Results 51 to 60 of about 3,588,418 (239)

Mutant p53 establishes targetable tumor dependency by promoting unscheduled replication [PDF]

, 2017
Gain-of-function (GOF) p53 mutations are observed frequently in most intractable human cancers and establish dependency for tumor maintenance and progression.
Beckerman, Bronte, Catherine A. Vaughan, Frum, Lin, Luzhna, Olivier, Oren, Rebecca A. Frum, Shilpa Singh, Steven R. Grossman, Sumitra Deb, Swati Palit Deb, Zeman, Zuazua-Villar   +14 more
core   +2 more sources

The Macromolecular Machines that Duplicate the Escherichia coli Chromosome as Targets for Drug Discovery

Antibiotics, 2018
DNA replication is an essential process. Although the fundamental strategies to duplicate chromosomes are similar in all free-living organisms, the enzymes of the three domains of life that perform similar functions in DNA replication differ in amino ...
Jon M. Kaguni
doaj   +1 more source

Dynamic relocalization of replication origins by Fkh1 requires execution of DDK function and Cdc45 loading at origins

eLife, 2019
Chromosomal DNA elements are organized into spatial domains within the eukaryotic nucleus. Sites undergoing DNA replication, high-level transcription, and repair of double-strand breaks coalesce into foci, although the significance and mechanisms giving ...
Haiyang Zhang, Meghan V Petrie, Yiwei He, Jared M Peace, Irene E Chiolo, Oscar M Aparicio   +5 more
doaj   +1 more source

The bacterial DnaA-trio replication origin element specifies ssDNA initiator binding

Nature, 2016
The bacterial chromosome replication origin contains an indispensable element composed of a repeating trinucleotide motif, termed the DnaA-trio, that stabilizes DnaA binding on single-stranded DNA.
Tomas T Richardson, Omar Harran, H. Murray   +2 more
semanticscholar   +1 more source

Escalation of error catastrophe for enzymatic self-replicators [PDF]

, 2007
It is a long-standing question in origin-of-life research whether the information content of replicating molecules can be maintained in the presence of replication errors.
B. Obermayer, E. Frey, Jain K. Krug J., Schuster P., Stadler P., Tee G.   +5 more
core   +2 more sources

DNA replication: archaeal oriGINS [PDF]

BMC Biology, 2011
GINS is an essential eukaryotic DNA replication factor that is found in a simplified form in Archaea. A new study in this issue of BMC Biology reveals the first structure of the archaeal GINS complex. The structure reveals the anticipated similarity to the previously determined eukaryotic complex but also has some intriguing differences in the relative
openaire   +4 more sources

Regulation of Replication Origins [PDF]

, 2017
In eukaryotes, genome duplication starts concomitantly at many replication initiation sites termed replication origins. The replication initiation program is spatially and temporally coordinated to ensure accurate, efficient DNA synthesis that duplicates the entire genome while maintaining other chromatin-dependent functions. Unlike in prokaryotes, not
Anna B, Marks, Haiqing, Fu, Mirit I, Aladjem   +2 more
openaire   +2 more sources

An ATR and CHK1 kinase signaling mechanism that limits origin firing during unperturbed DNA replication

Proceedings of the National Academy of Sciences of the United States of America, 2019
Significance The 50,000 origins that replicate the human genome are selected from an excess of licensed origins. Firing licensed origins that would otherwise be passively replicated is a simple mechanism to recover DNA replication between stalled ...
T. Moiseeva, Yandong Yin, Michael J. Calderon, Chenao Qian, Sandy Schamus-Haynes, Norie Sugitani, Hatice U. Osmanbeyoglu, E. Rothenberg, Simon C Watkins, C. Bakkenist   +9 more
semanticscholar   +1 more source

Influence of retinoblastoma-related gene silencing on the initiation of DNA replication by African cassava mosaic virus Rep in cells of mature leaves in Nicotiana benthamiana plants [PDF]

, 2011
Background Geminiviruses mainly infect terminally differentiated tissues and cells in plants. They need to reprogramme host cellular machinery for DNA replication.
Bruce, Gareth, Gu, Mei, Shi, Nongnong, Liu, Yule, Hong, Yiguo   +4 more
core   +2 more sources

Ori-Finder 2022: A Comprehensive Web Server for Prediction and Analysis of Bacterial Replication Origins

Genomics, Proteomics & Bioinformatics, 2022
The replication of DNA is a complex biological process that is essential for life. Bacterial DNA replication is initiated at genomic loci referred to as replication origins (oriCs).
Mei-Jing Dong, Hao Luo, Feng Gao
doaj   +1 more source