, Vincent Géli   +5 more
doaj   +1 more source