Results 61 to 70 of about 76,259 (304)

Mitochondrial transcription termination factor 1 directs polar replication fork pausing [PDF]

, 2016
During replication of nuclear ribosomal DNA (rDNA), clashes with the transcription apparatus can cause replication fork collapse and genomic instability.
Falkenberg, Maria, Gustafsson, Claes M., Hyvärinen, Anne K., Jacobs, Howard T., Posse, Viktor, Shi, Yonghong, Zhu, Xuefeng   +6 more
core   +2 more sources

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

ATP Binding to Rad5 Initiates Replication Fork Reversal by Inducing the Unwinding of the Leading Arm and the Formation of the Holliday Junction

Cell Reports, 2018
Summary: Replication fork reversal is one of the major pathways for reactivating stalled DNA replication. Many enzymes with replication fork reversal activity have DNA-unwinding activity as well, but none of the fork reversal enzymes in the SWI/SNF ...
Soochul Shin, Kwangbeom Hyun, Jaehoon Kim, Sungchul Hohng   +3 more
doaj   +1 more source

Human PIF1 helicase supports DNA replication and cell growth under oncogenic-stress [PDF]

, 2014
Unwinding duplex DNA is a critical processing step during replication, repair and transcription. Pif1 are highly conserved non-processive 5′->3′ DNA helicases with well-established roles in maintenance of yeast genome stability.
Bar-Sagi, Bensimon, Blow, Blow, Blow, Brosh, Caldecott, Campbell, Cantor, d'Adda di Fagagna, Diffley, Foiani, Furuichi, Furuichi, German, Gu, Harrington, Helleday, Helleday, Hickson, Hodgson, Holt, Huang, Huang, Ira, Jackson, Kamiya, Kanaar, Kerem, Klein, Lemaitre, Malkova, Meuth, Meuth, Meuth, Mirkin, Mirkin, Monnat, Nicolas, Nicolas, Niedzwiedz, O'Donnell, Petermann, Pichierri, Pombo, Sanders, Sanders, Stambrook, Tijsterman, Tort, Tsunoda, Waga, Whitby, Wilson, Zakian, Zakian, Zakian, Zakian, Zakian, Zakian, Zakian, Zakian, Zakian, Zhou, Zhu   +64 more
core   +3 more sources

Epigenetic blind spots – the role of DNA methylation dynamics in stem cell‐based models of embryogenesis

FEBS Letters, EarlyView.
Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil, Anna Corrà, Annalisa Scapolatiello, Chengxiang Qiu, Gianluca Amadei   +4 more
wiley   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Embryonic stem cells maintain high origin activity and slow forks to coordinate replication with cell cycle progression

EMBO Reports
Embryonic stem (ES) cells are pluripotent stem cells that can produce all cell types of an organism. ES cells proliferate rapidly and are thought to experience high levels of intrinsic replication stress.
Kiminori Kurashima, Yasunao Kamikawa, Tomomi Tsubouchi   +2 more
doaj   +1 more source

Identification of replication fork-associated proteins in Drosophila embryos and cultured cells using iPOND coupled to quantitative mass spectrometry

Scientific Reports, 2022
Replication of the eukaryotic genome requires the formation of thousands of replication forks that must work in concert to accurately replicate the genetic and epigenetic information.
Alexander Munden, Madison T. Wright, Dongsheng Han, Reyhaneh Tirgar, Lars Plate, Jared T. Nordman   +5 more
doaj   +1 more source

Dicer prevents genome instability in response to replication stress [PDF]

, 2019
Dicer, an endoribonuclease best-known for its role in microRNA biogenesis and RNA interference pathway, has been shown to play a role in the DNA damage response and repair of double-stranded DNA breaks (DSBs) in mammalian cells.
Barra, Viviana, Bordignon, Benoit, Coquelle, Arnaud, Egger, Tom, Fragkos, Michalis, Lemacon, Delphine, Naim, Valeria   +6 more
core   +2 more sources

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source