Results 191 to 200 of about 817,676 (313)

Competition for DNA binding between the genome protector replication protein A and the genome modifying APOBEC3 single-stranded DNA deaminases. [PDF]

Nucleic Acids Res, 2022
Wong L, Sami A, Chelico L.
europepmc   +1 more source

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

Molecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang, Hyung Seok Kim, Geum Ok Baek, Moon Gyeong Yoon, Su In Lee, Jee‐Yeong Jeong, Ji Eun Han, Soon Sun Kim, Jae Youn Cheong, Jung Woo Eun   +9 more
wiley   +1 more source

A genome-wide genetic screen identifies a novel kDNA replication protein in trypanosomes. [PDF]

Nucleic Acids Res
Miskinyte M, Jetishi C, Kalichava A, Ivens A, Waterfall M, Gould MK, Glover L, Horn D, Ochsenreiter T, Schnaufer A.   +9 more
europepmc   +1 more source

High-Resolution Structure of the Nuclease Domain of the Human Parvovirus B19 Main Replication Protein NS1. [PDF]

J Virol, 2022
Sanchez JL, Ghadirian N, Horton NC.
europepmc   +1 more source

Translating whole‐genome doubling into precision medicine in cancer

Molecular Oncology, EarlyView.
Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley   +1 more source

Clinicopathological and functional evaluation of replication protein A in epithelial ovarian cancers: A target validation study. [PDF]

Transl Oncol
Algethami M, Sheha A, Singhania N, Alqahtani S, Shoqafi A, Tosun Ç, Spicer J, Toss MS, Alblihy A, Lashen A, Jeyapalan JN, Mongan NP, Rakha EA, Madhusudan S.   +13 more
europepmc   +1 more source

Replication Protein A Enhances Kinetics of Uracil DNA Glycosylase on ssDNA and Across DNA Junctions: Explored with a DNA Repair Complex Produced with SpyCatcher/SpyTag Ligation. [PDF]

Chembiochem, 2023
Greenwood SN, Kulkarni RS, Mikhail M, Weiser BP.   +3 more
europepmc   +1 more source

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

Characterization of antibodies against the replication protein (Rep) encoded by bovine meat and milk factors (BMMFs). [PDF]

Appl Microbiol Biotechnol
Frehtman V, Shukla G, Gentz M, Müller M, Duduyemi OP, Grewe I, Ernst C, Tessmer C, Didier A, Hofmann I, Bund T, Leuchs B.   +11 more
europepmc   +1 more source

The DNA replication protein Orc1 from the yeast Torulaspora delbrueckii is required for heterochromatin formation but not as a silencer-binding protein. [PDF]

Genetics, 2022
Maria H, Rusche LN.
europepmc   +1 more source