Results 251 to 260 of about 1,971,949 (299)

Origins of DNA replication in eukaryotes

Molecular Cell, 2023
Errors occurring during DNA replication can result in inaccurate replication, incomplete replication, or re-replication, resulting in genome instability that can lead to diseases such as cancer or disorders such as autism. A great deal of progress has been made toward understanding the entire process of DNA replication in eukaryotes, including the ...
Yixin Hu, Bruce Stillman
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The origins of replication of granuloviruses

Archives of Virology, 2008
The genomes of eight granuloviruses (GVs), have been analyzed for the presence of homologous regions (hrs) that may act as origins of replication. Thirteen 74-76-bp palindromes within 11 hrs have previously been identified in the Cydia pomonella GV (CpGV) genome and found to replicate in an infection-dependent DNA replication assay. We report a further
Sally, Hilton, Doreen, Winstanley
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Mammalian origins of replication

BioEssays, 1992
AbstractIt has been almost twenty‐five years since Huberman and Riggs first showed that there are multiple bidirectional origins of replication scattered at ∼100 kb intervals along mammalian chromosomal fibers. Since that time, every conceivable physical property unique to replicating DNA has been taken advantage of to determine whether origins of ...
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Cybernetic origins of replication

Origins of life and evolution of the biosphere, 1988
An evolutionary progression leading toward replication is resolved into several phases; (a) the replication of RNA segments by self-priming and -templating, (b) the replication of single stranded molecules by elongation and controlled scission, (c) replication of complementary duplexes and (d) replication of DNA.
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Unearthing worm replication origins

Nature Structural & Molecular Biology, 2017
Unlike in animals in which gastrulation marks the onset of zygotic transcription and a transition from random to site-specific localization of replication origins, transcription and origin specification in Caenorhabditis elegans are in place before gastrulation.
Takayo, Sasaki, David M, Gilbert
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Multiple origins of replication in archaea

Trends in Microbiology, 2004
Until recently, the only archaeon for which a bona fide origin of replication was reported was Pyrococcus abyssi, where a single origin was identified. Although several in silico analyses have suggested that some archaeal species might contain more than one origin, this has only been demonstrated recently.
Lori M, Kelman, Zvi, Kelman
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The Origin of Adenovirus DNA Replication

1983
Current efforts to understand regulation of replication and cell growth often focus on initiation of DNA replication at an origin sequence. It is most likely, although not yet proven in eukaryotes, that the ultimate step in the regulation of the G to S transition in the cell cycle is the priming of DNA synthesis at an origin.
Tamanoi, F., Stillman, B. W.
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A Replication Origin of Bacillus thuringiensis

Current Microbiology, 2000
A replication origin of Bacillus thuringiensis (Bt) was found in a Bacillus thuringiensis-Escherichia coli shuttle vector of pHT3101. Deletion analysis showed that the replication origin was segregationally stable at suitable temperature for Bt growth. The fragment containing the replication origin was cloned in pUC18 and sequenced.
J, Yu, Y, Zhang, Y, Pang, M, Xu
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Bacterial chromosome origins of replication

Current Opinion in Genetics & Development, 1993
Bacteria regulate chromosomal replication from one specific origin. We compare the regulatory requirements, DNA structures, and biochemical properties of the prototypic Escherichia coli origin with those of evolutionarily distant Bacillus subtilis and Caulobacter crescentus origins.
G T, Marczynski, L, Shapiro
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The regulation of replication origin activation

Current Opinion in Genetics & Development, 1999
At the start of the cell-division programme, proteins must be assembled onto replication origins to establish competence for initiation of DNA synthesis. At the correct moment, other effectors must then coordinate appropriate firing of the various origins to control entry into and progress through S phase.
Donaldson, Anne D., Blow, J. Julian
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