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Origins of replication and gene regulation
Molecular and Cellular Biochemistry, 1984Eukaryotic chromosomes appear to consist of many replicons, the time of replication of which is probably controlled by specific origins. However, plasmids without specific eukaryotic origins may also replicate in some cells when injected into nuclei or transferred during transformation.
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Probing replication origins with a fork
Trends in Cell Biology, 1991In 1968, Huberman and Riggs used DNA-fibre autoradiography to dem- onstrate that the replication of eukaryotic chromosomes occurs bi- directionally from multiple discrete sites that appear to be irregularly spaced along the chromosome t. Since then, the specific sequence requirements of prokaryotic and viral replication origins have been well ...
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The replication origin of Azotobacter vinelandii
Molecular and General Genetics MGG, 2000The putative replication origin of Azotobacter vinelandii was cloned as an autonomously replicating fragment after ligation to an antibiotic resistance cartridge. The resulting plasmids could be isolated and labelled by Southern hybridisation with the antibiotic resistance cartridge as probe and also visualised by electron microscopy.
R A, Singh, N R, Choudhury, H K, Das
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Cancer: Involvement of replicative origins?
Medical Hypotheses, 1986The assumption is made that movable genetic elements related to cancer are replicons and/or replicative origins. Some evidence is provided that certain mobile Alu-origins may represent candidates for precursors of chromosomal insertions. They could incorporate and interact with "fixed" chromosomal origins converting them to "procaryotic" ones. In other
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The Search for Origins of DNA Replication
Methods, 1997The past decade has witnessed an explosion of new information about the nature of DNA replication in eukaryotic cells. Much of this information has resulted from the advent of novel methods for identifying and characterizing origins of DNA replication in the genomes of viruses, plasmids, and cells.
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Eukaryotic replication origins
Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression, 1992P G, Held, N H, Heintz
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Replication | DNA Replication: Eukaryotic Origins and the Origin Recognition Complex
2021Igor Chesnokov, Katarina Akhmetova
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Replication origins in the eucaryotic chromosome
Cell, 1981R A, Laskey, R M, Harland
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