Results 31 to 40 of about 3,588,418 (239)
Creating a novel origin of replication through modulating DNA-protein interfaces. [PDF]
PLoS ONE, 2010 While the molecular mechanisms of DNA-protein specificity at the origin of replication have been determined in many model organisms, these interactions remain unknown in the majority of higher eukaryotes and numerous vertebrate viruses.
F Curtis Hewitt, R Jude Samulski
doaj +1 more source
Identification of a Novel 81-kDa Component of the Xenopus Origin Recognition Complex [PDF]
, 1998 The Xenopus origin recognition complex is essential for chromosomal DNA replication in cell-free extracts. We have immunopurified the Xenopus origin recognition complex with anti-Xorc2 antibodies and analyzed its composition and properties.
Carpenter, Phillip B. +1 more
core +1 more source
Replication control: Choreographing replication origins [PDF]
Current Biology, 1998 Budding yeast replication origins are activated during S phase according to a predetermined temporal programme. Two recent studies indicate that this programme is executed, at least in part, by the S-phase-promoting cyclins that act to assemble a pre-initiation complex which includes the Cdc45 protein.
openaire +2 more sources
Viruses, 2019 The begomoviruses (BGVs) are plant pathogens that evolved in the Old World during the Cretaceous and arrived to the New World (NW) in the Cenozoic era.
Sandra Iliana Torres-Herrera +9 more
doaj +1 more source
Molecules and Cells, 2017 Summary The integrity of eukaryotic genomes requires rapid and regulated chromatin replication. How this is accomplished is still poorly understood. Using purified yeast replication proteins and fully chromatinized templates, we have reconstituted this ...
Christoph F. Kurat +4 more
semanticscholar +1 more source
Evolutionary rates and gene dispensability associate with replication timing in the Archaeon Sulfolobus islandicus [PDF]
, 2010 In bacterial chromosomes, the position of a gene relative to the single origin of replication generally reflects its replication timing, how often it is expressed, and consequently, its rate of evolution.
Cooper, Vaughn S. +3 more
core +2 more sources
Metazoan DNA replication origins [PDF]
Current Opinion in Cell Biology, 2019 DNA replication starts with the opening of DNA at sites called DNA replication origins. From the single sequence-specific DNA replication origin of the small Escherichia coli genome, up to thousands of origins that are necessary to replicate the large human genome, strict sequence specificity has been lost.
Olivier, Ganier +3 more
openaire +2 more sources
Changing Perspectives on the Role of DnaA-ATP in Orisome Function and Timing Regulation
Frontiers in Microbiology, 2019 Bacteria, like all cells, must precisely duplicate their genomes before they divide. Regulation of this critical process focuses on forming a pre-replicative nucleoprotein complex, termed the orisome.
Alan C. Leonard +3 more
doaj +1 more source
Origins of DNA replication in eukaryotes.
Molecules and Cells, 2023 Errors occurring during DNA replication can result in inaccurate replication, incomplete replication, or re-replication, resulting in genome instability that can lead to diseases such as cancer or disorders such as autism.
Yixin Hu, B. Stillman
semanticscholar +1 more source
Genome-wide mapping reveals single-origin chromosome replication in Leishmania, a eukaryotic microbe [PDF]
, 2015 Background DNA replication initiates on defined genome sites, termed origins. Origin usage appears to follow common rules in the eukaryotic organisms examined to date: all chromosomes are replicated from multiple origins, which display variations in ...
Campbell, Samantha J. +4 more
core +2 more sources