Results 281 to 290 of about 817,676 (313)

Interplay of replication checkpoints and repair proteins at stalled replication forks

DNA Repair, 2007
DNA replication is an essential process that occurs in all growing cells and needs to be tightly regulated in order to preserve genetic integrity. Eukaryotic cells have developed multiple mechanisms to ensure the fidelity of replication and to coordinate the progression of replication forks.
D. Branzei, M. Foiani
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Adenovirus DNA Replication: Mechanism and Replication Proteins

1983
The human adenoviruses, especially type 5 (Ad5) and type 2 (Ad2), can be easily cultivated in HeLa or KB cells. They have been a favorite subject for DNA replication studies in the eukaryotic cell during the last decade. The mature adenovirus genome isolated from virions consists of a linear duplex DNA molecule of about 35,000 base pairs.
Peter C. van der Vliet, Marijke M. Kwant, Bram G. M. van Bergen, Wim van Driel   +3 more
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MCM Proteins in DNA Replication

Annual Review of Biochemistry, 1999
▪ Abstract  The MCM proteins are essential replication initiation factors originally identified as proteins required for minichromosome maintenance in Saccharomyces cerevisiae. The best known among them are a family of six structurally related proteins, MCM2–7, which are evolutionally conserved in all eukaryotes.
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Replication Protein A as a Potential Regulator of DNA Replication in Cells Exposed to Hyperthermia

Radiation Research, 1998
It is well known that exposure of cells to heat leads to a drastic inhibition of DNA synthesis as assayed in vivo by the incorporation of radioactive precursors into acid-insoluble material. Here we introduce an SV40 in vitro DNA replication assay and show that this inhibition may be partly due to the activation of a checkpoint in S phase that stalls ...
Y, Wang, A R, Perrault, G, Iliakis
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DNA Replication Fork Proteins

2009
DNA replication is a complex mechanism that functions due to the co-ordinated interplay of several dozen protein factors. In the last few years, numerous studies suggested a tight implication of DNA replication factors in several DNA transaction events that maintain the integrity of the genome.
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Multiple Roles of Viral Replication Proteins in Plant RNA Virus Replication

2008
Identification of the roles of replication factors represents one of the major frontiers in current virus research. Among plant viruses, the positive-stranded (+) RNA viruses are the largest group and the most widespread. The central step in the infection cycles of (+) RNA viruses is RNA replication, which leads to rapid production of huge number of ...
Peter D, Nagy, Judit, Pogany
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Flanders virus replication and protein synthesis

Virology, 1988
The prototype strain of Flanders virus (61-7484) has been adapted to grow in Vero cell cultures and a plaque assay has been developed. Electron micrographs of infected cells revealed rod-shaped virions budding in clusters from the plasma membrane, consistent with the tentative classification of Flanders virus as a member of the Rhabdoviridae.
K R, Boyd, P, Whitaker-Dowling
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Protein inheritance: λ plasmid replication perpetuated by the heritable replication complex

Genes to Cells, 1996
Background: Replication of a plasmid derived from the Escherichia coli phage λ initiates by binding of the λO protein initiator to the origin of λ DNA replication, oriλ. The λP protein participates in subsequent steps of assembly of the λ replication complex.
Alicja Węgrzyn, Grzegorz Węgrzyn, Anna Herman, Karol Taylor   +3 more
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Host Proteins in the Replication of Bacteriophage RNA

1973
In recent years, the bacteriophage Qβ RNA polymerase reaction has become a highly characterized system for studying the synthesis of genetic material. An outstanding feature of this reaction is the actual replication of infectious bacteriophage RNA, as first shown by Spiegelman et al. (1).
J T, August, L, Eoyang, M T, Franze de Fernández, W S, Hayward, C H, Kuo, P M, Silverman   +5 more
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Coronavirus Replicative Proteins

2014
Over the past few years, impressive progress into the functions and structures of coronavirus replicative proteins has been made. Nevertheless, our understanding of the molecular mechanisms that coronaviruses have evolved to synthesize, express, and maintain their unusually large RNA genomes is still far from being complete.
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