Results 271 to 280 of about 1,154,263 (301)

DNA unwinding activity of replication protein A [PDF]

FEBS Letters, 1992
Replication protein A (RP‐A) is a heterotrimeric complex conserved in cukaryotic cells. It binds to single‐stranded DNA and is essential for initiation and elongation of DNA replication. In this communication we give evidence that this protein can unwind DNA independent of magnesium and ATP, two essential cofactors for bona fide DNA helicase activity ...
U Hubscher, U Hubscher
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Replication Protein A as a Potential Regulator of DNA Replication in Cells Exposed to Hyperthermia

Radiation Research, 1998
It is well known that exposure of cells to heat leads to a drastic inhibition of DNA synthesis as assayed in vivo by the incorporation of radioactive precursors into acid-insoluble material. Here we introduce an SV40 in vitro DNA replication assay and show that this inhibition may be partly due to the activation of a checkpoint in S phase that stalls ...
Y, Wang, A R, Perrault, G, Iliakis
openaire   +2 more sources

Flanders virus replication and protein synthesis

Virology, 1988
The prototype strain of Flanders virus (61-7484) has been adapted to grow in Vero cell cultures and a plaque assay has been developed. Electron micrographs of infected cells revealed rod-shaped virions budding in clusters from the plasma membrane, consistent with the tentative classification of Flanders virus as a member of the Rhabdoviridae.
K R, Boyd, P, Whitaker-Dowling
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DNA Replication Fork Proteins

2009
DNA replication is a complex mechanism that functions due to the co-ordinated interplay of several dozen protein factors. In the last few years, numerous studies suggested a tight implication of DNA replication factors in several DNA transaction events that maintain the integrity of the genome.
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Multiple Roles of Viral Replication Proteins in Plant RNA Virus Replication

2008
Identification of the roles of replication factors represents one of the major frontiers in current virus research. Among plant viruses, the positive-stranded (+) RNA viruses are the largest group and the most widespread. The central step in the infection cycles of (+) RNA viruses is RNA replication, which leads to rapid production of huge number of ...
Peter D, Nagy, Judit, Pogany
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Host Proteins in the Replication of Bacteriophage RNA

1973
In recent years, the bacteriophage Qβ RNA polymerase reaction has become a highly characterized system for studying the synthesis of genetic material. An outstanding feature of this reaction is the actual replication of infectious bacteriophage RNA, as first shown by Spiegelman et al. (1).
J T, August, L, Eoyang, M T, Franze de Fernández, W S, Hayward, C H, Kuo, P M, Silverman   +5 more
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Coronavirus Replicative Proteins

2014
Over the past few years, impressive progress into the functions and structures of coronavirus replicative proteins has been made. Nevertheless, our understanding of the molecular mechanisms that coronaviruses have evolved to synthesize, express, and maintain their unusually large RNA genomes is still far from being complete.
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Eukaryotic replicators and associated protein complexes

Current Opinion in Genetics & Development, 1995
In the past year, genetic studies have provided a detailed understanding of the DNA sequence elements that constitute Saccharomyces cerevisiae origins of DNA replication and have identified larger DNA domains that direct DNA replication in both Schizosaccharomyces pombe and human cells. In vivo studies of the proteins associated with S.
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DNA Replication Proteins of Escherichia Coli

Annual Review of Biochemistry, 1978
PERSPECTIVES AND SUMMARY ..... .. .. 1163 ESCHERICHIA COLI CHROMOSOME REPLICATION ........ .. ..... ...... .... 116S In Vivo DNA Replication 1165 In Vitro DNA Replication 1166 SINGLE-STRANDED CIRCULAR DNA-DEPENDENT DNA SYNTHESIS .... 1168 Priming of Single-Stranded DNA Synthesis ..
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Replication of hepatitis A virus and processing of proteins

Vaccine, 1992
Isolation and propagation of hepatitis A virus (HAV) in cell culture is routinely possible. All primary HAV isolates and most established virus strains, however, show a protracted replication behaviour and tend to establish a persistent infection. Rapidly replicating, cytolytic variant viruses can be selected from persistently infected cultures under ...
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